A5091900101- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Lymphoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Viral-associated cancers and disorders
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Salivary Gland Tumors Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Urological Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Urologic and reproductive health conditions
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
National Cancer Center
2015-2025
LG (South Korea)
2018-2022
Prostate Cancer UK
2011-2016
Institut für Internationale Kommunikation
2015
Minami Kyushu Junior College
2015
The University of Texas MD Anderson Cancer Center
2008
The University of Texas Southwestern Medical Center
2008
Children's Cancer Center
2008
National Cancer Center
2005
Kangwon National University
1999-2004
Although NKT cells has been known to exert protective roles in the development of autoimmune diseases, functional downstream events antibody-induced joint inflammation remain unknown. Thus, we explored arthritis using K/BxN serum transfer model. cell–deficient mice were resistant arthritis, and wild-type administrated with α-galactosyl ceramide, a potent cell activator, aggravated arthritis. In CD1d−/− mice, transforming growth factor (TGF)-β1 was found be elevated tissues, blockade TGF-β1...
We evaluated the clinical significance of lymphovascular invasion in transurethral resection bladder tumor specimens patients with newly diagnosed T1 urothelial carcinoma bladder.Enrolled study were 118 who underwent between 2001 and 2007. Patient records retrieved from a prospectively maintained cancer database. correlation other clinicopathological features, impact on disease recurrence, progression metastasis.Lymphovascular was histologically confirmed 33 (28.0%). While correlated grade...
Abstract Large flexible organic light‐emitting diode (OLED) display provides various electronic applications such as curved, bendable, rollable, and commercial display, because of its thinness, light weight, design freedom. In this work, the process flow key technologies to fabricate world's first large size 77‐inch transparent OLED are introduced. “White on TFT + color filter” method is used aforementioned display. On both thin‐film transistor filter substrates, polyimide (PI) was plastic...
Objective To assess the prognostic roles of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue biomarkers in localized renal cell carcinoma (RCC). Methods Patients who underwent a nephrectomy during 1992–2015 had primary specimen their kidney tumor were included. The nine immunohistochemically stained on microarrays RCC, semi-quantitative H-score, including intensity score, was used to grade sample. Cox proportional hazards model evaluate markers significant for overall...
Abstract Background NUT carcinoma is a rare aggressive disease caused by BRD4/3-NUT fusion, and C-MYC upregulation plays key role in the pathogenesis. Here, we report on clinicopathological characteristics of Korean patients with vitro efficacy MYC-targeting agents against patient-derived cell lines. Materials Methods Thirteen were evaluated for p53, C-MYC, epidermal growth factor receptor (EGFR), HER2, programmed death ligand 1 (PD-L1) immunohistochemistry. The half maximal inhibitory...
Objectives The aim of this study was to investigate the expression two commonly altered genes ERG and PTEN in prostate cancer (PC) evaluate their prognostic significance. Despite conflicting published results, TMPRSS2-ERG gene fusion loss are generally considered unfavorable markers for PC progression. Materials Methods Of 762 prostatic adenocarcinoma specimens obtained from radical prostatectomy, 613 without neoadjuvant hormone therapy were included tissue microarrays quantitatively...
To protect brittle layers in organic photovoltaic devices, the mechanical neutral plane strategy can be adopted through placing functional materials close to where stress and strain are zero during bending. However, previous research has been significantly limited location number of using a single plane. In this study, multiple planes generated low elastic modulus adhesives controlled quantitative analyses order at various locations. Moreover, protection locations under both concave convex...
Chromosome missegregation and the resulting aneuploidy is a common change in neoplasia. The Aurora kinase A (AURKA) gene, which encodes key regulator of mitosis, frequently amplified and/or overexpressed cancer cells, level AURKA amplification associated with aneuploidy. We examined whether gene biomarker for detection bladder cancer.The effect ectopic expression using an adenoviral vector simian virus 40-immortalized urothelial cells (SV-HUC) on centrosome multiplication chromosome copy...
No AccessJournal of UrologyInvestigative Urology1 Feb 2014Intravesical Instillation c-MYC Inhibitor KSI-3716 Suppresses Orthotopic Bladder Tumor Growth Kyung-Chae Jeong, Kyung-Tae Kim, Hye-Hyun Seo, Seung-Pil Shin, Kyung-Ohk Ahn, Min-Ju Ji, Weon Seo Park, In-Hoo Sang-Jin Lee, and Ho Kyung JeongKyung-Chae Jeong Biomolecular Function Research Branch, National Cancer Center, Gyeonggi-do, Republic Korea , KimKyung-Tae Kim Molecular Epidemiology SeoHye-Hyun Genitourinary ShinSeung-Pil Shin...
Recent findings in molecular pathology suggest that genetic translocation and/oroverexpression of oncoproteins is important salivary gland tumorigenesis and diagnosis. Weinvestigated PLAG1, SOX10, Myb protein expression various neoplasm tissues.A total 113 cases surgically resected neoplasms at the NationalCancer Center from January 2007 to March 2017 were identified. Immunohistochemical stainingof tissue samples was performed using microarrays.Among cases, 82 (72.6%) benign 31 (27.4%)...
CD99 is a cell surface molecule involved in the aggregation of lymphocytes and apoptosis immature cortical thymocytes. Despite its high level expression on thymocytes, functional roles this during thymic selection are only now being elucidated. Examination effects engagement kinetics TCR MHC class I II molecules, which primarily positive selection, revealed marked up-regulation these proteins This increase was result accelerated mobilization molecules stored cytosolic compartments to plasma...
Abstract Background Non-Hodgkin lymphoma (NHL) is a hematologic malignancy for which good diagnostic markers are lacking. Despite continued improvement in our understanding of NHL, efforts to identify have yielded dismal results. Here, we translated low-mass-ion information urine samples from patients with NHL into marker. Methods To minimize experimental error, tested variable parameters before MALDI-TOF analysis low-mass ions urine. Urine 30 controls and was analyzed as training set...
Objectives To determine the potential association between HPV infection and squamous cell component of urothelial carcinoma (UC) bladder to validate p16 overexpression as a surrogate marker for in these cancers among Koreans. Methods We analyzed presence using an HPV-DNA chip expression immunohistochemistry 47 subjects July 2001 March 2011. The study group (n = 35) included patients with differentiation UC bladder. control 12) metaplasia Results Baseline characteristics groups were similar....
Purpose This descriptive study assessed the current trends in incidence of urological cancers and patient survival Korea. Materials Methods In this nationwide retrospective observational based on data from Korea National Cancer Incidence Database (KNCIDB), analyzed age-standardized rates (ASRs) annual percentage changes (APCs) kidney, bladder, prostate, testicular, penile as well cancer renal pelvis ureter between 1999 2012. The relative (RSRs) were calculated for patients diagnosed 1993...
PurposeThe treatment outcome of brentuximab vedotin (BV) has not been related with CD30 expression in previous studies enrolling patients a wide range level. Thus, this study explored the efficacy BV high-CD30–expressing non-Hodgkin lymphoma (NHL) most likely to benefit.Materials and MethodsThis phase II (Clinicaltrials.gov: NCT02280785) enrolled relapsed or refractory NHL, administered intravenously at 1.8 mg/kg every 3 weeks. The primary endpoint was > 40% disease control rate,...
Abstract The down-regulation of surface expression MHC class I molecules has recently been reported in the CD99-deficient lymphoblastoid B cell line displaying characteristics Hodgkin’s and Reed-Sternberg phenotype. Here, we demonstrate that reduction on is primarily due to a defect transport from Golgi complex plasma membrane. Loss CD99 did not affect steady-state levels mRNA protein molecules. In addition, assembly endoplasmic reticulum cis-Golgi occurred normally cells, no difference was...
Abstract Background Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC) exhibits distinct patterns worldwide, but its prevalence has not been extensively evaluated in Korea. The E7 oncogene‐mediated carcinogenesis and meaning are yet to be uncovered for SCCs. Methods In a Korean SCC cohort, epidemiological indicators, HPV, G1 cycle marker expressions were correlated with survival. Results Among 93 surgically treated patients SCCs, 49.5% HPV+, which significantly...
$('.header-date').hide();$('#titleAuthors').hide(); $('#abstractHeader').hide(); Ho Kyung Seo 1 , Kyung-Ohk Ahn 2 Nae-Rae Jung 3 Ji-Sun Shin Weon Park Kang Hyun Lee Sang-Jin and Kyung-Chae Jeong Center for Prostate Cancer, Hospital, National Cancer Center, Goyang, Gyeonggi-do, Korea Biomolecular Function Research Branch, Institute, Genitourinary Correspondence: Jeong, e-mail: jeongkc@ncc.re.kr Lee, leesj@ncc.re.kr Key words: Bladder cancer, c-Myc, inhibitor, gemcitabine, gemcitabine...