A5101872576- Cholesterol and Lipid Metabolism
- Wheat and Barley Genetics and Pathology
- Steroid Chemistry and Biochemistry
- Chemical Synthesis and Analysis
- Estrogen and related hormone effects
- Click Chemistry and Applications
- Peroxisome Proliferator-Activated Receptors
- Sphingolipid Metabolism and Signaling
- Cyclopropane Reaction Mechanisms
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Computational Drug Discovery Methods
- Plant Disease Resistance and Genetics
- Ferroptosis and cancer prognosis
- Cannabis and Cannabinoid Research
- Alcohol Consumption and Health Effects
- Lanthanide and Transition Metal Complexes
- Lysosomal Storage Disorders Research
- Genetic Mapping and Diversity in Plants and Animals
- Drug Transport and Resistance Mechanisms
- Protein Degradation and Inhibitors
- Bacterial biofilms and quorum sensing
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Cancer-related Molecular Pathways
Jinan University
2017-2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2024
Chengdu University of Traditional Chinese Medicine
2022-2024
Nanjing University of Aeronautics and Astronautics
2024
First Affiliated Hospital of Jinan University
2023
Chongqing Academy of Chinese Materia Medica
2010-2022
Avanti Polar Lipids (United States)
2007-2018
Auburn University
1995-2017
Sichuan Mianyang 404 Hospital
2015
Anyang Academy of Agricultural Sciences
2010-2014
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss of midbrain dopaminergic neurons in association with aggregation α-synuclein. Oxidative damage has been widely implicated this disease, though mechanisms involved remain elusive. Here, we demonstrated that preferential accumulation peroxidized phospholipids and antioxidant enzyme glutathione peroxidase 4 (GPX4) were responsible for vulnerability progressive motor dysfunctions mouse model PD. We also...
Abstract Covalent probes coupled with chemical proteomics represent a powerful method for investigating small molecule and protein interactions. However, the creation of reactive warhead within various ligands to form covalent has been major obstacle. Herein, we report convenient robust process assemble unique electrophile, an α- acyloxyenamide, through one-step late-stage coupling reaction. This procedure demonstrates remarkable tolerance towards other functional groups facilitates...
Endocannabinoids (ECs) and cannabinoids are very lipophilic molecules requiring the presence of cytosolic binding proteins that chaperone these to intracellular targets. While three different fatty acid (FABP3, -5, -7) serve this function in brain, relatively little is known about how such hydrophobic ECs transported within liver. The most prominent hepatic FABP, liver protein (FABP1 or L-FABP), has high affinity for arachidonic (ARA) ARA-CoA, suggesting FABP1 may also bind ARA-derived (AEA...
While profiling the lipidome of mouse brain by mass spectrometry, we discovered a novel family N-acylphosphatidylserine (N-acyl-PS) molecules. These N-acyl-PS species were enriched DEAE-cellulose column chromatography, and they then characterized accurate measurements, tandem liquid chromatography/mass comparison to an authentic standard. Mouse molecules are heterogeneous constitute about 0.1% total lipid. In addition various ester-linked fatty acyl chains on their glycerol backbones,...
Covalent inhibitors with an electrophilic warhead have received considerable attention due to their remarkable pharmacological properties. However, the in covalent drugs is often α, β-unsaturated amide, and targets are mainly cysteine or lysine residues. Thus, development of novel electrophiles that can target other amino acids highly desirable. Ynamide, a useful versatile building block, commonly employed construction various compounds organic synthesis. The performance this functional...
Dynamic brain network has the advantage over static in characterizing variation pattern of functional connectivity, and it attracted increasing attention disease diagnosis. However, most existing dynamic networks analysis methods rely on extracting features from independent divided by sliding windows, making them hard to reveal high-order evolution laws networks. Additionally, they cannot effectively extract spatio-temporal topology In this paper, we propose use optimal transport (OT) theory...
Abstract Altered expression of Urea Cycle (UC) enzymes occurs in many tumors, resulting a metabolic hallmark termed as UC dysregulation. Polyamines are synthesized from ornithine, and polyamine synthetic genes elevated various tumors. However, the underlying deregulations UC/ synthesis cancer remain elusive. Here, we characterized hypoxia-induced lncRNA LVBU (lncRNA regulation via BCL6/urea cycle) that is highly expressed colorectal (CRC) correlates with poor prognosis. Increased promoted...
Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) is a powerful method for the study protein structure and protein-protein interactions (PPIs). However, chemical probes used in CXMS are limited to bidentate reactive warheads, available zero-length cross-linkers restricted 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM). To alleviate this...
Abstract Colorectal cancer (CRC) is among the most prevalent and deadly cancers worldwide. The Yes‐associated protein 1 (YAP1) frequently dysregulated in cancers, contributing to stemness, chemoresistance, cancer‐related death. However, strategies directly targeting YAP1 have not yet been successful because of lack active binding pockets unregulated toxicity. In this study, our Food Drug Administration (FDA)‐approved drug screening reveals that abemaciclib, a cyclin‐dependent kinase 4/6...
TRIB3, a pseudokinase, was previously studied within only some specific cancer types, leaving its comprehensive functions in pan-cancer contexts largely unexplored. Here, we performed an integrated analysis of
Activating mutations in NRAS account for 15–20% of melanoma, yet effective anti-NRAS therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator oncogenic mutations, specifically Q61R and Q61K, which most prevalent melanoma. The genetic ablation or pharmacological inhibition CK1δ markedly destabilizes mutants suppresses their functions. Moreover, identify USP46 a bona fide deubiquitinase mutants. Mechanistically, directly phosphorylates...