A5039330242- Hemoglobinopathies and Related Disorders
- Neuroblastoma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Iron Metabolism and Disorders
- Neonatal Health and Biochemistry
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Adrenal and Paraganglionic Tumors
- Acute Lymphoblastic Leukemia research
- Cancer, Hypoxia, and Metabolism
- Testicular diseases and treatments
- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Heavy Metal Exposure and Toxicity
- Ocular Oncology and Treatments
- Sexuality, Behavior, and Technology
- Pediatric Urology and Nephrology Studies
- Adolescent Sexual and Reproductive Health
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- interferon and immune responses
- Glioma Diagnosis and Treatment
Inje University Haeundae Paik Hospital
2024
Dong-A University
2014-2023
Dong-A University Hospital
2014-2021
ORCID
2020
Samsung Medical Center
2009-2013
Sungkyunkwan University
2009-2013
Samsung (South Korea)
2009
The role of diet in the behavior children has been controversial, but association several nutritional factors with childhood behavioral disorders continually suggested. We conducted a case-control study to identify dietary patterns associated attention deficit hyperactivity disorder (ADHD). included 192 elementary school students aged seven 12 years. Three non-consecutive 24-h recall (HR) interviews were employed assess intake, and 32 predefined food groups considered principal components...
Current diagnostic tests for hereditary spherocytosis (HS) focus on the detection of hemolysis or indirectly assessing defects membrane protein, whereas direct methods to detect protein are complicated and difficult implement. In present study, we investigated patterns genetic variation associated with HS among patients clinically diagnosed HS. Multi-gene targeted sequencing 43 genes (17 RBC protein-encoding genes, 20 enzyme-encoding six additional differential diagnosis) was performed using...
Abstract Background Anemia is associated with high morbidity and mortality in older people. However, the prevalence characteristics of anemia individuals are not fully understood, national data on these aspects Korean adults lacking. This study aimed to evaluate using from Korea National Health Nutrition Examination Survey (KNHANES), which a nationwide cross-sectional epidemiological conducted by Ministry Welfare. Methods Data total 62,825 participants 2007–2016 KNHANES were compiled...
Purpose This study investigated the incidence trends and associated factors of type 1 (T1DM) 2 diabetes mellitus (T2DM) in children adolescents under 15 years age Busan Gyeongnam, Korea from 2001 to 2010. Methods Medical records newly diagnosed patients (n=328; 160 males, 168 females) were collected questionnaire form 5 tertiary 42 general hospitals Gyeongnam. Results The average crude rate T1DM T2DM was 2.01/100,000 (95% confidence interval [CI], 1.76-2.28) 0.75/100,000 CI, 0.60-0.92),...
Because the developing brain of a child is vulnerable to environmental toxins, even very low concentration neurotoxin can affect children's neurodevelopment. Lead neurotoxic heavy metal which has harmful effect on striatal-frontal circuit brain. This area known be closely related attention deficit hyperactivity disorder (ADHD) pathophysiology. The primary objective present study was investigate whether elevated blood lead risk factor for ADHD. secondary examine association between and...
Purpose Dexrazoxane has been used as an effective cardioprotector against anthracycline cardiotoxicity. This study intended to analyze cardioprotective efficacy and secondary malignancy development, elucidate risk factors for malignancies in dexrazoxane-treated pediatric patients. Materials Methods Data was collected from 15 hospitals Korea. Patients who received any anthracyclines, completed treatment without stem cell transplantation were included. For evaluation, the incidence of cardiac...
Exposure to heavy metals such as lead, cadmium, and mercury poses serious health risks pregnant women because of their high toxicity. In this study, we investigated the associations metal exposure with birth outcomes Korean infants. Data 5,215 between 2015 2019 were analyzed. This study was part Children's Environmental Health (Ko-CHENS) study. Linear regression logistic analyses used examine effects concentrations on weight, small for gestational age, large age after adjusting maternal...
Abstract Background To date, no effective curative option is available for children with neuroblastoma (NB) who failed tandem high‐dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT). The present study evaluated the feasibility efficacy of reduced‐intensity allogeneic (RI alloSCT) in six NB HDCT/autoSCT. Procedure A cyclophosphamide/fludarabine regimen was used as a conditioning HLA‐matched SCT, ATG added haploidentical SCT. Peripheral blood cells from four donors two...
BACKGROUND Hereditary hemolytic anemia (HHA) is a rare disease characterized by premature red blood cell (RBC) destruction due to intrinsic RBC defects. The Disorder Working Party of the Korean Society Hematology established and updated standard operating procedure for making an accurate diagnosis HHA since 2007. aim this study was investigate nationwide epidemiology HHA. METHODS We collected data newly diagnosed pediatric cohort (2007-2016) compared cohort's characteristics with those...
Patients with hematologic malignancies who relapse after their first hematopoietic stem cell transplantation tend to have poor prognoses. One option for these patients is a second allogeneic (allo-HSCT). However, there are few reports of allo-HSCT therapy in children relapsed malignancies. Patient outcomes 27 individuals acute leukemia received at least 2 allo-HSCTs the Samsung Medical Center between May 1997 and September 2010 were analyzed retrospectively. After median follow-up 33 months,...
For children and adolescents with cancer, going back to school is a key milestone in returning "normal life."To identify the support vital for successful transition, we evaluated parents' needs challenges they face when their return school.This multi-institutional study was conducted by Korean Society of Pediatric Hematology Oncology. The written survey comprised 24 questions completed 210 parents without an interviewer.Most (165 206) reported that experienced difficulties physical status...
Abstract Background We evaluated whether iron chelation treatment during induction chemotherapy could safely reduce serum levels and thereby the frequency of hepatic veno‐occlusive disease (VOD) high‐dose autologous stem cell transplantation (HDCT/autoSCT) in children with high‐risk solid tumors. Procedure Children diagnosed tumors between August 2008 July 2009 were enrolled. Deferasirox (25 mg/kg/day) was initiated when ferritin increased to more than 1,000 ng/ml chemotherapy. Patients who...
Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) enhance the engraftment of human hematopoietic (HSCs) when they are cotransplanted in animal and studies. However, type MSCs that preferentially facilitate homing HSCs is largely unknown. The authors categorized UCB-MSCs as least-effective (A) or most-effective (B) at enhancing HSCs, compared gene expression profiles various cytokines growth factors UCB-MSC populations. secreted higher levels several factors, including...
Multiple RBC transfusions inevitably lead to a state of iron overload before and after high-dose chemotherapy autologous stem cell transplantation (HDCT/autoSCT). Nonetheless, status during post-SCT follow-up remains unknown. Therefore, we investigated ferritin levels, factors contributing its sustained organ functions affected by in 49 children with high-risk neuroblastoma who underwent tandem HDCT/autoSCT. Although serum levels gradually decreased follow-up, 47.7% the patients maintained...
Background A disintegrin and metalloprotease (ADAM) is a multifunctional gene family that contributes to the homeostasis of extracellular matrix, transduction specific intracellular signals, organogenesis, inflammation, tissue remodeling, adhesion, cell migration. ADAM17 best characterized sheddase, with widespread putative substrates, including various inflammatory modulators. ADAM10 most similar ADAM in terms both protein sequence structural properties their catalytic domains. The...
Background The “a disintegrin and metalloproteases” (ADAMs) are a multifunctional gene family that contribute to the homeostasis of extracellular matrix, transduction specific intracellular signals, organogenesis, inflammation, tissue remodeling, adhesion, cell migration. ADAM17 is best-characterized “sheddases,” its putative substrates widespread, including various inflammatory modulators. ADAM10 most similar in terms protein sequence structural properties their catalytic domains. objective...
TRAIL [TNF (tumour necrosis factor)-related apoptosis-inducing ligand] is a promising agent for clinical use since it kills wide range of tumour cells without affecting normal cells. We provide evidence that pretreatment with etoposide significantly enhanced TRAIL-mediated apoptosis via up-regulation DR5 (death receptor 5 or TRAIL-R2) expression in the caspase 8 expressing neuroblastoma cell line, SK-N-MC. In addition, sequential treatment and increased caspases 8, 9 3 activation, Mcl-1...
Purpose Iodine is a major component of thyroid hormones. Both deficiency and excess iodine are risk factors for disease, making it important to accurately assess level in the human body. Urinary concentration (UIC) commonly used measure status. However, there little research on status related characteristics Korean adolescents. Methods Using data from sixth Korea National Health Nutrition Examination Survey (KNHANES VI) years 2013â2015, we analyzed UIC function test results adolescents...
Mitotane is an adrenolytic drug that exhibits therapeutic effects within a narrow target range (14-20 μg/dL). Various complications develop if the upper limit exceeded. We present case of 5-year-old girl with breast development, acne, and pubic hair who was diagnosed adrenal mass subsequently excised. The pathological finding adrenocortical carcinoma high risk malignancy, adjuvant therapy (combined mitotane radiation therapy) recommended. initiated at low dose to allow monitoring level,...
Purpose : This study investigated the clinical significance of AN in children and adolescents with obesity induced metabolic complications. Methods Forty-nine patients who had complications were participated this cross-sectional study. Obesity are as follows: hypertension, dyslipidemia, impaired fasting glucose (IFG), tolerance (IGT), nonalcoholic steatohepatitis (NASH), homeostasis model assessment insulin resistance (HOMA-IR)>3.16. Clinical characteristics, such as, age,...
Purpose This study evaluated the effect of first nocturnal ejaculation timing on risk and sexual behaviors Korean male adolescents. Methods We analyzed data from 10th edition Korea Youth Risk Behavior Web-based survey that was conducted with high school adolescents in grades 10â12. The included 17,907 adolescents, 10,326 responded their experience ejaculation. Of these, 595 had â¤grade 4 (âearly pubertyâ) 9,731 â¥grade 5 (ânormal pubertyâ). differences between these 2 groups...
Acute myeloid leukemia (AML) is the second most common pediatric leukemia, with a survival rate of 70%. In this retrospective study, we evaluated treatment outcomes AML among 144 patients diagnosed between 2000 and 2013. After induction, 80.6% achieved complete remission (CR). The 5-year overall (OS) event-free (EFS) rates were 58.8 ± 4.2% 49.8 4.2%, respectively. Based on response to induction therapy, OS was 66.9 5.7% in CR (p < 0.001). Ninety-nine after therapy examined, their EFS 66.4...