Although both type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) are associated with increased risk of cardiovascular (CVD), evidence is lacking as to whether the presence NAFLD confers an additional CVD in patients T2DM. We investigated associations between hepatic steatosis and/or fibrosis myocardial infarction (MI), stroke, heart failure (HF), mortality new-onset T2DM.Using Korean National Health Insurance dataset, we included 139,633 diagnosed T2DM who underwent...

Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic and independently affects the development cardiovascular (CV) disease. We investigated whether steatosis and/or fibrosis are associated with incident heart failure (iHF), hospitalized HF (hHF), mortality, CV death in both general population patients.We analyzed 778,739 individuals without 7445 patients pre-existing aged 40 to 80 years who underwent national health check-up from January 2009 December 2012. The...

Abstract Whether metabolic dysfunction-associated fatty liver disease (MAFLD) can replace nonalcoholic (NAFLD) is under debate. This study evaluated which definition better predicted incident chronic kidney (CKD). was a 5.3-year (range, 2.8–8.3) retrospective cohort of 21,713 adults who underwent at least two serial health examinations. Cox analyses were used to compare the risk CKD among non-fatty (FLD) without dysregulation (MD; reference), non-FLD with MD, MAFLD-only, NAFLD-only, or...

This study investigated the trends of insulin use among Korean patients with type 1 diabetes mellitus (T1DM) and 2 (T2DM). Changes in prescription antidiabetic medications T2DM taking therapy were evaluated.

We aimed to investigate the predictive values of plasma C-peptide levels and continuous glucose monitoring (CGM)-defined coefficient variation (CV) in risk prediction for hypoglycemia Korean people with diabetes normal impaired kidney function. analyzed data from 1,185 participants diagnosed type 1 2 who underwent blinded professional CGM between January 2009 May 2021 at outpatient clinics. explored correlations among CGM-defined CV, levels, time below range <70 54 mg/dL across different...

We sought to compare the diagnostic efficacy of a 72-hour wearable electrocardiography (ECG) patch monitoring with conventional 24-hour Holter for detection cardiogenic vertigo. conducted prospective multicenter study that recruited 47 patients suspected vertigo in four referral-based university hospitals between November 2019 and April 2022. Patients received simultaneous ambulatory ECG recordings using monitor. The primary outcome was rate arrhythmia events during entire wearing period....

Papillary thyroid carcinoma (PTC) can be classified into two distinct molecular subtypes, BRAF-like (BL) and RASlike (RL). However, the characteristics of each subtype according to clinicopathological factors have not yet been determined. We aimed investigate gene signatures tumor microenvironment factors, identify mechanism progression in BL-PTCs RL-PTCs.We analyzed RNA sequencing data corresponding information 503 patients with PTC from The Cancer Genome Atlas database. performed...

Non-alcoholic fatty liver disease (NAFLD) is a well-known risk factor for cardiovascular (CV) (CVD) and mortality. However, whether the progression or regression of NAFLD can increase decrease heart failure (HF) mortality has not been fully evaluated. We investigated association between changes in hepatic steatosis risks incident HF (iHF), hospitalization (hHF), including CV- liver-related mortality.Using database from National Health Insurance Service Korea January 2009 to December 2012, we...

Glycosylated hemoglobin (HbA1c) is often used as an indicator of glucose control. It usually reflects the average levels over two to three months, and correlated with development long-term diabetic complications. However, it can vary in cases hemoglobinopathy or altered red blood cell lifespan. The serum fructosamine reflect mean weeks. This study was designed determine clinical usefulness combined measurement HbA1c management childhood diabetes mellitus correlation between them.Clinical...

Abstract Aims/Introduction We estimated the hazards of cardiovascular diseases (CVDs) and early all‐cause mortality in Korean adults according to presence recently diagnosed type 2 diabetes (type for &lt;5 years) insulin use. Materials Methods used National Health Insurance Service–National Sample Cohort database (2002–2015) this longitudinal population‐based study. Among aged ≥40 years without baseline CVD, individuals or with were selected ( N = 363,919). The hazard ratios (HRs) myocardial...

The neutrophil–lymphocyte ratio (NLR) is a marker of systemic inflammation, and its elevation has recently been associated with poor survival in many solid cancers. Leukocyte lymphocyte reduction are response to radiotherapy (RT). This study aimed assess the prognostic value NLR before after RT for anaplastic thyroid carcinoma (ATC). retrospective analyzed 40 patients ATC who received available complete blood cell count data from November 1995 through May 2020 at Samsung Medical Center...

Abstract We aimed to compare the risk of incident diabetes according fatty liver disease (FLD) definition, focusing on comparison between those who met criteria for either metabolic dysfunction-associated (MAFLD) or nonalcoholic (NAFLD) but not other. This was a 5.0-year (interquartile range, 2.4–8.2) retrospective longitudinal cohort study 21,178 adults underwent at least two serial health checkup examinations. The presence hepatic steatosis determined by abdominal ultrasonography first...

Background: We aimed to identify the risk of incident depression according cumulative exposure a low-household income status in individuals with type 2 diabetes mellitus (T2DM).Methods: For this retrospective longitudinal population-based cohort study, we used Korean National Health Insurance Service data from 2002 2018. Risk was assessed (defined as Medical Aid registration) during previous 5 years among adults (aged ≥20 years) T2DM and without baseline who underwent health examinations...

Abstract Background We investigated the association between exercise habits before or after thyroidectomy and incident type 2 diabetes mellitus (T2DM) in patients with thyroid cancer. Methods An observational cohort study of 69,526 cancer who underwent for treatment 2010 2016 was performed using Korean National Health Information Database. Regular defined as mid-term vigorous at least 1 day a week based on self-reported questionnaire. Patients were divided into four groups according to...

The role of telomerase reverse transcriptase (TERT) promoter mutations as an independent poor prognostic factor in differentiated thyroid cancer (DTC) patients is well known, but there no system that combines the TERT mutation status with tumor-node-metastasis (TNM) stage to predict cancer-specific survival (CSS). A total 393 pathologically confirmed DTC after thyroidectomy were enrolled. After incorporating wild-type and mutant stages I, II, III/IV AJCC TNM 8th edition (TNM-8), we generated...

Using an investigational diet plan based on the Mediterranean and Dietary Approaches to Stop Hypertension comprised of substitute ingredients that mimic average East Asian diet, this study assessed glycemic benefits in comparison with a food exchange system-based established type 2 diabetes patients.This was 12-week, open-label randomized clinical trial carried out among 60 Korean adults having median body mass index 23.5 kg/m2 . Glycemic (group A) were compared those obtained either form...

Abstract We explored the association between cholesterol levels and dementia risk according to presence of diabetes statin use. In this population-based longitudinal cohort study, Korean National Health Insurance Service datasets (2002–2017) were used. Among individuals aged ≥ 40 years who underwent health examinations in 2009 (N = 6,883,494), hazard was evaluated levels. During a median 8.33 years, 263,185 cases detected. non-users with or without diabetes, hazards all-cause highest for...

This study evaluated the safety and efficacy of tubeless patch pump called EOPatch in patients with well-controlled type 1 diabetes mellitus (T1DM). 4-week, two-center, open-label, single-arm enrolled 10 adult diagnosed T1DM glycosylated hemoglobin less than 7.5%. The co-primary end points were usage time for one attachment number serious adverse events related to pump. secondary total amount insulin injected per changes glycemic parameters including continuous glucose monitoring data...

Abstract The objective of this study was to examine the dependence pressure level in wound area on height syringe needle from wound, gauge needle, and flow rate using Bernoulli equation. This control-volume analysis At a given fixed, area, which depended irrigation solution discharged tip calculated according equation definition rate. constant solution, velocity through decreased (7.80 → 0.80) with an increase diameter (18G 14G). inner increased reduction solution. As increased, increased....