A5065250343- Infection Control in Healthcare
- Thyroid Disorders and Treatments
- Metabolism and Genetic Disorders
- Ecology and Conservation Studies
- Sexual Differentiation and Disorders
- Childhood Cancer Survivors' Quality of Life
- Hormonal and reproductive studies
- Diverse Approaches in Healthcare and Education Studies
- Growth Hormone and Insulin-like Growth Factors
- RNA modifications and cancer
- Pharmacological Effects and Toxicity Studies
- Sarcoma Diagnosis and Treatment
- Testicular diseases and treatments
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Galectins and Cancer Biology
- Antimicrobial Resistance in Staphylococcus
- Pancreatic function and diabetes
- Congenital heart defects research
- Protein Tyrosine Phosphatases
- Medical Device Sterilization and Disinfection
- Forensic Toxicology and Drug Analysis
- Glycogen Storage Diseases and Myoclonus
- Genetic Syndromes and Imprinting
- Lymphoma Diagnosis and Treatment
Kangdong Sacred Heart Hospital
2019-2024
Hallym University
2019-2024
Gyeongsang National University
2024
National Cancer Center
2020-2023
CURE Childhood Cancer
2023
National Health Insurance Service Ilsan Hospital
2022
Inje University Haeundae Paik Hospital
2016-2019
Korea Forest Service
2017-2018
Korea National Arboretum
2017-2018
Cellular Therapeutics (United Kingdom)
2017
The epidemiology of osteosarcoma in adolescents and young adults (AYA) remains unclear. We aimed to assess compare the clinical features between AYA other age groups. retrieved cases diagnosed 1999 2017 from Korea Central Cancer Registry. compared survival trends characteristics comprised 43.3% (1309/3022) cases. Compared groups, male-to-female ratio was highest (1.61:1). proportion tumors located an extremity 80.3% AYA, which lower than children (92.5%) or pubertal (93.8%) but higher...
To compare the characteristics and risk factors for surgical site infections (SSIs) after total hip arthroplasty (THA) knee (TKA) in a nationwide survey, using shared case detection recording systems.Retrospective cohort study.Twenty-six hospitals participating Korean Nosocomial Infections Surveillance System (KONIS).From 2006 to 2009, all patients undergoing THA TKA KONIS were enrolled.SSI occurred 161 (2.35%) of 6,848 cases (3,422 THAs 3,426 TKAs). Pooled mean SSI rates 1.69% 2.82% TKA,...
<b><i>Background/Aims:</i></b> This study aimed to clarify the frequency, phenotypes, and molecular spectrum of <i>DUOX2</i>,<i> TPO</i>, <i>TSHR, </i>and <i>TG</i> mutations in patients with congenital hypothyroidism (CH) enlarged or normal-sized eutopic thyroid glands. <b><i>Methods:</i></b> The cohort included 43 subjects from 41 unrelated families who had CH Mutation analyses and<i>...
Mutations in the IGF1R gene result intrauterine growth retardation and postnatal failure.The objective of this study was to describe clinical features subjects with a mutation evaluate molecular functional characteristics novel mutation.Three children unexplained (birth weight <-1.5 SD score) persistent short stature (<-2.0 were included study.Auxological endocrinological profiles measured. All coding regions, including intron-exon boundaries gene, amplified via PCR directly sequenced. To...
Wide phenotypic and genotypic heterogeneities in Wilson's disease (WD) have been reported, hampering the study of their correlations. The goal this was to identify factors related these diversities.Clinical courses molecular genetic characteristics were analysed 237 unrelated Korean WD families. average follow-up period 8.2 ± 5.8 years.Presenting phenotypes classified as H1 (12.2%), H2 (42.4%), N1 (21.6%), N2 (0.4%), NX presymptomatic (22.4%) other modifying guidelines by Ferenci colleagues....
Subclinical hypothyroidism is defined as elevated thyroid-stimulating hormone (TSH) levels with the normal concentrations of thyroxine (T4) or free (fT4), and its clinical significance unclear. The purpose this study to investigate prevalence subclinical in children adolescents determine relationship between lipid profiles, insulin resistance thyroid hormones.A retrospective, cross-sectional was performed using data from a subset KNHANES VI. subjects whose ages were range 10-19 years...
The cork oak (Quercus suber L.) is a prevalent tree species in the Mediterranean climate zones of western Europe and north Africa with quite narrow geographical range distribution, as compared other evergreen such Quercus calliprinos (holly oak) ilex (holm oak). This offers ecological, economic social importance, including their biodiversity sustainable forest production these areas. increase mean annual temperature rainfall extremes during recent decades follows trends predicted by present...
Objective Pseudohypoparathyroidism (PHP) and pseudopseudohypoparathyroidism (PPHP) are rare disorders resulting from genetic epigenetic aberrations in the GNAS locus. Design Investigation of clinical characteristics molecular analysis PHP PPHP. Patients Fourteen subjects 13 unrelated families including with PPHP (n = 1), PHP-Ia 6) PHP-Ib 7) were enrolled. Measurements Clinical data, age at presentation, presenting symptom, auxological findings, family history, presence Albright hereditary...
<b><i>Background/Aims:</i></b> The objective of this study was to evaluate the efficacy recombinant human growth hormone (rhGH) therapy and influence genotype on response rhGH in children with Noonan syndrome (NS). <b><i>Methods:</i></b> 14 male 4 female subjects NS short stature, whose height <3rd percentile, were included. subcutaneously administered at a dose 66 µg/kg/day. Mutations <i>PTPN11</i> gene identified 10 (55.6%)....
To evaluate the risk factors for surgical site infection (SSI) after gastric surgery in patients Korea.A nationwide prospective multicenter study.Twenty university-affiliated hospitals Korea.The Korean Nosocomial Infections Surveillance System (KONIS), a Web-based system, was developed. Patients 20 from 2007 to 2009 were prospectively monitored SSI up 30 days surgery. Demographic data, hospital characteristics, and potential perioperative collected analyzed, using multivariate logistic...
This prospective study was conducted to investigate the feasibility of an early discontinuation thyroid hormone treatment in very-low-birth-weight (VLBW) infants with congenital hypothyroidism (CH).We enrolled VLBW between January 2011 and December 2012. The were divided into hypothyroid normal function groups according results a test. We performed off-therapy trial at 24 months age.Of 182 enrolled, 15 lost follow-up 167 finally enrolled. In total, (14.4%) assigned group treated hormone....
Maximizing accumulation of bone mass during childhood and adolescence is essential to attaining optimal peak mass. Childhood cancer survivors (CCS) have lower mineral density (BMD) than the general population. Chemotherapeutic agents including steroids radiotherapy can affect BMD. Cancer itself, hormonal insufficiency, a poor nutritional state, deficit physical activities or after treatment also influence BMD in CCS, resulting failure achieve appropriate Low lead osteoporosis adult life...
Abstract Steroid 21-hydroxylase deficiency is caused by inactivating mutations in the CYP21A2 gene. This paper reports on mutation spectrum and genotype-phenotype correlation of deficiency. 72 unrelated patients with congenital adrenal hyperplasia (CAH) were included. Molecular analysis was performed, via multiplex ligation-dependent probe amplification (MLPA) sequence-specific differenzial PCR CYP21A1P genes, using 4 pair-wise primers, followed sequencing entire Large gene deletions...
Objective The aim of this study was to compare clinical outcomes between patients with carbapenem-resistant Acinetobacter baumannii (CRAB) bacteremia treated colistin monotherapy and those plus meropenem. Methods We retrospectively evaluated data from 71 CRAB November 2006 February 2018. Predictors 14-day mortality were determined through logistic regression analysis. Results Our cohort included 40 (44.6 %) 31 (55.4 Overall tended be higher rather than combination therapy (47.5% vs 25.8%)....
Nonalcoholic fatty liver disease (NAFLD) is characterized by elevated hepatic enzymes, radiological feature of change, and steatosis with inflammation fibrosis in biopsy (1). Excluding infectious diseases, autoimmune drugs, α1-antirypsin deficiency, Wilson disease, NAFLD the preadolescent adolescent periods suggested to be mainly associated obesity due rapidly growing prevalence (1–3). Diverse inherited metabolic disorders including citrin deficiency can exhibit manifestations, mostly...
Copper-induced toxicity is important in the pathogenic process of Wilson's disease (WD). Using Long-Evans Cinnamon (LEC) rats, an animal model WD, study was undertaken to identify proteins involved WD and investigate their functional roles copper-induced hepatotoxicity. In early stages, expression levels mitochondrial matrix including agmatinase, isovaleryl coenzyme A dehydrogenase, cytochrome b5 were downregulated. As injuries progressed, along with subsequent apoptotic processes,...
Non-alcoholic fatty liver disease (NAFLD) is defined as chronic hepatic steatosis and becoming prevalent, along with the increasing trend for obesity in children adolescents. A non-invasive reliable tool needed to differentiate non-alcoholic steatohepatitis from simple steatosis. This study evaluated association between triglyceride glucose (TyG) index ultrasonographic indicator (US-FLI), possibility of using TyG prediction severity pediatric NAFLD.
In July 2010, we identified an outbreak of vancomycin-resistant enterococci (VRE) in our 26-bed neonatal intensive care unit.We performed epidemiological investigation after clinical cultures 2 neonates were positive for VRE.Identification, susceptibility testing, and molecular characterization performed.Cultures 3 surveillance stool samples inpatients 5 environmental VRE.All isolates as Enterococcus faecium containing the vanA gene.Two distinct clones by performing pulsed-field gel...