A5033381537- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Blood groups and transfusion
- Neutropenia and Cancer Infections
- Glioma Diagnosis and Treatment
- Influenza Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral-associated cancers and disorders
- Childhood Cancer Survivors' Quality of Life
- Respiratory viral infections research
- Hematopoietic Stem Cell Transplantation
- Transplantation: Methods and Outcomes
- Platelet Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Iron Metabolism and Disorders
- Antifungal resistance and susceptibility
- Neonatal Respiratory Health Research
- Injury Epidemiology and Prevention
- Traffic and Road Safety
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Menstrual Health and Disorders
- Preterm Birth and Chorioamnionitis
Kosin University
2016-2023
Kosin University Gospel Hospital
2017-2023
Pusan National University
2010-2014
Abstract Background Transplantation-related mortality (TRM) is a major obstacle in allogeneic hematopoietic cell transplantation (allo-HCT). Approximately 60–80% of TRM occurs early, within 100 days transplantation. Methods This was nationwide population cohort study involving 5395 patients with acute leukemia who underwent allo-HCT between 2003 and 2015. Patient data were collected from the Korean National Health Insurance Service database. We investigated cumulative incidence rates (CIRs)...
Background Hyperleukocytosis caused by acute lymphoblastic leukemia (ALL) is associated with early morbidity and mortality due to hyperviscosity arising from the excessive number of leukocytes.This study was designed assess incidence hyperleukocytosis, survival outcomes, adverse features among pediatric ALL patients hyperleukocytosis. Methods Between January 2001 December 2010, 104 children previously untreated were enrolled at Pusan National University Hospital. All them initially...
Abstract Post-transplant malignancy (PTM) is a leading cause of premature mortality among kidney transplantation recipients. However, population-based cohort studies that cover incidence, mortality, and risk factors for PTM are rarely reported, especially in East Asia. We designed retrospective study using national database. A total 9915 recipients between 2003 2016 were included. During this period, 598 cases (6.0%) de novo occurred. The most common was thyroid cancer (14.2%), followed by...
BACKGROUND Hereditary hemolytic anemia (HHA) is a rare disease characterized by premature red blood cell (RBC) destruction due to intrinsic RBC defects. The Disorder Working Party of the Korean Society Hematology established and updated standard operating procedure for making an accurate diagnosis HHA since 2007. aim this study was investigate nationwide epidemiology HHA. METHODS We collected data newly diagnosed pediatric cohort (2007-2016) compared cohort's characteristics with those...
Thalassemia is highly prevalent in Southeast Asia but rare Korea; however, Asian immigrant population recently rising Korea. We investigated the prevalence of thalassemia Korea context increasing immigration.This prospective, observational, multicenter study was conducted between September 2015 and August 2017. A total 669 subjects <30 years living were grouped into multiethnic (N=314) Korean (N=355) groups. Hb electrophoresis complete blood count (CBC) performed. If low mean corpuscular...
Acute lymphoblastic leukemia (ALL) with hyperleukocytosis at diagnosis is associated early morbidity and mortality due to complications of leukostasis. Of 535 pediatric ALL patients (January 2004 December 2016 from the Yeungnam region Korea), 72 (13.5%) an initial white blood cell (WBC) count ≥100×10/L were included in this study, whom 38 had extreme (WBC>200×10/L) diagnosis. Fourteen (19.4%) ≥1 respiratory neurologic during induction therapy. Relapse occurred 8 (24.2%) 1 patient (3.0%) WBC...
The epidemiological features of Waldenström macroglobulinemia (WM) have seldom been investigated at a national level, particularly in East Asia. goal our study is to present the incidence, prevalence, mortality, survival with competing risks, and causes death patients WM.
Abstract Several guidelines classify autologous stem cell transplantation (ASCT) as a low to intermediate risk group for infection. In nationwide population-based study, using the Korean Health Insurance Review and Assessment Service database, patients with lymphoma multiple myeloma (MM) who underwent ASCT from 2002 2016 were retrospectively analyzed. Cumulative incidence rates (CIRs) factors of opportunistic infections investigated. CIRs fungal, Varicella zoster virus (VZV), cytomegalovirus...
Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between adult. We aimed to evaluate incidence, clinical treatment outcomes of pediatric APL Korea.Seventy-nine patients diagnosed from January 2009 December 2016 16 tertiary medical centers Korea were reviewed retrospectively.Of 801 acute myeloid children, 79 (9.9%) with APL. The median age at diagnosis was 10.6 years (range, 1.3 18.0). Male female ratio 1:0.93. Thirty (38.0%) had...
Purpose: Sepsis is a significant cause of morbidity and mortality in the newborn, particularly preterm. The objective this study was to analyze incidence rate, causative pathogens clinical features neonatal sepsis one intensive care unit (NICU) for 6 years. Methods: This retrospectively performed review laboratory characteristics including sex, gestational age, birth weight, Apgar score, length hospitalization, total parenteral nutrition, presence cen- tral venous catheter, underlying...
Hyerim Kim, M.D., In-Suk Chulhun L. Chang, Sun-Young Kong, Young Tak Lim, Seom Gim Eun Hae Cho, Eun-Yup Lee, Ho-Jin Shin, Hyeon Jin Park, Hyeon-Seok Eom, and Hyewon M.D.. Ann Lab Med 2019;39:125-32. https://doi.org/10.3343/alm.2019.39.2.125
This study investigated the clinical characteristics and risk factors of severity pandemic influenza A (H1N1) 2009 infection in pediatric patients Busan Gyeongsangnam-do.Cases under age 18 years, confirmed by reverse transcription polymerase chain reaction, at Pusan National University Hospital Yangsan from last week August through February 2010 were retrospectively analyzed.Of 3,777 cases 2009, 2,200 (58.2%) male 1,577 (41.8%) female. The average was 8.4±4.8 years. total peaked during 44th...
The use of proper safety restraint systems by children is vital for the reduction traffic accident-related injury and death. This study evaluated rates front seats Korean children.Based on data from National Health Nutrition Examination Survey 2008 to 2015, I investigated frequencies seat under six 12 years age, respectively.The percentage respondents who said they always increased 17.7% in 45.0% 2015. rate did not at all was 47.3 % compared 33.4% Multivariate logistic regression analysis...
Mortality at an early stage after kidney transplantation is a catastrophic event. Treatment-related mortality (TRM) within 1 or 3 months has been seldom reported. We designed retrospective observational cohort study using national population-based database, which included information about all recipients between 2003 and 2016. A total of 16,073 patients who underwent were included. The rates month (early TRM) 0.5% (n = 74) 1.0% 160), respectively. Based on multivariate analysis, older age...
Background: Anemia is an important health problem affecting approximately 25% of the global population. Although its prevalence decreasing worldwide, few studies have examined anemia in Korean adolescents.Purpose: This study aimed to determine adolescents over past 21 years using data from Korea National Health and Nutrition Examination Survey.Methods: We investigated aged 10–18 for period 1998–2018 according sex, age, residential area, household income. The effects menarche age menstruation...
Treatment Outcomes and Prognostic Factors in Children with Non-Hodgkin Lymphoma at a Single Institution Ji Sook Kim, M.D., Seom Gim Kong, Chi Eun Oh, Ho Yeon Yoo, M.D. Jae Sun Park, Department of Pediatrics, Kosin University College Medicine, Busan, Seoul Children’s Hospital, Jinhae, Dong-nam Institute Radiological & Medical Sciences, Korea
Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is one of the most fatal complications hematopoietic cell transplantation (HCT), and defibrotide only curative drug. We conducted this study to confirm survival rate VOD/SOS patients diagnosed in Korea assess efficacy defibrotide.Patients with after allogenic HCT between 2003 2020 were enrolled. investigated day +100 rates associated risk factors who satisfied modified Seattle criteria within 50 days HCT.A total 110 criteria,...
Objectives Systemic antibiotic therapy with semisynthetic penicillinase-resistant penicillin or vancomycin and clindamycin are recommended for the treatment of staphylococcal scalded skin syndrome (SSSS). This study assessed rate resistance Staphylococcus aureus isolated from anterior nares children diagnosed SSSS. Methods A retrospective review medical records 25 patients SSSS between July 2010 October 2014 was conducted. The clinical characteristics were collected susceptibility S....
Objectives: We aimed to evaluate treatment outcomes of pediatric acute lymphoblastic leukemia (ALL) subgroups by risk–stratification, in the Yeungnam region Korea. Methods: reviewed courses 409 newly diagnosed ALL patients from January 2004 December 2013 region. Results: All were classified into three risk groups: standard (SR, n=212), high (HR, n=153) and very (VHR, n=44). The mean follow-up time was 73.6 ± 39.4 months. 7-year event-free survival (EFS) overall (OS) rates 78.7 2.1% 86.8...
Injury is the leading cause of death or disability in children and adolescents. Rates deaths from injuries have recently declined, but studies occurrence nonfatal are lacking.This study aimed to investigate adolescents younger than 20 years based on data Korean National Health Nutrition Survey, 2007-2018.A questionnaire survey was conducted determine whether had experienced an injury requiring a hospital visit previous year. We investigated each injury's risk factors characteristics.Of total...
목적: 신생아 중환자실(neonatal intensive care unit, NICU)에서 인플루엔자 바이러스 집단 발병의보고는 흔하지 않으며 그 증상은 다양하다. 저자들은 국내 단일기관 NICU에서 발생한 A형 인플루엔자바이러스 감염의 집단발병에 대해 보고하고 특히 미숙아에서의 임상적 특성을 알아보고자 하였다. 방법: 2011-2012년 감염 유행 시기에 고신대학교 복음병원 NICU에 입원한 환자들 중 RT-PCR 검사를 시행한 29명 환자들의 의무기록을 후향적으로 조사하였다. 결과: 대상 환자 11명에서 양성이었는데(37.9%), 모두 미숙아였고 이들중 3명(27%)은 증상이 없었으며 상기도 증상 없이, 발열(18%, 2/11), 호흡곤란(72.7%, 8/11), 소화기 증상(27.3%, 3/11)이 있었다. 소실까지 기간의 중앙값은 5일이었다. 이들은 합병증없이 생존하여 퇴원하였다. 양성군과 음성군 사이에 검체 채취시재원기간, CRIB 점수, 기계환기 과거력, 덱사메타손...
Loeys-Dietz syndrome is a hereditary connective-tissue disorder first reported in 2005.It caused by genetic defects the transforming growth factor-beta (TGF-) signaling pathway.TGF- plays an important role development, differentiation, and homeostasis.Dysregulation of TGF- causes various skull, face, skeletal system, skin, blood vessels.Symptoms include scoliosis, spider finger, joint laxity, club foot, hypertelorism, cleft palate.In addition, aortic aneurysm, dissection, bleeding...