A5103251172- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Tumors and Oncological Cases
- Tracheal and airway disorders
- Pituitary Gland Disorders and Treatments
- Teratomas and Epidermoid Cysts
- Vascular Malformations Diagnosis and Treatment
- Epilepsy research and treatment
- Neurofibromatosis and Schwannoma Cases
- Soft tissue tumor case studies
- Congenital Diaphragmatic Hernia Studies
- Head and Neck Surgical Oncology
- Hedgehog Signaling Pathway Studies
- Pharmacological Effects and Toxicity Studies
- Testicular diseases and treatments
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Congenital Heart Disease Studies
- Ocular Oncology and Treatments
- Sarcoma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Gestational Trophoblastic Disease Studies
- Alzheimer's disease research and treatments
- Cerebrospinal fluid and hydrocephalus
Samsung Medical Center
2015-2024
Sungkyunkwan University
2015-2024
University of Wisconsin–Madison
2008-2010
Samsung (South Korea)
2007
Biomedical Research Institute
2007
Seoul National University
1993
Overexpression of cyclooxygenase 2 (COX2) and uncontrolled wingless Int (Wnt)-signaling pathway have long been suggested to play crucial roles in colorectal cancer.Studies show that selective COX2 inhibitors possess great potential as chemopreventive agents for colon cancer.Recent studies suggest targeting epidermal growth factor receptor (EGFR) may provide better therapeutic strategy than inhibiting either single target this alleviate the problem inhibitor-associated side effects.Therefore,...
The mammalian target of rapamycin (mTOR) kinase is an important component PTEN/PI3K/Akt signaling pathway, which frequently deregulated in prostate cancer (CaP). Recent studies suggest that targeting and mTOR pathway could be effective strategy for the treatment hormone refractory CaP. Here, we show androgen-independent PTEN-negative human CaP PC3 cells with fisetin, a dietary flavonoid, resulted inhibition pathway. Treatment fisetin inhibited activity downregulated Raptor, Rictor, PRAS40...
The authors investigated whether expression of c-Met protein in glioblastomas is associated with overall survival and biologic features representing tumor invasiveness patients glioblastomas.Paraffin-embedded specimens from 62 treated a single institution were assessed by immunohistochemical (IHC) analysis expression. On the basis clinical data for these patients, association between clinicobiologic was analyzed.c-Met overexpression detected 29.0% (18 62) glioblastomas. In overexpression,...
To verify the pathologic features, anaplastic lymphoma kinase (ALK) expression and biologic behavior of inflammatory myofibroblastic tumors (IMTs) central nervous system (CNS), we analyzed 10 cases IMTs-CNS (8 cranial, 1 spinal, orbital). Our series IMTs CNS showed a male predominance (male:female = 6:4) wide age range (10-60 years; mean age, 46.7 years). Lesion location also varied, but they were basically dura-based. Radiologically, two patterns: isolated mass forming (n 6) an en...
Surgical treatment of cortical dysplasia (CD) together with intractable seizures is challenging because both visualization and localization the lesion are difficult, correlation seizure foci requires comprehensive study, surgical outcomes reported thus far unsatisfactory. The authors report their experience in CD classified according to a point view.The definition used this study was dysplastic visible on magnetic resonance (MR) images or that, although not MR images, diagnosed as...
Aims Clear cell meningioma ( CCM ) is a rare subtype of and shows not only unusual histology, but also unique clinical features. Recently, SMARCE 1 mutations have been shown to cause spinal cranial s. We present 12 cases which were diagnosed with in single institution between 1997 2014, investigate their mutation status. Methods results To the status these tumours, we used combination Sanger sequencing multiplex ligation‐dependent probe amplification analysis performed immunohistochemical...
Purpose We prospectively evaluated the effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in improving survival patients with atypical teratoid/rhabdoid tumors while reducing risks late adverse effects from radiotherapy (RT). Materials Methods For young children (< 3 years old), HDCT/auto-SCT was administered after six cycles induction chemotherapy. RT deferred until age unless tumor showed relapse or progression. older (> including...
BackgroundThyroid-stimulating hormone (TSH)-secreting pituitary neuroendocrine tumor (TSH PitNET) is a rare subtype of Pit- NET. We investigated the comprehensive characteristics and outcomes TSH PitNET cases from single medical center. Also, we compared diagnostic methods to determine which showed superior sensitivity. MethodsA total 17 patients diagnosed with after surgery between 2002 2022 in Samsung Medical Center was retrospectively reviewed. Data on treatment were collected. The...
Pulmonary hypertension (PH) is characterized by structural and functional changes in the lung including proliferation of vascular smooth muscle cells (VSMCs) excessive collagen synthesis. Although connective tissue growth factor (CTGF) known to promote cell proliferation, migration, adhesion, extracellular matrix production various tissues, studies on role CTGF pulmonary have been limited. Here, we examined expression tissues male Sprague Dawley rats treated with monocrotaline (MCT, 60...
The endothelium has emerged recently as a therapeutic target in the treatment of hypertension because endothelial dysfunction and subsequent vascular rarefaction cause organ damage further elevate blood pressure (BP). It led us to hypothesize that one survival factors, potent derivative angiopoietin-1 (cartilage oligomeric matrix protein, COMP-Ang-1), could be novel class antihypertensive agents maintain integrity function, thereby preventing development damage. To study role COMP-Ang-1...
Our goal was to investigate the correlation between dysregulation of transforming growth factor-β1 (TGF-β1) and cystic medial degeneration in aortic aneurysmal tissues Marfan syndrome (MFS) patients. Although aneurysm animal models MFS is related TGF-β, it has yet be determined whether TGF-β correlates with pathogenic characteristics patients.Compared tissue from normal individuals, layers patients exhibited profound cellular apoptosis. These histopathologic changes positively correlated...
The prognostic significance of IDH1 mutations has been demonstrated in gliomas. It is unclear whether mutation also a factor gliomatosis cerebri (GC). Primary GCs can be grouped into type 1 GCs, which have the classical diffuse growth pattern without mass formation, and 2 form neoplastic masses addition to classic lesions. In this study, relevance IDH1/2 74 (43 31 2) was evaluated. We detected 33 (44.6%) mutations, including R132H R132S, by bidirectional Sanger sequencing. No were IDH2....