A5010572665- Acute Lymphoblastic Leukemia research
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Iron Metabolism and Disorders
- Molecular Sensors and Ion Detection
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Glioma Diagnosis and Treatment
- Testicular diseases and treatments
- Trypanosoma species research and implications
- Hepatitis B Virus Studies
- Immunodeficiency and Autoimmune Disorders
- Neutropenia and Cancer Infections
- Lysosomal Storage Disorders Research
- Erythropoietin and Anemia Treatment
- Advanced biosensing and bioanalysis techniques
- Neonatal Health and Biochemistry
- Inhalation and Respiratory Drug Delivery
- Research on Leishmaniasis Studies
- Congenital Diaphragmatic Hernia Studies
- Cancer, Hypoxia, and Metabolism
- Luminescence and Fluorescent Materials
- Multiple Myeloma Research and Treatments
- Cancer therapeutics and mechanisms
CHA Bundang Medical Center
2016-2024
CHA University
2016-2024
BAE Systems (Sweden)
2019
Samsung Medical Center
2012-2015
Sungkyunkwan University
2014-2015
Pediatrics and Genetics
2015
Chung-Ang University
2009-2012
To evaluate the optimal timing of mesenchymal stem cell (MSC) transplantation following stroke, rats were transplanted with MSCs at 1 (D1), 4 (D4), and 7 days (D7) after middle cerebral artery occlusion (MCAo). Rats in D1 group showed a better functional recovery than those D4 or D7 groups MCAo. preferentially migrated to cortex group, while striatum. Interestingly, level monocyte chemotactic protein-1 (MCP-1) was highest day MCAo, stromal cell-derived factor-1 (SDF-1) striatum lowest MCAo...
Cytidine triphosphate (CTP) stabilized-Au nanoparticles (CTP-AuNPs) allow a quantitative assay of Ca2+ down to concentration 10−4 M with high selectivity towards ions over various metal including Mg2+ and the detection range this probe also can be easily tuned by changing CTP.
We aimed to identify the impact of NUDT15 variants on thiopurine intolerance and 6-thioguanine nucleotide (6-TGN) levels in Korean children with acute lymphoblastic leukemia (ALL).Genotyping was tested 258 patients ALL registered at Samsung Medical Center. Patients were classified into normal-activity (wild-type), intermediate-activity (heterozygous variant), low-activity groups (homozygous or compound heterozygous variant). Clinical laboratory features during first year maintenance therapy...
Thiopurine S-methyltransferase (TPMT) is a cytoplasmic enzyme involved in the metabolism of thiopurine drugs and its activity largely influenced by polymorphisms TPMT gene. To date, more than 35 variants are known to be associated with reduced activity, but most studies on genotype have included only common nonfunctional variants, such as TPMT*2 TPMT*3. In this study, we carried out complete sequencing analysis screen all Korean patients. A total 900 patients were genotyped for 30 (3.3%) had...
Iron deficiency (ID) tends to be overlooked compared with anemia. However, its prevalence is estimated twice as high that of ID anemia, and without anemia can accompanied by clinical functional impairments. The symptoms are nonspecific, such fatigue lethargy, but lead neurodevelopmental disorders in children, restless legs syndrome, recurrent infections due immune system dysregulation. In particular, the risk context chronic inflammatory diseases (CIDs) reaction various cytokines resulting...
The purpose of this study is to investigate the clinical significance tyrosine hydroxylase (TH) expression in peripheral blood (PB) at diagnosis patients with neuroblastoma. TH mRNA PB was measured by reverse transcription quantitative real-time polymerase chain reaction 210 who were newly diagnosed neuroblastoma from July 2005 June 2015 and evaluated. positive 60 (28.6%). Fifty TH-positive had metastatic tumors remaining 10 localized tumors. associated high-risk features (i.e., advanced...
The mercury prize: A highly selective and sensitive unmodified gold-nanoparticle (AuNP)-based colorimetric sensor for Hg2+ ions in aqueous media uses the Hg2+-promoted desulfurization reaction of a thiourea derivative reactivity to gold nanoparticles. This also allows quantitative assay analyte neutral solution, down concentration 10−7 M.
BACKGROUND Hereditary hemolytic anemia (HHA) is a rare disease characterized by premature red blood cell (RBC) destruction due to intrinsic RBC defects. The Disorder Working Party of the Korean Society Hematology established and updated standard operating procedure for making an accurate diagnosis HHA since 2007. aim this study was investigate nationwide epidemiology HHA. METHODS We collected data newly diagnosed pediatric cohort (2007-2016) compared cohort's characteristics with those...
Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is rare lysosomal storage disorder caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency. Only a few MPS cases have been reported in the Korean literature; there paucity of research about clinical or radiologic findings for this disorder. Therefore, we studied findings, radiological features, and genetic data patients determining factors that may allow early diagnosis thus improve patients' quality life.MPS was confirmed via...
Significance of Persistent Tumor in Bone Marrow during Treatment High-risk NeuroblastomaThe records 63 high-risk neuroblastoma patients with bone marrow (BM) tumors at diagnosis were retrospectively reviewed.All received nine cycles induction chemotherapy followed by tandem high-dose and autologous stem cell transplantation (HDCT/auto-SCT).Follow-up BM examination was performed every three months for one year after the second HDCT/auto-SCT.BM tumor cells persisted 48.4%, 37.7%, 23.3%, 20.4%...
Iron deficiency anemia (IDA) is a common medical problem that affects an estimated 30-50% of the world's population.The causes IDA are malnutrition, rapid growth with improper dietary iron, blood loss through gastrointestinal tract or menstruation.The genetic factors iron-refractory iron have also been identified.Previous studies on theory hepcidin-based homeostatic regulation helped increase our understanding metabolism.Symptoms may include non-specific symptoms, such as pale appearance,...
Background: We investigated the treatment outcomes before and after addition of amikacin to cefepime monotherapy as an initial empirical antibiotic in pediatric cancer patients with febrile neutropenia. Methods: This was a retrospective historical cohort study. The subjects were who visited emergency room at Samsung Medical Center, Seoul, Korea, due chemotherapy-induced neutropenia, between January 2011 December 2016. Since September 2014, antimicrobial regimen for neutropenia changed from...
Abstract Background Children with cancer may be at an increased risk of infection hepatitis B virus (HBV) when levels antibodies are reduced owing to chemotherapy‐induced immunosuppression. This study evaluated the changes in HBV antibody status and infections after chemotherapy children acute lymphoblastic leukemia (ALL). Procedure The data patients ALL diagnosed between April 2007 March 2013 were retrospectively collected. Hepatitis surface (HBsAb) titers defined as negative <10 IU/L....
Abstract Background Associations between anemia and allergic diseases have been reported, but the relationship of iron deficiency with airway dysfunction in children remains unclear. We aimed to investigate abnormal parameters lung function schoolchildren. Methods Four hundred forty‐five (10–12 years‐old) from 11 elementary schools were enrolled. The relationships different (hemoglobin, serum iron, transferrin saturation, ferritin) evaluated by impulse oscillometry (airways resistance at 5...
Purpose To evaluate the outcomes and prognostic factors in children with extracranial germ cell tumors (GCTs) treated at a single institution. Methods Sixty-six diagnosed GCTs between 1996 2012 were included study. Primary treatment was surgical excision, followed by six cycles of cisplatin-based chemotherapy. The survival rates compared according to International Germ Cell Cancer Cooperative Group classification used for adults validate guidelines children. Results median patient age 4.4...
Hematopoietic stem cell transplantation (HSCT) has been an important method of treatment in the advance pediatric acute lymphoblastic leukemia (ALL).The indications for HSCT are evolving and require updated establishment.In this study, we aimed to investigate efficacy on outcome ALL, considering subgroups.
Recent treatments for pediatric acute lymphoblastic leukemia (ALL) are founded on risk stratification. We examined the survival rates and prognostic factors of patients over a 20-year period at single institution.
In order to clarify the optimal timing for peripheral blood stem cell (PBSC) collection, PBSC collection records of 323 children who were scheduled undergo autologous transplantation from two study periods differing in analyzed. early period (March 1998 August 2007, n=198), was initiated when WBC count exceeded 1,000/µL during recovery chemotherapy. Findings this indicated that initiation at a higher might result greater CD34(+) yield. Therefore, late (September 2007 December 2012, n=125),...