A5006770551- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Histiocytic Disorders and Treatments
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Mesenchymal stem cell research
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Erythrocyte Function and Pathophysiology
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Vascular Malformations and Hemangiomas
- 3D Printing in Biomedical Research
- Chronic Lymphocytic Leukemia Research
- Tumors and Oncological Cases
- Neutropenia and Cancer Infections
- Neonatal Health and Biochemistry
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Blood properties and coagulation
- Advanced Biosensing Techniques and Applications
- Viral-associated cancers and disorders
- Cell Image Analysis Techniques
- Glioma Diagnosis and Treatment
Ajou University
2014-2024
Korea University Medical Center
2023-2024
Korea University
2011-2023
Ajou University Hospital
2006-2022
Baylor College of Medicine
2018
Pediatric Nephrology of Alabama
2017
Center for Drug Evaluation and Research
2016
United States Food and Drug Administration
2016
Amorepacific (South Korea)
2014-2015
Kangwon National University
2014-2015
The characterization sections of biologics license applications (BLAs) approved by the United States Food and Drug Administration (FDA) between 2000 2015 were investigated to examine extent use mass spectrometry. Mass spectrometry was found be integral these biotherapeutics. Of 80 electronically submitted monoclonal antibody protein biotherapeutic BLAs included in this study, 79 spectrometric workflows for or impurity characterization. To further how MS is being used successful BLAs,...
The clinical practice of oncology is being transformed by molecular diagnostics that will enable predictive and personalized medicine. Current technologies for quantitation the cancer proteome are either qualitative (e.g., immunohistochemistry) or require large sample sizes flow cytometry). Here, we report a microfluidic platform-microfluidic image cytometry (MIC)-capable quantitative, single-cell proteomic analysis multiple signaling molecules using only 1,000 to 2,800 cells. Using cultured...
A nationwide survey was conducted to clarify the clinical features and outcomes of Korean children with Langerhans cell histiocytosis (LCH). Korea Histiocytosis Working Party analyzed data 603 patients who were diagnosed LCH between 1986 2010 from 28 institutions in Korea. Median age at diagnosis 65 months (range, 0 276 mo). Bone most frequently affected organ (79.6%) followed by skin (19.2%). Initially, 419 (69.5%) had single-system involvement (SS), 85 (14.1%) multisystem (MS) disease...
Pre-engraftment syndrome (PES) is poorly characterized, and its clinical significance the prognostic impact after unrelated cord blood transplantation (CBT) are unclear. To address these issues, we retrospectively analyzed incidence, risk factors, outcomes of PES in CBT recipients. Data 381 patients who received from 18 medical centers Korea were reviewed. was defined as unexplained fever >38.3°C not associated with infection, and/or skin rash or without evidence fluid retention before...
Licorice is a traditional botanical medicine, and has historically been commonly prescribed in Asia to treat various diseases. Glycyrrhizin (Gc), triterpene compound, the most abundant phytochemical constituent of licorice. However, high intake or long-term consumption Gc associated with number side effects, including hypertension. presence alternative bioactive compounds licorice anti-carcinogenic effects long suspected. Licochalcone A (LicoA) prominent member chalcone family can be...
Purpose The objective of this study was to explore the relationship between circulating lymphocyte level during preoperative chemoradiotherapy (CRT) and pathologic complete response (pCR) in locally advanced rectal cancer. Materials Methods From May 2010 2013, 52 patients treated with CRT followed by surgery, were analysed. Patients received conventional fractionated radiotherapy (50-54 Gy) fluorouracil-based chemotherapy. Surgical resection performed at 4 8 weeks after completion CRT....
There has been vigorous debate on how different countries responded to the COVID-19 pandemic. To secure public safety, South Korea actively used personal information at risk of privacy whereas France encouraged voluntary cooperation safety. In this article, after a brief comparison contextual differences with France, we focus Korea's approaches epidemiological investigations. evaluate issues pertaining and health, examine usage patterns original data, de-identification encrypted data. Our...
Oxidative stress induced by reactive oxygen species (ROS) is the major cause of degenerative disorders including aging and disease. In this study, we investigated whether Cordyceps militaris extract (CME) has in vitro protective effects on hydrogen peroxide-induced oxidative human dermal fibroblasts (HDFs). Our results showed that 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity CME was increased a dose-dependent manner. We found peroxide treatment HDFs ROS generation cell...
Current diagnostic tests for hereditary spherocytosis (HS) focus on the detection of hemolysis or indirectly assessing defects membrane protein, whereas direct methods to detect protein are complicated and difficult implement. In present study, we investigated patterns genetic variation associated with HS among patients clinically diagnosed HS. Multi-gene targeted sequencing 43 genes (17 RBC protein-encoding genes, 20 enzyme-encoding six additional differential diagnosis) was performed using...
Antithymocyte globulin (ATG) has been used in severe aplastic anemia (SAA) as part of the conditioning regimen. Among many kinds ATG preparations, thymoglobulin had found to be more effective for preventing graft-versus-host disease (GVHD) and rejection organ transplants. After promising results our preliminary study, we conducted a phase II prospective multicenter clinical trial using fludarabine (Flu), cyclophosphamide (Cy), regimen allow good engraftment patients who underwent unrelated...
Purpose Aplastic anemia (AA) is a rare hematologic disease characterized by pancytopenia and hypocellular marrow. The Korean Society of Pediatric Hematology Oncology investigated retrospectively the incidence, survival, transfusion independency according to treatment strategies in AA. Methods All questionnaires were sent members for medical records. We collected analyzed 702 available data. Results male female ratio was 1.2, median age at diagnosis 9.3 years. annual incidence children with...
Soy isoflavone is an attractive source of functional cosmetic materials with anti-wrinkle, whitening and skin hydration effects. After consumption, the majority soy isoflavones are converted to their metabolites in human gastrointestinal tract. To understand physiological impact on body, it necessary evaluate address biological function its metabolites. In this study, we investigated effect 6,7,4'-trihydroxyisoflavone (6,7,4'-THIF), a major metabolite daidzein, against solar UV (sUV)-induced...
We report the outcome of 236 pediatric umbilical cord blood transplantations (UCBT) performed in Korea. Given that sources grafts were mostly unrelated donors (n = 226; 95.8%), only results UCBT included for all statistics. The most frequent primary disease was acute leukemia 167). In total, 91.7% recipients seropositive cytomegalovirus (CMV). median doses nucleated cells and CD34+ 4.84 × 10(7)/kg 2.00 10(5)/kg, respectively. times to neutrophil (>0.5 10(9)/L) platelet recovery (>20 18 45...
It is well known that Phellinus linteus, which produces hispidin and its derivatives, possesses antioxidant activities. In this study, we investigated whether has protective effects on palmitate-induced oxidative stress in C2C12 skeletal muscle cells. Our results showed palmitate treatment myotubes increased ROS generation cell death as compared with the control. However, pretreatment of for 8 h improved survival against via inhibition intracellular production. Hispidin also inhibited...
Abstract Background To date, no effective curative option is available for children with neuroblastoma (NB) who failed tandem high‐dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT). The present study evaluated the feasibility efficacy of reduced‐intensity allogeneic (RI alloSCT) in six NB HDCT/autoSCT. Procedure A cyclophosphamide/fludarabine regimen was used as a conditioning HLA‐matched SCT, ATG added haploidentical SCT. Peripheral blood cells from four donors two...
The efficacy and toxicity of high-dose chemotherapy autologous stem cell transplantation (HDCT/ASCT) were investigated for improving the outcomes patients with relapsed medulloblastoma.A total 15 medulloblastoma enrolled in KSPNO-S-053 study from May 2005 to 2007.All received approximately 4 cycles salvage after relapse.Thirteen underwent HDCT/ASCT; CTE CM regimen employed first HDCT (HDCT1) second (HDCT2), respectively, 7 HDCT2.One transplant related mortality (TRM) due veno-occlusive...
Among the many environmental stresses, excessive production of reactive oxygen species (ROS) and ensuring oxidative stress are known to cause significant cellular damage. This has clinical implications in onset type 1 diabetes, which is triggered by destruction pancreatic β-cells associated with stress. In this study, we investigated protective antioxidative effects mulberry extract (ME) insulin-producing β-cells. We found that ME protects against hydrogen peroxide (H2O2)-induced apoptotic...
Leaves from Camellia sienensis are a popular natural source of various beverage worldwide, and contain caffeine polyphenols derived catechin analogues. In the current study, (CAF, 1) three tea including (−)-epigallocatechin 3-O-gallate (EGCg, 2), (−)-gallocatechin (GCg, 3), (−)-epicatechin (ECg, 4) were isolated purified by flow-rate gradient high-performance countercurrent chromatography (HPCCC) using two-phase solvent system composed n-hexane–ethyl acetate–methanol–water (1:9:1:9, v/v)....
BACKGROUND Hereditary hemolytic anemia (HHA) is a rare disease characterized by premature red blood cell (RBC) destruction due to intrinsic RBC defects. The Disorder Working Party of the Korean Society Hematology established and updated standard operating procedure for making an accurate diagnosis HHA since 2007. aim this study was investigate nationwide epidemiology HHA. METHODS We collected data newly diagnosed pediatric cohort (2007-2016) compared cohort's characteristics with those...
<h2>Abstract</h2> Hematopoietic stem cell transplantation (HSCT) is a curative therapy for severe aplastic anemia (SAA); however, the optimal conditioning regimen HSCT with an unrelated donor has not yet been defined. A previous study using fludarabine (FLU), cyclophosphamide (Cy), and antithymocyte globulin (ATG) (study A: 50 mg/kg Cy once daily i.v. on days −9, −8, −7, −6; 30 mg/m<sup>2</sup> FLU −5, −4, −3, −2; 2.5 of ATG −2, −1) demonstrated successful engraftment (100%) but had high...