A5023647772- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Thyroid Disorders and Treatments
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Growth Hormone and Insulin-like Growth Factors
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Cardiovascular Function and Risk Factors
- Vitamin D Research Studies
- Gout, Hyperuricemia, Uric Acid
- Body Composition Measurement Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- Digestive system and related health
- Heme Oxygenase-1 and Carbon Monoxide
- Thyroid Cancer Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Neuroendocrine Tumor Research Advances
- Neonatal Health and Biochemistry
- Diabetes Management and Research
- Bone health and osteoporosis research
- Heart rate and cardiovascular health
Samsung Medical Center
2015-2024
Sungkyunkwan University
2015-2024
Inha University Hospital
2018
Nonalcoholic fatty liver disease (NAFLD) has been associated with relative skeletal muscle mass in several cross-sectional studies. We explored the effects of and changes over time on development incident NAFLD or resolution baseline a large, longitudinal, population-based 7-year cohort study. included 12,624 subjects without 2943 who underwent health check-up examinations. A total 10,534 2631 were analysis year. Subjects defined as having by hepatic steatosis index, previously validated...
Skeletal muscle mass was negatively associated with metabolic syndrome prevalence in previous cross-sectional studies. The aim of this study to investigate the impact baseline skeletal and changes over time on development a large population-based 7-year cohort study. A total 14,830 11,639 individuals who underwent health examinations at Health Promotion Center Samsung Medical Center, Seoul, Korea were included analyses those from 1 year, respectively. estimated by bioelectrical impedance...
Thyroid hormones are important regulators of glucose homeostasis. However, the association between thyroid within reference range and type 2 diabetes mellitus (T2DM) remains unclear. The aim this study was to clarify incidence T2DM according baseline levels changes thyrotropin (TSH) (free thyroxine triiodothyronine) in euthyroid subjects.Among participants who consecutively underwent function tests 2006 2012 through a yearly health checkup program, 6235 subjects (3619 men 2616 women) without...
Abstract Context Low skeletal muscle mass often accompanies abdominal obesity in the aging process. Objective We aimed to investigate effect of reduced and its interaction with on incident type 2 diabetes. Methods This retrospective longitudinal study included 36 304 diabetes-free Koreans who underwent or more health checkups annually biannually. Appendicular was measured by bioelectrical impedance analysis presented as a index (SMI) adjusted for body weight. Presarcopenia defined an SMI...
Abstract Whether metabolic dysfunction-associated fatty liver disease (MAFLD) can replace nonalcoholic (NAFLD) is under debate. This study evaluated which definition better predicted incident chronic kidney (CKD). was a 5.3-year (range, 2.8–8.3) retrospective cohort of 21,713 adults who underwent at least two serial health examinations. Cox analyses were used to compare the risk CKD among non-fatty (FLD) without dysregulation (MD; reference), non-FLD with MD, MAFLD-only, NAFLD-only, or...
Abnormalities in glucose metabolism that precede the onset of type 2 diabetes (T2D) activate immune cells, leading to elevated inflammatory factors and chronic inflammation. However, no single-cell RNA sequencing (scRNA-seq) studies have characterized properties networks individual cells T2D. Here, we analyzed peripheral blood mononuclear (PBMCs) from non-diabetes T2D patients by scRNA-seq. We found CD14 monocytes were a pro-inflammatory state intermediate expressed more MHC class II genes....
Aim Serum albumin concentration is associated with both type 2 diabetes and metabolic syndrome (MetS). We sought to investigate whether baseline serum change in could be independent risk factors for prediabetes subjects without MetS. further examined the effect of on progression overt who developed prediabetes. Methods Among 10,792 participants MetS consecutively underwent yearly health check-ups over six years, 9,807 incident were enrolled this longitudinal retrospective study. The...
Current bioelectric impedance analysis (BIA) systems are often large, cumbersome devices which require strict electrode placement on the user, thus inhibiting mobile capabilities. In this work, we developed a handheld BIA device that measures from multiple frequencies (5 kHz~200 kHz) with four contact electrodes and evaluated against standard body composition systems: dual-energy X-ray absorptiometry (DXA) system (GE Lunar Prodigy, GE Healthcare, Buckinghamshire, UK) whole-body (InBody S10,...
Background It has not been determined whether changes in serum uric acid (SUA) level are associated with incident metabolic syndrome (MetS). The aim of the current study was to investigate relationship between SUA and development MetS a large number subjects. Methods In total, 13,057 subjects participating medical health check-up program without diagnosis at baseline were enrolled. Cox proportional hazards models used test independent association percent MetS. Results After adjustment for...
This study was conducted to investigate whether baseline lung function or change in is associated with the development of metabolic syndrome (MS) Koreans. We analyzed clinical and laboratory data from 3,768 Koreans aged 40-60 years who underwent medical check-ups over a six-year period between 2006 2012. calculated percent forced vital capacity (FVC) expiratory volume 1 s (FEV1) period. tested for an association during follow-up MS. The 533 subjects (14.1%) developed MS after follow-up. FVC...
Serum bilirubin level was negatively associated with the prevalence of metabolic syndrome (MetS) in previous cross-sectional studies. However, variance preceding development MetS has yet to be investigated. We aimed determine effect change concentration on risk incident healthy Korean adults.We conducted a retrospective longitudinal study subjects who had undergone at least four yearly health check-ups between 2006 and 2012. Of 24,185 total individuals received annual check-ups, 11,613...
ABSTRACT Aims/Introduction Several cross‐sectional studies have shown that delayed heart rate recovery (HRR) after exercise is associated with the development of metabolic syndrome (MetS). However, there has been a lack comprehensively designed longitudinal studies. Therefore, our aim was to evaluate association HRR following graded treadmill test (GTX) incident MetS. Materials and Methods This retrospective cohort study participants without MetS, diabetes, or cardiovascular diseases. The...
Background: Women are more likely to experience thyroid diseases than men. However, dysfunction risk in women undergoing the menopausal transition remains largely unknown. We explored prevalence of across stages. Methods: conducted a cross-sectional study 53,230 aged 40 years or older who underwent health screening between 2014 and 2018. Menopausal stages were categorized into 4 based on Stages Reproductive Aging Workshop +10 criteria. A multinomial logistic regression model was used...
Purpose: This study compared the diagnostic performance of quantitative ultrasonography (QUS) with that conventional (US) in assessing hepatic steatosis among individuals undergoing health screening using magnetic resonance imaging–derived proton density fat fraction (MRI-PDFF) as reference standard.Methods: single-center prospective enrolled 427 participants who underwent abdominal MRI and US. Measurements included attenuation coefficient tissue imaging (TAI) scatter-distribution (TSI). The...
Background Serum albumin and uric acid have been positively linked to metabolic syndrome (MetS). However, the association of MetS incidence with combination levels has not investigated. We explored risk incident in populations divided according these two parameters. Methods In this retrospective longitudinal study, 11,613 non-MetS participants were enrolled among 24,185 individuals who had undergone at least four annual check-ups between 2006 2012. The was analyzed groups categorized by...
Abstract We aimed to compare the risk of incident diabetes according fatty liver disease (FLD) definition, focusing on comparison between those who met criteria for either metabolic dysfunction-associated (MAFLD) or nonalcoholic (NAFLD) but not other. This was a 5.0-year (interquartile range, 2.4–8.2) retrospective longitudinal cohort study 21,178 adults underwent at least two serial health checkup examinations. The presence hepatic steatosis determined by abdominal ultrasonography first...
Abstract This study developed and validated multivariable quantitative ultrasound (QUS) model for diagnosing hepatic steatosis. Retrospective secondary analysis of prospectively collected QUS data was performed. Participants underwent examinations magnetic resonance imaging proton density fat fraction (MRI-PDFF; reference standard). A regression estimating determined using two parameters from one tertiary hospital (development set). Correlation between QUS-derived estimated fraction(USFF)...