A5017676808- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Thyroid Disorders and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mitochondrial Function and Pathology
- Genomics and Rare Diseases
- Dermatology and Skin Diseases
- Growth Hormone and Insulin-like Growth Factors
- Viral gastroenteritis research and epidemiology
- Sexual Differentiation and Disorders
- Bacterial Infections and Vaccines
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Thyroid Cancer Diagnosis and Treatment
- Congenital heart defects research
- Allergic Rhinitis and Sensitization
- Viral Infections and Immunology Research
- Lipid metabolism and disorders
- Autoimmune Neurological Disorders and Treatments
- Neurological and metabolic disorders
- Systemic Lupus Erythematosus Research
- Hypothalamic control of reproductive hormones
- Asthma and respiratory diseases
- Birth, Development, and Health
- Ginseng Biological Effects and Applications
Dankook University
2011-2024
Dankook University Hospital
2013-2024
Ewha Womans University
2023
Wonkwang University
2016
University of Colorado Health
2006-2008
Seoul National University
2000-2005
New Generation University College
2005
OBJECTIVE—Autoimmune thyroid disease (AIT), celiac disease, and Addison’s are characterized by the presence of autoantibodies: peroxidase antibody (TPOAb) thyroglobulin (TGAb) in AIT, tissue transglutaminase (TTGAb) 21-hydroxylase (21-OHAb) disease. The objective this study was to define prevalence these autoantibodies clinical a population with type 1 diabetes. RESEARCH DESIGN AND METHODS—We screened 814 individuals diabetes for TPOAb, TGAb, TTGAb, 21-OHAb. Clinical defined chart review....
A significant percentage of nonautoimmune forms diabetes presents among children in all age groups, with a remarkable increase age.From October 1992 to 2004, total 859 less than 18 yr were newly diagnosed at the Barbara Davis Center for Childhood Diabetes and had blood samples obtained within 2 wk disease onset analysis antiislet autoantibodies glutamic acid decarboxylase-65, insulinoma-associated antigen-2, insulin, islet cell autoantibodies. The relationship autoantibody positivity human...
The aim of this study was to identify the risk factors for presence and severity diabetic ketoacidosis (DKA) at onset type 1 diabetes mellitus (T1DM) in Korean children adolescents. A retrospective chart review adolescents newly diagnosed with T1DM conducted seven secondary tertiary centers Korea. Eligible subjects were < 20 years age had records on or absence DKA time diagnosis. categorized as mild, moderate, severe. Data collected age, height, body weight, pubertal status, family history...
Objective: To compare the reliability of Greulich-Pyle (GP) method, Tanner-Whitehouse 3 (TW3) method and Korean standard bone age chart (KS) in evaluation prepubertal healthy children.Materials Methods: Left hand-wrist radiographs 212 children aged 7 to 12 years, obtained for traumatic injury emergency department, were analyzed by two observers.Bone was estimated using GP TW3 KS, calculated months.The correlation between measured each chronological child Pearson coefficient, scatterplot.The...
Abstract Previously, we explored the epidemic pattern and molecular characterization of enteroviruses isolated in Chungnam, Korea from 2005 to 2006. The present study extended these observations 2008 2009. In this study, showed similar seasonal prevalent summer fall age distribution previous investigation. most month was July: 42.9% 31.9% highest rate enterovirus-positive samples occurred children < 1-year-old-age. Enterovirus-positive were subjected sequence determination VP1 region,...
This study examined levels of blood lead and mercury, urinary cadmium, associated sociodemographic factors in 3–18 year-old Korean children adolescents. We used the nationally representative Environmental Health Survey Children Adolescents data for 2012–2014 identified 2388 adolescents aged years. The median 95th percentile exposure biomarker with 95% confidence intervals (CIs) were calculated. Multivariate regression analyses performed on log transformed adjusted age, sex, area, household...
Vitamin D status was evaluated in children with epilepsy taking anticonvulsants to determine the prevalence and risk factors of vitamin deficiency.This study designed as both a cross-sectional retrospective cohort study. A sum 198 who were diagnosed at Department Pediatrics Dankook University Hospital included. Their serum levels reviewed based on clinical information, analyzed using IBM SPSS ver. 20.0.One hundred twenty-four (62.6%) had deficiency. Two associated: winter spring season (odds...
Purpose Precocious puberty refers to the development of secondary sex characteristics before ages 8 and 9 years in girls boys, respectively. Central precocious (CPP) is caused by premature activation hypothalamus-pituitary-gonadal (HPG) axis causes thelarche age 8. A gonadotropin-releasing hormone (GnRH) stimulation test standard diagnostic modality for diagnosing CPP. However, cannot always be used screening because it expensive time-consuming. This study aimed find alternative reliable...
Objective Pseudohypoparathyroidism (PHP) and pseudopseudohypoparathyroidism (PPHP) are rare disorders resulting from genetic epigenetic aberrations in the GNAS locus. Design Investigation of clinical characteristics molecular analysis PHP PPHP. Patients Fourteen subjects 13 unrelated families including with PPHP (n = 1), PHP-Ia 6) PHP-Ib 7) were enrolled. Measurements Clinical data, age at presentation, presenting symptom, auxological findings, family history, presence Albright hereditary...
We studied the association of cytotoxic T lymphocyte antigen-4 gene (CTLA4) polymorphisms with development type 1 diabetes (T1D) in Korean children and adolescents. A total 176 subjects (92 females 84 males) childhood-onset T1D were studied. The A/G polymorphism at position 49 CTLA4 exon C/T -318 promoter analyzed by PCR-RFLP methods. genotype allele frequencies patients not different from those controls. These associated clinical characteristics or autoimmune thyroid disease patients....
Glycosylated hemoglobin (HbA1c) is often used as an indicator of glucose control. It usually reflects the average levels over two to three months, and correlated with development long-term diabetic complications. However, it can vary in cases hemoglobinopathy or altered red blood cell lifespan. The serum fructosamine reflect mean weeks. This study was designed determine clinical usefulness combined measurement HbA1c management childhood diabetes mellitus correlation between them.Clinical...
To investigate the effects of combined low-dose cyclosporine and prednisone (Cs/Pd) treatment on circulating CD56+ T cells in patients with Behçet's uveitis.Ten uveitis 10 healthy control subjects were prospectively recruited. The treated Cs/Pd for 2 months. Phenotypic functional changes assayed before after treatment. T-cell subsets determined by flow cytometric analysis monoclonal antibodies CD3, CD4, CD8, CD56, pan gammadelta TCR, Valpha24. absolute numbers lymphocyte calculated. Cytokine...
X-linked adrenal hypoplasia congenita is caused by the mutation of DAX-1 gene (dosage-sensitive sex reversal, critical region, on chromosome X, 1), and can occur as part a contiguous deletion syndrome in association with glycerol kinase (GK) deficiency, Duchenne muscular dystrophy interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) deficiency. It usually associated hypogonadotropic hypogonadism, although rare cases, it has been reported to normal puberty or even central precocious...
Congenital hypothyroidism (CH) is the most common endocrine disorder in neonates and infants with an incidence of one 2,000 to 4,000 newborns. Primary CH can be caused by thyroid dysgenesis dyshormonogenesis. due a TG gene mutation cause dyshormonogenesis characterized goitrous absent or low levels serum thyroglobulin (Tg). In present case, 15-day-old neonate was referred us elevated stimulating hormone detected during neonatal screening test. At age 34 months, extensive genetic testing...
There is controversy as to whether type 2 diabetes genetic susceptibility contributes 1 diabetes, and it not known what proportion of islet autoantibody-negative new onset subjects have risk alleles.We designed this study evaluate two diabetes-associated single nucleotide polymorphisms (SNPs) transcription factor 7-like (TCF7L2) gene are associated with the development vs. autoantibody-positive in young patients these SNPs specific clinical phenotypes.Autoantibody against glutamic acid...
Abstract Background Growth hormone (GH) treatment has become a common practice in Turner syndrome (TS). However, there are only few studies on the response to GH TS. The aim of this study is predict responsiveness and suggest prediction model height outcome Methods clinical parameters 105 TS patients registered LG Study (LGS) were retrospectively reviewed. prognostic factors for good responders identified, was investigated by random forest (RF) method, also, multiple regression models...
Purpose: Sensitization to allergens is considered as major mechanism of allergy and related the development allergic diseases. The objective this study was evaluate overall sensitization rates inhalant relationship between polysensitization prevalence diseases in children adolescents. Methods: A cross-sectional pilot 122 elementary school students, 114 middle 115 high students from Incheon Asan conducted by using International Study Asthma Allergies Childhood (ISSAC) questionnaire. skin...
Both the skin and neurologic system are derived from ectoderm during embryogenesis, thus patients with disorders may have accompanying dermatologic diseases. For example, seborrheic dermatitis is more frequently observed in Parkinsonism other disorders. To date, however, there has been limited review on diseases neurosurgical in-patients.The purpose of this study was to characterize dermatological problems encountered a neurosurgery unit compare these data previous reports in-patient...
Purpose: Most childhood diabetes mellitus (DM) is usually thought of as type 1 DM (T1DM), but the incidence 2 (T2DM) in increasing.Sometimes, it might not be easy to determine which a patient has and choose best treatment.The purpose this study evaluate usefulness autoantibody test clinical characteristics for specific diagnosis childhood.Methods: In study, we retrospectively reviewed medical records 42 patients who were diagnosed with followed at department pediatrics, Dankook University...