A5100442162- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Thyroid Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Head and Neck Anomalies
- Wound Healing and Treatments
- CAR-T cell therapy research
- Cancer and Skin Lesions
- Surgical Sutures and Adhesives
- Hemostasis and retained surgical items
- Thyroid and Parathyroid Surgery
- Immune Response and Inflammation
- Salivary Gland Tumors Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Bone Tumor Diagnosis and Treatments
- Immune cells in cancer
- Pituitary Gland Disorders and Treatments
- Genomics and Chromatin Dynamics
- Periodontal Regeneration and Treatments
- Body Contouring and Surgery
- Tendon Structure and Treatment
- Hedgehog Signaling Pathway Studies
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Dermatologic Treatments and Research
University of Ulsan
2022-2025
Asan Medical Center
2022-2025
Ulsan College
2022-2025
Seoul National University Bundang Hospital
2011-2024
Yale University
2024
Seoul National University
2003-2023
Sahmyook University
2022
Korea University
2022
Shaikh Khalifa Medical City
2019
Ewha Womans University
2017
There are still some controversies regarding the cutoff value and influential factors of thyroglobulin (Tg) concentration in washout fluid from fine-needle aspiration (FNA) biopsy (FNA-Tg) on cervical lymph nodes (LNs) patients with papillary thyroid cancer (PTC). Our aims were to validate FNA-Tg diagnosing malignant LNs a large scale investigate that could result discrepancy between final diagnosis FNA-Tg. We conducted retrospective cohort study based hospital records 528 cases measurement...
Summary Background Atypia or follicular lesions of undetermined significance ( AUS / FLUS ) is a broad cytological category in the B ethesda system for classifying thyroid cytology. This study investigated diagnostic accuracy ultrasound US analysis nodules with . Patients and Methods Of 5062 subjects subjected to fine‐needle aspiration cytology FNAC s) at our institution from January 2010 through May 2012, 383 met Bethesda criteria After excluding who had history cancer, only underwent...
BACKGROUND “Atypia of undetermined significance” (AUS) in the Bethesda System for Reporting Thyroid Cytopathology is a heterogeneous category cases that cannot be easily classified into benign, suspicious, or malignant. This study evaluated whether cytomorphology‐based subcategorization could better predict malignancy risk designated as AUS, and how subcategories correlated with BRAF mutation status thyroid fine‐needle aspirates (FNA). METHODS Of 3589 FNA diagnosed at authors' institution...
Background: In augmentation rhinoplasty, delayed morphologic changes are often observed with silicone implants, despite them being known as a safe implant material. The purpose of this study was to identify the cause and time course shape through long-term evaluation inserted implants their surrounding nasal soft tissues after removal at revision rhinoplasty operations. Methods: Two hundred twenty-one removed during were studied. period insertion ranged from 1 month 25 years, an average 6...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown causes. Three proteins (mammalian target rapamycin, mTOR; zinc finger E-box-binding homeobox 1, ZEB1; Rho-associated, coiled-coil containing protein kinase ROCK1) may be related to fibrosis. However, they have not been assessed in human We the clinical significance mTOR, ZEB1, and ROCK1 expression usual interstitial pneumonia (UIP) pattern. Methods The was evaluated by immunohistochemical staining 30...
Background Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhiza radix, has been reported to have antioxidant effects. We examined the effects of LAB on prevention diabetic retinopathy in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, animal model type 2 diabetes. Methods and Findings (10 or 20 mg/kg) normal saline were given orally once daily 24-week-old male OLETF rats for 52 weeks. At end treatment, fundoscopic findings, vascular endothelial growth factor...
Natural killer (NK) cells are key effectors in cancer immunosurveillance, eliminating a broad spectrum of without major histocompatibility complex (MHC) specificity and graft-versus-host diseases (GvHD) risk. The use allogeneic NK cell therapies from healthy donors has demonstrated favorable clinical efficacies treating diverse cancers, particularly hematologic malignancies, but it requires cytokines such as IL-2 to primarily support persistence expansion. However, the role regulation...
Chimeric antigen receptors (CARs) are synthetic that reprogram the target specificity and functions of CAR-expressing effector cells. The design CAR constructs typically includes an extracellular antigen-binding moiety, hinge (H), transmembrane (TM), intracellular signaling domains. Conventional primarily designed for T cells but have been directly adopted other cells, including natural killer (NK) without tailored optimization. Given benefits CAR-NK over CAR-T in terms safety, off-the-shelf...
The decline in eel resources, coupled with the challenges of morphological identification and rise illegal trade, highlights urgent need for accurate species techniques. To address this, a multiplex PCR assay was developed, targeting mitochondrial Cytochrome b gene. Species-specific primers were designed their efficacy validated through single PCR. conditions then optimized to enable simultaneous amplification five major species. This exhibited high accuracy, specificity, sensitivity,...
AIM:To investigate the roles of lymphocytes in development dextran sulfate sodium-induced colitis. METHODS:Using various doses sodium (DSS), we induced colitis wild-type B6 control and Rag-1 knockout (H-2 b haplotype) mice, evaluated terms symptomatic histologic parameters, such as weight loss, survival, severity diarrhea, shortage colon length histological changes.Symptomatic parameters were checked daily changes scored. RESULTS:Although mice treated with high dose (5%) DSS was comparable...
Induction of antigen-specific T cell tolerance would aid treatment diverse immunological disorders and help prevent allograft rejection graft versus host disease. In this study, we establish a method inducing in situ diabetic humanized mice Rhesus monkeys receiving porcine islet xenografts. Antigen-specific is induced by administration an antibody ligating particular epitope on ICAM-1 (intercellular adhesion molecule 1). Antibody-mediated ligation dendritic cells (DCs) led to the arrest DCs...
Background: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has standardized the reporting of thyroid cytology specimens.The objective current study was to evaluate nationwide usage TBSRTC and assess malignancy rates in each category Korea.Methods: Questionnaire surveys were used data collection on fine needle aspiration (FNA) nodules at 74 institutes 2012.The incidences follow-up diagnosed from January December, 2011, institute also collected analyzed.Results: Sixty out...
Indoleamine 2,3-dioxygenase (IDO) is overexpressed in many different types of tumor and associated with activation FOXP3+ regulatory T cells (Treg cells) downregulation cytotoxic cellular immunity the microenvironment. It has been suggested that IDO inhibitors can be utilized as an effective therapeutic agent against human cancers. However, expression its association tumor-infiltrating lymphocytes (TILs) remain unclear papillary thyroid microcarcinoma (PTMC).Immunohistochemical staining for...
Objectives:Nucleic acid amplification tests on formalin-fixed, paraffin-embedded (FFPE) tissue specimens enable Mycobacterium tuberculosis complex (MTB) detection and rapid diagnosis in the absence of microbiologic culture tests. We aimed to evaluate efficacy different polymerase chain reaction (PCR) methods for detecting species FFPE tissues.
Aims Few clinicopathological parameters have been identified as independent predictive factors for lymph node metastasis. This study evaluated the ability of three histological characteristics PTC in metastases: hobnail features, loss cohesiveness/polarity ( LOCP ) and micropapillary structures. Methods results Tissue specimens from 153 patients with histologically confirmed including 112 cases papillary thyroid microcarcinoma PTMC were enrolled this study. Three (hobnail structures) several...