A5052206633- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Bone Tissue Engineering Materials
- Liver Disease Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Plant Stress Responses and Tolerance
- Healthcare Systems and Reforms
- Cancer Mechanisms and Therapy
- Birth, Development, and Health
- Chemical synthesis and alkaloids
- Wound Healing and Treatments
- Cocoa and Sweet Potato Agronomy
- Diabetes Management and Education
- Seed Germination and Physiology
- Healthcare Systems and Public Health
- Child Nutrition and Water Access
- Air Quality and Health Impacts
- Diabetes Treatment and Management
- 14-3-3 protein interactions
Chongqing Public Health Medical Center
2024
Chongqing Medical University
2024
Henan Provincial People's Hospital
2022-2024
Zhengzhou University
2022-2024
Chongqing Three Gorges Academy of Agricultural Sciences
2024
Anhui Medical University
2023-2024
Chengdu Medical College
2024
Chongqing University
2023
Chengdu University of Traditional Chinese Medicine
2020-2023
Central South University
2022
Hepatocellular carcinoma (HCC) is the predominant subtype of primary liver cancer and represents a highly heterogeneous disease, making it hard to predict prognosis therapy efficacy. Here, we established novel tumor immunological phenotype-related gene index (TIPRGPI) consisting 11 genes by Univariate Cox regression least absolute shrinkage selection operator (LASSO) algorithm HCC immunotherapy response. TIPRGPI was validated in multiple datasets exhibited outstanding performance predicting...
Conventional wound dressings cannot provide an appropriate environment for tissue repair and regeneration easily adhere to wounds causing damage the new epithelial tissues, which leads bleeding. Herein, a antifouling hydrogel based on natural polysaccharide was developed healing. The biocompatible with ideal three-dimensional network composited of chitosan dextran synthesized by Michael addition reaction. showed good swelling cytocompatibility against NIH3T3. Moreover, obtained adjusting...
Hepatocellular carcinoma (HCC) is a common malignant cancer with poor survival outcomes, and hepatitis B virus (HBV) infection most likely to contribute HCC. But the molecular mechanism remains obscure. Our study intended identify candidate potential hub genes associated carcinogenesis of HBV-related HCC (HBV-HCC), which may be helpful in developing novel tumor biomarkers for targeted therapies. Four transcriptome datasets (GSE84402, GSE25097, GSE94660, GSE121248) were used screen 309...
Background: Endometrial cancer (EC) is one of the most lethal gynecological cancers around world. The aim this study to identify potential immune microenvironment-related biomarkers associated with prognosis for EC. Methods: RNA-seq data and clinical information EC patients were derived from Cancer Genome Atlas (TCGA). score each sample was obtained by ESTIMATE algorithm. Weighted gene co-expression network analysis (WGCNA) used interesting module key genes concerning score. expression...
Premature ovarian failure (POF) is defined as amenorrhea that occurs before the age of 40 when ovaries weaken or even fail. This disease seriously affects a woman's future health and fertility. Potential targets Yijing Decoction (YJD) POF were predicted by web-based pharmacology-related databases. The rat models human granulosa cells injury induced triptolide. In addition, estrous cycle rats was monitored vaginal smear tissue morphology stained HE staining. Immunohistochemistry, qRT-PCR...
Hepatocellular carcinoma (HCC), accounting for ~90% of all primary liver cancer, is a prevalent malignancy worldwide. The intratumor heterogeneity its causative etiology, histology, molecular landscape, and immune phenotype makes it difficult to precisely recognize individuals with high mortality risk or tumor-intrinsic treatment resistance, especially immunotherapy. Herein, we comprehensively evaluated the activities cancer hallmark gene sets their correlations prognosis HCC patients using...
Background: Hepatocellular carcinoma (HCC) is a prevalent malignancy with high mortality rate. Cellular senescence, an irreversible state of cell cycle arrest, plays paradoxical role in cancer progression. Here, we aimed to identify subtypes by cellular senescence-related genes (CSGs) and construct gene subtype predictor as well novel prognostic scoring system, which was expected predict clinical outcomes therapeutic response carcinoma. Methods: RNA-seq data information patients were derived...
Wetlands play an important role in the feeding, breeding, and lives of birds. However, available habitats for bird species are changing due to intensifying human activity, especially context China’s mass urbanization. Urban sprawl has taken over wetlands along lakes past decades, which places tremendous pressure on wetland ecosystems and, therefore, communities. ways urban land cover pattern urban-rural gradient affects communities is still unclear. To investigate influence α β diversity...
Hepatitis C virus-associated HCC (HCV-HCC) is a prevalent malignancy worldwide and the molecular mechanisms are still elusive. Here, we screened 240 differentially expressed genes (DEGs) of HCV-HCC from Gene expression omnibus (GEO) Cancer Genome Atlas (TCGA), followed by weighted gene coexpression network analysis (WGCNA) to identify most significant module correlated with overall survival. 10 hub (CCNB1, AURKA, TOP2A, NEK2, CENPF, NUF2, CDKN3, PRC1, ASPM, RACGAP1) were identified four...
Various long-lived mRNAs are stored in seeds, some of which required for the initial phase germination and critical to seed longevity. However, seed-specific involved longevity remain poorly understood rice. To identify these we first performed aging experiment with 14 rice varieties, categorized them as higher (HL) lower (LL) varieties conventional hybrid rice, respectively. Second, RNA-seq analysis showed that most genes similar tendency expression changes during natural artificial aging,...
OBJECTIVE With this study, we aimed to estimate the disease burden attributable child and maternal malnutrition (CMM) throughout world between 1990 2019. METHODS The number, age-standardized rate, population fraction of deaths, disability-adjusted life-years, years life lost, lived with disability associated CMM were estimated using Global Burden Disease Study 2019 by age, sex, year, location, sociodemographic index at global level. slope inequality concentration employed measure...
This study aimed to decipher the bioactive compounds and potential mechanism of traditional Chinese medicine (TCM) formula Fuzi Lizhong Decoction (FLD) for nonalcoholic fatty liver disease (NAFLD) treatment via an integrative network pharmacology approach.The candidate FLD its relative targets were obtained from TCMSP PharmMapper web server, intersection genes NAFLD discerned using OMIM, GeneCards, DisGeNET. Then, PPI component-target-pathway networks constructed. Moreover, GO enrichment...
The high risk of postoperative mortality in lung adenocarcinoma (LUAD) patients is principally driven by cancer recurrence and low response rates to adjuvant treatment. Here, A combined cohort containing 1,026 stage I-III was divided into the learning (n = 678) validation datasets 348). former used establish a 16-mRNA signature for prediction with multiple statistical algorithms, which verified set. Univariate multivariate analyses confirmed it as an independent indicator both...
Abstract Background: Multiple studies have assessed the role of Cassiae semen (CS) in regulating lipid metabolism. However, mechanism action CS on non-alcoholic fatty liver disease (NAFLD) has seen rare scrutiny. Objective: The objective this study was to explore regulatory metabolism NAFLD. Methods: Components ethanol extract (CSEE) were analyzed and identified using UPLC-Q-Orbirap HRMS. candidate compounds its relative targets extracted from Traditional Chinese Medicine Systems...
Ulcerative Colitis (UC) is a major form of chronic inflammatory bowel disease the colonic mucosa and exhibits progressive morbidity. There still substantial need small molecules with greater efficacy safety for UC treatment. Here, we report N-acetyldopamine dimer (NADD) elucidated (2R,3S)-2-(3′,4′-dihydroxyphenyl)-3-acetylamino-7-(N-acetyl-2″-aminoethyl)-1,4-benzodioxane, which derived from traditional Chinese medicine Isaria cicadae , significant therapeutic against dextran sulfate sodium...
Objective: To identify circadian clock (CC)-related key genes with clinical significance, providing potential biomarkers and novel insights into the CC of ovarian cancer (OC). Methods: Based on RNA-seq profiles OC patients in The Cancer Genome Atlas (TCGA), we explored dysregulation prognostic power 12 reported CC-related (CCGs), which were used to generate a index (CCI). Weighted gene co-expression network analysis (WGCNA) protein-protein interaction (PPI) hub genes. Downstream analyses...
This study reviews the research status of Diagnosis-related groups (DRGs) payment system in China and globally by analyzing topical issues this field exploring evolutionary trends DRGs different developmental stages.