Abstract Purpose To determine the relevance of cerebrospinal fluid (CSF)‐suppression for measurement diffusion anisotropy in well‐localized areas brain, particularly subcortical white matter (WM) within gyri and cortical gray (GM), young elderly subjects, to assess changes water diffusivity brain with normal aging. Materials Methods Quantitative measures 26 regions, including WM (i.e., gyri), GM, major deep WM, GM regions (21–25 years, N = 8) (61–74 10) volunteers, were assessed...

To examine the ability of three-dimensional micro-magnetic resonance (MR) imaging-based computational biomechanics to detect mechanical alterations in trabecular bone and cortical distal tibia incident renal transplant recipients 6 months after transplantation compare them with mineral density (BMD) outcomes.The study was approved by institutional review board complied HIPAA guidelines. Written informed consent obtained from all subjects. Micro-MR imaging tibial metaphysis performed within 2...

Purpose To quantify bulk bone water to test the hypothesis that concentration (BWC) is negatively correlated with mineral density (BMD) and positively age, propose suppression ratio (SR) (the of signal amplitude without long-T2 suppression) as a potentially stronger surrogate measure porosity, which evaluated ex vivo in vivo. Materials Methods Human subject studies were conducted compliance institutional review board HIPAA regulations. Healthy men women (n = 72; age range, 20–80 years)...

Establishing time of onset is important in acute stroke management. Current imaging modalities do not allow determination time. Although correlations between sodium magnetic resonance signal intensity within ischemic lesions and have been shown animal models, the relation to has established human stroke. Utilizing high-quality images, we tested hypothesis that increases with from symptom stroke.Twenty-one patients (63 +/- 15 years old) were scanned 4 104 hours after onset. Follow-up images...

To assess the relationship between sodium signal intensity changes and oligemia, measured with perfusion-weighted imaging (PWI), in ischemic stroke patients.Nine patients (55 ± 13 years), four follow-up scans, underwent proton 4-32 hours after symptom onset. Relative was calculated as ratio of intensities core (identified hypertintense lesions on diffusion-weighted [DWI]) or putative penumbra (PWI-DWI mismatch) to contralateral homologous regions.Sodium increases were not correlated severity...

Bone is a composite material consisting of mineral and hydrated collagen fractions. MRI bone challenging because extremely short transverse relaxation times, but solid‐state imaging sequences exist that can acquire the short‐lived signal from tissue. Previous work to quantify density via used powerful experimental scanners. This seeks establish feasibility MRI‐based measurement on clinical scanners collagen‐bound water densities, latter as surrogate matrix density, examine associations these...

Current bioelectric impedance analysis (BIA) systems are often large, cumbersome devices which require strict electrode placement on the user, thus inhibiting mobile capabilities. In this work, we developed a handheld BIA device that measures from multiple frequencies (5 kHz~200 kHz) with four contact electrodes and evaluated against standard body composition systems: dual-energy X-ray absorptiometry (DXA) system (GE Lunar Prodigy, GE Healthcare, Buckinghamshire, UK) whole-body (InBody S10,...

Severe deficiencies of testosterone (T) and GH are associated with low bone mineral density (BMD) increased fracture risk. Replacement T in hypogonadal men improves several parameters. GH-deficient BMD. Our objective was to determine whether treatment together the structural mechanical parameters more than alone hypopituitarism. This randomized, prospective, 2-year study included 32 severe due panhypopituitarism. Subjects were randomized receive (n = 15) or 17) for 2 years. We evaluated...

Wearable sensors afford convenience in daily health monitoring, though many challenges the development of such systems need to be overcome. Here, we present a low-power, multimodal analog front end (AFE) for wearable monitoring based on novel system architecture and very large scale integration circuit design methods. The AFE integrated was designed with standard 65-nm CMOS technology. Three sensor AFEs, bio-potential, photoplethysmography (PPG), bioelectrical impedance analyser (BIA) were...

Diffusion anisotropy changes in stroke lesions less than 24 h after onset have been reported to be elevated, decreased, or both. To address these mixed findings, we sought characterize temporal of diffusion by analyzing anatomically distinct ischemic white matter (WM) regions at 3 time phases within the first 34 26 patients (2 5 h, N = 7; 7 14 11; 18 8). Mean diffusivity (Trace/3 apparent coefficient (ADC)), fractional (FA), and T2-weighted signal intensity were measured for major...

Bone strength is the key factor impacting fracture risk. Assessment of bone from high-resolution (HR) images have largely relied on linear micro-finite element analysis (μFEA) even though failure always occurs beyond yield point, which outside regime. Nonlinear μFEA may therefore be more informative in predicting behavior. However, existing nonlinear models applied to trabecular (TB) been confined micro-computed tomography (μCT) and, recently, HR peripheral quantitative computed (HR-pQCT)...

Intoxication by the organophosphate compound soman causes prolonged seizures that lead to neuropathology in brain. This MRI-based study describes temporal and spatial evolution of brain pathology follows soman-induced convulsions. We observed significant decreases apparent diffusion coefficients (ADC; 23% below control) hippocampus thalamus 12 h after treatment. The ADC then returned near normal values all regions at 24 but declined again during next 7 days. These data suggest initial...

To assess the performance of a 3D fast spin echo (FSE) pulse sequence utilizing out-of-slab cancellation through phase alternation and micro-magnetic resonance imaging (μMRI)-based virtual bone biopsy processing methods to probe serial reproducibility sensitivity structural mechanical parameters distal tibia at 7.0T.The five healthy subjects was imaged three timepoints with FSE 137 × 410 μm(3) voxel size. Follow-up images were retrospectively registered baseline images. Coefficients...

Diffusion-weighted imaging (DWI) identifies acute cerebral ischemia and DWI lesions are thought to indicate irreversibly damaged areas. However, new evidence suggests that may be reversible, especially with reperfusion. We present a patient who showed substantial reversal of her lesion following partial aortic occlusion Neuroflo™, novel dual balloon catheter (Neuroflo™, CoAxia, MN).Case report/literature review.A 48-year-old woman presented left-sided weakness demonstrated an in the right...

The standard in noninvasive blood pressure (BP) measurement is an inflatable cuff device based on the oscillometric method, which poses several practical challenges for continuous BP monitoring. Here, we present a novel ultra-wide band RF Doppler radar sensor next-generation mobile interface purpose of characterizing fluid flow speeds, and ultimately measuring cuffless human wrist. system takes advantage 7.1~10.5 GHz signals can reduce transceiver complexity power consumption overhead....

Abstract The relationship between fabric (a measure of structural anisotropy) and elastic properties trabecular bone was examined by invoking morphology homogenization theory on the basis micromagnetic resonance images from distal tibia in specimens ( N = 30) human subjects 16) acquired at a 160 × μm 3 voxel size. tensor mapped 7.5 mm cubic subvolumes three‐dimensional mean‐intercept‐length method. Elastic constants (three Young's three shear moduli) were derived linear microfinite element...

Although electrocardiography (ECG) monitoring systems have been available in the form of wearable patches for better part two decades, they are limited their ability to be utilized as inexpensive, yet vital short-term measurement devices that (truly) completely disposable. Advancing current practices soft conformable electronics, we present a Bluetooth-enabled, fully disposable single-lead ECG patch comprising inkjet printed Ag-AgCl electrodes and components integrated on single, flexible...

Wearable sensors afford convenience in daily health monitoring, though many challenges the development of such systems need to be overcome. Here, we present a low power, multimodal analog front-end (AFE) for wearable monitoring sensors. The AFE integrated circuit was designed and fabricated with standard 65 nm CMOS technology. Three sensor AFEs, bio-potential, photoplethysmography (PPG) bioelectrical impedance analysis (BIA), were on same die an area 2.5×2.5 mm2. power consumption is within...

Quantification of energy storage is essential in understanding balance and can be determined by bioelectrical impedance analysis (BIA). Here, we have developed a smartphone form factor multi-frequency BIA device that incorporates an analog front end for body composition measurements. The was compared against reference gel-electrode based system clinical trial 311 subjects predicting equations calibrating the index to data from dual X-ray absorptiometry (DXA). Strong correlations were...

Sleep-wake cycle activity monitoring or actigraphy is an essential tool in sleep research and medicine. In this paper, we investigated the clinical validation of a novel wrist actigraph mobile health device incorporating proportional integration mode (PIM) algorithm. Thirty-three subjects underwent polysomnography (PSG) exams concurrent during overnight study evaluating comparing efficiency between two modalities. The mean difference methods was 2.0%. We observed moderately favorable...