A5101951166- Mesenchymal stem cell research
- Virus-based gene therapy research
- Cell death mechanisms and regulation
- Peroxisome Proliferator-Activated Receptors
- Neonatal Respiratory Health Research
- interferon and immune responses
- Hematopoietic Stem Cell Transplantation
- Neuroblastoma Research and Treatments
- Tissue Engineering and Regenerative Medicine
- bioluminescence and chemiluminescence research
- Drug Transport and Resistance Mechanisms
- Tryptophan and brain disorders
- RNA Interference and Gene Delivery
- Occupational Health and Safety Research
- Amyotrophic Lateral Sclerosis Research
- Marine and Coastal Research
- Heavy Metal Exposure and Toxicity
- Education and Learning Interventions
- Chemokine receptors and signaling
- Cancer Mechanisms and Therapy
- Infectious Encephalopathies and Encephalitis
- Occupational Health and Performance
- Trace Elements in Health
- Sleep and related disorders
- Osteoarthritis Treatment and Mechanisms
Sungkyunkwan University
2010-2023
Samsung Medical Center
2010-2023
Korea University
2020
Samsung (South Korea)
2009
National Cancer Center
2008
Korea Occupational Safety and Health Agency
2000-2007
Konkuk University
1998
Abstract Akt/protein kinase B signaling is very important for cancer cell survival and growth when cells are exposed to various apoptotic stimuli. Akt constitutively activated in NSCLC a potential target enhancing the cytotoxicity of chemotherapeutic agents treatment NSCLC. In our study, we investigated whether down‐regulating Akt1 using RNAi techniques can enhance sensitivity cisplatin cells. An siRNA targeting significantly decreased protein level activity ERK. Treatment these with 20 μM...
A microarray analysis was performed to investigate whether ex vivo culture conditions affect the characteristics of MSCs. Gene expression profiles were mainly influenced by level cell confluence rather than initial seeding density. The showed that 276 genes upregulated and 230 downregulated in MSCs harvested at<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mo>~</mml:mo></mml:mrow></mml:math>90% versus<mml:math...
In vivo leukemia mouse models are usually generated by intraperitoneal (IP) or intravenous (IV) injection of cells. However, the pattern development observed can be inconsistent. This study investigated directly into bone marrow [intra-bone transplantation (IBMT)], natural microenvironment leukemia. A bioluminescent imaging-based animal model has been established direct a cells (CCRF-CEM/fLuc) NOD/SCID tibia and compared with IP IV routes. The comparison revealed that in via IBMT could...
Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) enhance the engraftment of human hematopoietic (HSCs) when they are cotransplanted in animal and studies. However, type MSCs that preferentially facilitate homing HSCs is largely unknown. The authors categorized UCB-MSCs as least-effective (A) or most-effective (B) at enhancing HSCs, compared gene expression profiles various cytokines growth factors UCB-MSC populations. secreted higher levels several factors, including...
TRAIL [TNF (tumour necrosis factor)-related apoptosis-inducing ligand] is a promising agent for clinical use since it kills wide range of tumour cells without affecting normal cells. We provide evidence that pretreatment with etoposide significantly enhanced TRAIL-mediated apoptosis via up-regulation DR5 (death receptor 5 or TRAIL-R2) expression in the caspase 8 expressing neuroblastoma cell line, SK-N-MC. In addition, sequential treatment and increased caspases 8, 9 3 activation, Mcl-1...
The potential of human mesenchymal stem cells (MSCs) for cell therapy has been investigated in numerous immune-mediated conditions; MSCs are considered one the most promising cellular therapeutics to treat intractable diseases. Recently, approaches prime have investigated, thereby generating products with enhanced a variety clinical applications. Interferon-gamma (IFN-γ) priming is current approach used increase therapeutic efficacy MSCs. In this study, we determined systemic toxicity,...
Abstract Objectives This study aims to explore the roles of N‐myc and caspase‐8 in TRAIL‐resistant IMR‐32 cells which exhibit MYCN oncogene amplification lack expression. Materials methods We established N‐myc–downregulated using shRNA lentiviral particles targeting examined effect inhibition on TRAIL susceptibility human neuroblastoma expressing caspase‐8. Results Cisplatin treatment increased expression death receptor 5 (DR5; TRAIL‐R2), but not other receptors, via downregulation NF‐κB...
Objectives Advanced clinical management has increased the survival rate of premature infants. Mothers infants have more concerns about their infant's health, which may impair sleep quality. This study aimed to investigate quality Korean mothers after neonatal intensive care unit (NICU) discharge. Methods Face-to-face interviews were conducted for 90 corrected aged 0–12 months who born at <37 weeks gestation and had been discharged from NICU. The questionnaire consisted general background...
1 ) O b j e c t i v s : The aims of this study were to investigate the occupational exposure level toluene among rotogravure printers and neurobehavioral effects them. M h o d Fifty 147 controls participated in study. Environmental biological monitoring was performed for investigation expo - sure level, performance test by using Behavioral Assessment Research System with Korean language instructions(BARS-K). Results: major results as follows; 1. Geometric mean concentrations ambient air 5...
Abstract Ciglitazone (CGZ), peroxisome proliferator-activated receptor γ (PPARγ) agonist, is recognized to regulate multiple signal pathways and induce apoptosis in various cancer cells. CGZ induces apoptotic cell death through binding PPARγ, but interdependence between PPARγ not clear. In this study, over 30 εM observed significant cytotoxicity T98G line, below 25 µM. Cotreatment with 20 µM GW9662, an antagonist of synergistically induced death. However, treatment GW9662 significantly...
Abstract Mesenchymal stem cells (MSCs), which evoke only minimal immune reactivity, may have anti-inflammatory and immunomodulatory effects. In this study, we conducted a comparative analysis of the properties MSCs derived from adult human tissues including bone marrow (BM), adipose (AT), umbilical cord blood (CB), Wharton's jelly (WJ). Using multiple cytokine detection assay, showed that there were no significant differences in levels secreted factors non-stimulated MSCs. We compared...