A5014044521- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- Polyomavirus and related diseases
- Transplantation: Methods and Outcomes
- Parvovirus B19 Infection Studies
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Hemoglobinopathies and Related Disorders
- Herpesvirus Infections and Treatments
- Neonatal Respiratory Health Research
- Erythrocyte Function and Pathophysiology
- Autoimmune and Inflammatory Disorders Research
- Blood disorders and treatments
- Neuroblastoma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Antifungal resistance and susceptibility
Catholic University of Korea
2016-2025
Seoul St. Mary's Hospital
2016-2025
All India Institute of Medical Sciences
2021
Daejeon St. Mary's Hospital
2020
Korea Health Industry Development Institute
2019
Ministry of Health and Welfare
2019
Institut de Recherche Vaccinale
2014
In-Q-Tel
2013
National University College
2011
Samsung Medical Center
2011
We identified principal genetic alterations in 97.1% (99/102) of patients with T-acute lymphoblastic leukemia (T-ALL) using integrative analyses, including massive parallel sequencing and multiplex ligation-dependent probe amplification (MLPA). A total 133 mutations were the following genes descending order: NOTCH1 (66.7%), FBXW7 (19.6%), PHF6 (15.7%), RUNX1 (12.7%), NRAS (10.8%), DNMT3A (9.8%). Copy number most frequently detected CDKN2B, CDKN2A, on 9p21.3 T-ALL (45.1%). Gene expression...
We analyzed a nationwide registry of pediatric patients with hemophagocytic lymphohistiocytosis (HLH) in Korea to assess the clinical and genetic features treatment outcomes HLH.The Histiocytosis Working Party retrospectively data on 251 diagnosed HLH between 1996 2011.In study cohort, 25 cases were categorized familial HLH, 64 presumed secondary 162 unspecified HLH. Of 217 evaluable patients, 91 (42%) had concomitant Epstein-Barr virus infection. 238 central nervous system (CNS)...
Abstract Background As neutropenia episodes in pediatric hemato-oncology often lead to sepsis and need antibiotics, monitoring resistance is crucial for empirical antibiotics choice. We analyzed antimicrobial susceptibility changes Enterobacterales from patients at Seoul St. Mary’s bone marrow (BMT) center. Data 2016-2020 2021-2023 were compared after shifting initial piperacillin-tazobactam (PIP-TZ) cefepime (CEF). Methods This was a retrospective cohort study of the BMT center hospital....
Although the proportion of Pseudomonas aeruginosa infections has reduced after introduction antibiotics with anti-pseudomonal effects, P. bacteremia still causes high mortality in immunocompromised patients. This study determined clinical characteristics and outcomes antibiotic susceptibilities strains isolated from febrile neutropenic patients.Thirty-one children adolescents underlying hematologic/oncologic disorders diagnosed between 2011 2016 were enrolled study. Their medical records...
A nationwide survey was conducted to clarify the clinical features and outcomes of Korean children with Langerhans cell histiocytosis (LCH). Korea Histiocytosis Working Party analyzed data 603 patients who were diagnosed LCH between 1986 2010 from 28 institutions in Korea. Median age at diagnosis 65 months (range, 0 276 mo). Bone most frequently affected organ (79.6%) followed by skin (19.2%). Initially, 419 (69.5%) had single-system involvement (SS), 85 (14.1%) multisystem (MS) disease...
Pre-engraftment syndrome (PES) is poorly characterized, and its clinical significance the prognostic impact after unrelated cord blood transplantation (CBT) are unclear. To address these issues, we retrospectively analyzed incidence, risk factors, outcomes of PES in CBT recipients. Data 381 patients who received from 18 medical centers Korea were reviewed. was defined as unexplained fever >38.3°C not associated with infection, and/or skin rash or without evidence fluid retention before...
Summary. The aim of this study was to evaluate the outcomes for Philadelphia‐chromosome‐positive acute lymphoblastic leukaemia (Ph + ALL) patients in remission treated with allogeneic bone marrow transplantation (BMT). Twenty‐three adults were entered onto study. 2‐year probabilities relapse and disease‐free survival (DFS) 39·4 ± 11·6% 43·5 10·3% respectively. presence chronic graft‐versus‐host disease (GVHD) found be an independent predictive factor affecting lower DFS. To monitor BCR‐ABL...
Self-renewal of hematopoietic stem cells (HSCs) is key to their reconstituting ability, but the factors regulating process remain poorly understood. Here, we show that Interleukin-10 (IL-10), a pleiotropic immune modulating cytokine, can also play role in HSC self-renewal. First, quantitative decrease primitive cell populations, not more matured cells, was observed bone marrows IL-10 disrupted mice as determined by long-term vitro cultures or vivo competitive repopulation assays. In...
Chronic graft-versus-host disease (cGVHD) is a potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation. Clinical data surrounding cGVHD therapies in younger children are limited and critically needed. Primary endpoints were to determine the recommended pediatric equivalent dose (RPED) assess pharmacokinetics (PK) safety. Secondary included overall response rate (ORR; comprising complete partial response) according 2014 National Institutes Health...
Antithymocyte globulin (ATG) has been used in severe aplastic anemia (SAA) as part of the conditioning regimen. Among many kinds ATG preparations, thymoglobulin had found to be more effective for preventing graft-versus-host disease (GVHD) and rejection organ transplants. After promising results our preliminary study, we conducted a phase II prospective multicenter clinical trial using fludarabine (Flu), cyclophosphamide (Cy), regimen allow good engraftment patients who underwent unrelated...
Chemoimmunotherapy-based treatments have improved the survival of patients with HLH, but outcomes are still unsatisfactory. We report here outcome Korean children HLH who underwent HSCT, which was analyzed from data a nation-wide registry. Retrospective recruitment for pediatric diagnosed between 1996 and 2008 carried out by Histiocytosis Working Party Society Hematology. Nineteen received HSCT among total 148 enrolled were transplant-related variables events. The probability five-yr after...
This study was performed to compare the clinical characteristics and antibiotic susceptibilities of viridans streptococcal bacteremia (VSB) between febrile neutropenic adults children with hematologic malignancies.The consecutive medical records patients malignancies who were admitted Catholic Blood Marrow Transplantation Center April 2009 July 2012, subsequently diagnosed VSB reviewed retrospectively. A comparison made laboratory pediatric also cefepime susceptible or not VSB.A total 202...
Background:The incidence of bacteremia caused by Gram-negative bacteria has increased recently in febrile neutropenic patients with the increase antibiotic-resistant bacterial infections.This study aimed to identify distribution causative and proportion diagnosed children. Materials Methods:The medical records children between 2010 2014 were retrospectively reviewed.The investigated compared yearly during period.The clinical impact infections was also determined.Results: A total 336 episodes...
Purpose Aplastic anemia (AA) is a rare hematologic disease characterized by pancytopenia and hypocellular marrow. The Korean Society of Pediatric Hematology Oncology investigated retrospectively the incidence, survival, transfusion independency according to treatment strategies in AA. Methods All questionnaires were sent members for medical records. We collected analyzed 702 available data. Results male female ratio was 1.2, median age at diagnosis 9.3 years. annual incidence children with...
Purpose Dexrazoxane has been used as an effective cardioprotector against anthracycline cardiotoxicity. This study intended to analyze cardioprotective efficacy and secondary malignancy development, elucidate risk factors for malignancies in dexrazoxane-treated pediatric patients. Materials Methods Data was collected from 15 hospitals Korea. Patients who received any anthracyclines, completed treatment without stem cell transplantation were included. For evaluation, the incidence of cardiac...
Long-term survivors of hematopoietic stem cell transplantation (HSCT) during childhood and adolescence are at risk developing endocrine complications. The purpose this study was to evaluate the long-term complications their associated factors among such patients. We reviewed data from 111 patients (59 males 52 females) who underwent HSCT mean age 8.3+/-4.1 yr. Thirty (27.0%) had growth impairment, seven (21.2%) out 33 attained final height reached below 2 standard deviation (SD). SD score...
We report the outcome of 236 pediatric umbilical cord blood transplantations (UCBT) performed in Korea. Given that sources grafts were mostly unrelated donors (n = 226; 95.8%), only results UCBT included for all statistics. The most frequent primary disease was acute leukemia 167). In total, 91.7% recipients seropositive cytomegalovirus (CMV). median doses nucleated cells and CD34+ 4.84 × 10(7)/kg 2.00 10(5)/kg, respectively. times to neutrophil (>0.5 10(9)/L) platelet recovery (>20 18 45...
Acute colonic pseudo-obstruction (ACPO) refers to dilatation of the colon and decreased bowel motility without evidence mechanical obstruction. Neostigmine, an acetylcholinesterase inhibitor, has been used in patients whom supportive therapy failed resolve ACPO. Here, we report results administering neostigmine treat ACPO children with hematologic malignancies.Between September 2005 December 2009, 10 (8 male 2 female) were diagnosed at Department Pediatrics, Catholic University Korea....