A5025377394- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Family Support in Illness
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Testicular diseases and treatments
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Glioma Diagnosis and Treatment
- Gestational Trophoblastic Disease Studies
- Cancer Risks and Factors
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Polyomavirus and related diseases
- Medical Imaging and Pathology Studies
- Congenital Anomalies and Fetal Surgery
- Ovarian cancer diagnosis and treatment
- Immunodeficiency and Autoimmune Disorders
- Tumors and Oncological Cases
- Nitric Oxide and Endothelin Effects
- Advanced MRI Techniques and Applications
- Cytomegalovirus and herpesvirus research
- Multiple and Secondary Primary Cancers
- Caveolin-1 and cellular processes
- Cancer-related gene regulation
Seonam University
2023
National Cancer Center
2013-2022
Seoul National University
2013
Cancer Research Institute
2013
National University College
2013
New Generation University College
2013
Cancer Research Institute of the Slovak Academy of Sciences
2013
National Cancer Center
2006
Purpose An epidemiologic study of childhood cancer would provide useful information on etiology and development management guidelines. Materials Methods Data from the Korea National Cancer Incidence Database were used to examine incidence survival in patients aged 0-14 years. Patients grouped according International Classification Childhood Cancer, 3rd edition. Age-specific age-standardized incidences per million estimated annual percentage change (APC) calculated by sex age. Five-year...
Background The nationwide statistical analysis of hematologic malignancies in Korea has not been reported yet. Methods Central Cancer Registry and the Korean Society Hematology jointly investigated domestic incidence rates prevalence occurred between 1999 2008, analyzed survival patients who were diagnosed 1993 2008. Data from to 2008 obtained National Incidence base. crude rates, age-specific age-standardized annual percentage change incidence, 1999-2008 calculated. Survival for 1993-2008...
Normal cells are sensitive to anoikis, which is a cell detachment-induced apoptosis. However, cancer acquire anoikis resistance that essential for successful metastasis. This study aimed demonstrate the function and potential mechanism of NADPH oxidase 4 (NOX4) EGFR activation in regulating lung cancer.Cells were cultured either attached or suspended condition. Cell viability was measured by counting live dead staining. Expression levels NOX4 PCR immunoblotting. Reactive oxygen species (ROS)...
Background In Korea, cancer is the third leading cause of death among adolescents and young adults (AYAs). However, incidence survival trends AYAs (15–29 years) have never been studied in Korea. Therefore, this study aimed to investigate relative rates their Materials Methods Cancer data from 1999–2010 were obtained Korea Central Registry (KCCR). Each was classified into subgroups according National Institute Surveillance, Epidemiology, End Results (SEER) AYA site recode. Percent...
Background Large-scale epidemiologic analysis for hematologic malignancies will be helpful to understand the trends in incidence and survival. Methods The Korea Central Cancer Registry (KCCR) updated nationwide on survival of myeloid malignancies, from Korean National Incidence Database between 1999 2012. Myeloid were classified based International Classification Diseases Oncology 3rd edition (ICD-O-3). Results Overall 3,771 cases diseases, which was 1.7% all cancers, identified highest...
The plasma membrane microdomains, lipid rafts, are involved in regulation of cellular functions such as cell survival and adhesion. Cholesterol is a critical component rafts terms their integrity disruption by cholesterol depletion can induce detachment-induced death. Hypoxia inducible factor-1 (HIF-1) α stabilized hypoxia transactivates numerous genes required for adaptation to hypoxia. It also induced non-hypoxic stimuli contributes survival. Because inhibits synthesis HIF-1α plays role...
To investigate school performance of childhood cancer survivors focusing on the child's functioning, including peer relationships, attendance, and academic achievement. We studied 241 children from 15 institutions in Korea between 2015 2016. The self-reported paper-and-pencil questionnaires were used. Approximately 22% suffered lack friends. Bullying was reported by 30% survivors. Survivors who returned to primary a higher incidence bullying compared with middle or high (P = 0.03)....
We report the outcome of 236 pediatric umbilical cord blood transplantations (UCBT) performed in Korea. Given that sources grafts were mostly unrelated donors (n = 226; 95.8%), only results UCBT included for all statistics. The most frequent primary disease was acute leukemia 167). In total, 91.7% recipients seropositive cytomegalovirus (CMV). median doses nucleated cells and CD34+ 4.84 × 10(7)/kg 2.00 10(5)/kg, respectively. times to neutrophil (>0.5 10(9)/L) platelet recovery (>20 18 45...
ABSTRACT Background Efficacy of gemcitabine and docetaxel (GEM + DOC) chemotherapy in patients with recurrent or refractory osteosarcoma was evaluated. Methods Data 53 from 9 institutions, who received GEM (675 900 mg/m 2 on days 1 8) DOC (100 day 8), were retrospectively reviewed. Results administered as adjuvant (n = 25) palliative 28). Patients a median 3 courses (range, 1−10 courses). Objective response rate (CR PR, where CR is complete PR partial response) disease control (CR+ SD, SD...
Abstract Background: We investigated the epidemiologic characteristics of childhood brain tumors (CBT) in Korea, and compared our findings with those from United States. Methods: searched Korea National Cancer Incidence Database Central Registry (KCCR) 2005 to 2014, which included all Korean patients CBT aged 0 19 years at diagnosis. The age-standardized incidence rates (ASR) 5-year relative survival rate (RSR) were determined. Brain Tumor States (CBTRUS) classification definitions applied...
Background Second malignant neoplasm is one of the most devastating late effects childhood cancers. This study aimed to evaluate incidence and survival outcomes patients developing second neoplasms (SMNs) after surviving cancer in Korea. Methods Medical data diagnosed between 1993 2012 were obtained from Korea Central Cancer Registry. The risk SMNs was calculated using standardized ratio (SIR), excess absolute (EAR), cumulative risk. Kaplan-Meier curves estimated, stratified by SMN status....
The efficacy and toxicity of high-dose chemotherapy autologous stem cell transplantation (HDCT/ASCT) were investigated for improving the outcomes patients with relapsed medulloblastoma.A total 15 medulloblastoma enrolled in KSPNO-S-053 study from May 2005 to 2007.All received approximately 4 cycles salvage after relapse.Thirteen underwent HDCT/ASCT; CTE CM regimen employed first HDCT (HDCT1) second (HDCT2), respectively, 7 HDCT2.One transplant related mortality (TRM) due veno-occlusive...
PurposeThis study investigated the incidence and relative survival rates (RSRs) for cancers among adolescents young adults (AYAs) aged 15-39 years between 1993 2016 in KoreaMaterials MethodsData from Korea Central Cancer Registry were used to calculate percent distributions, age-specific rates, age-standardized (ASRs) per million, annual changes (APCs), average APCs, RSRs diagnosed AYAs.Results ASR of all AYAs was 654.5 million. The largest group carcinomas (almost 80%). Crude increased with...
This retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors childhood cancer from multiple institutions Korea.A total 102 patients 11 who developed SMN after treatment between 1998 2011 were retrospectively enrolled.The most common primary (PMNs) central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia 16), non-Hodgkin lymphoma 13), osteosarcoma 12).The SMNs therapy-related myeloid (t-MNs;...
Activated phosphoinositide 3-kinase δ syndrome (APDS)1 is caused by gain-of-function mutations in PIK3CD, which encodes the catalytic p110δ subunit of 3 kinase. We describe three patients with APDS1, first thereof Korea. Therein, we investigated clinical manifestations APDS1 and collected data on efficacy safety profile sirolimus, a mammalian target rapamycin inhibitor pathway-specific targeted medicine. The same heterozygous PIK3CD mutation was detected all (E1021K). After genetic...
Background: Pleuropulmonary blastoma (PPB) is a rare and aggressive intrathoracic neoplasm that associated with other dysplastic or neoplastic conditions. The prognosis, especially of type II (cystic solid) III (solid) PPB, poor. High-dose chemotherapy (HDC) hematopoietic stem cell transplantation (HSCT) have been attempted to improve survival rates. We report the development follicular thyroid carcinoma in girl who was treated at young age for PPB. Summary: A 23-month-old evaluated clinical...
Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver cancer affecting adolescents and young adults without any pre existing disease. Hyperammonemic encephalopathy (HAE) serious paraneoplastic syndrome, several cases of HAE have been reported in patients with FLHCC. This condition rare; hence, there are currently no management guidelines for cancer-related HAE. Herein, we report case an 18-year-old man advanced FLHCC who developed during the first course chemotherapy consisting...
Cross-Cultural Adaptation of the Korean Version Minneapolis-Manchester Quality Life Instrument-Adolescent FormWe verified reliability and validity version Form (KMMQL-AF) among childhood cancer survivors.A total 107 patients undergoing treatment 98 survivors who completed were recruited.To assess internal structure KMMQL-AF, we performed multi-trait scaling analyses exploratory factor analysis.Additionally, compared each domains KMMQL-AF with those Karnofsky Performance Status Scale Revised...
For children and adolescents with cancer, going back to school is a key milestone in returning "normal life."To identify the support vital for successful transition, we evaluated parents' needs challenges they face when their return school.This multi-institutional study was conducted by Korean Society of Pediatric Hematology Oncology. The written survey comprised 24 questions completed 210 parents without an interviewer.Most (165 206) reported that experienced difficulties physical status...
Background The impact of HLA matching on outcomes unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) varies in different racial or ethnic groups. Since little is known about the such URD HSCT Korean children, we analyzed this issue. Methods We 142 patients who underwent at 4 medical centers. All patient pairs were fully typed for HLA-A, -B, -C, and -DR alleles. Results At a median follow-up 22 months, 3-year survival rates with 8, 7, ≤6 matched alleles 88.4%, 70.7%, 53.6%,...
An Infant with Prenatally Diagnosed Congenital Anaplastic Astrocytoma Who Remains Disease-Free after Proton TherapyThe authors present a rare of prenatally diagnosed congenital anaplastic astrocytoma.A 9-month-old boy had three recurrences despite two surgical resections and various chemotherapeutic regimens.He underwent the 3rd gross tumor removal at 11 months age, followed by proton therapy, now he remains disease-free for 3 yr without significant neurocognitive dysfunction.This is 1st...