A5023583765- Hepatocellular Carcinoma Treatment and Prognosis
- Acupuncture Treatment Research Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Bioinformatics and Genomic Networks
- Pancreatic and Hepatic Oncology Research
- Multiple and Secondary Primary Cancers
- Healthcare and Venom Research
- Pelvic floor disorders treatments
- Musculoskeletal pain and rehabilitation
- Colorectal Cancer Screening and Detection
- Vestibular and auditory disorders
- Urinary Bladder and Prostate Research
- Complementary and Alternative Medicine Studies
- Renal cell carcinoma treatment
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- Computational Drug Discovery Methods
- Blood disorders and treatments
- Aortic aneurysm repair treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Traditional Chinese Medicine Studies
- Renal and Vascular Pathologies
Kyung Hee University
2015-2019
Statistics Korea
2010-2018
National Cancer Center
2013-2016
Korea University
2010-2015
Kyung Hee University Medical Center
2015
Korea University Medical Center
2014-2015
Purpose Tumor regression grade (TRG) is predictive of therapeutic response in rectal cancer patients after chemoradiotherapy (CRT) followed by curative resection. However, various TRG systems have been suggested, with subjective categorization, resulting interobserver variability. This study compared the prognostic validity four different order to identify most ideal system. Materials and Methods included 933 who underwent preoperative CRT Primary tumors alone were graded according American...
Objectives The aim of this study was to investigate the expression two commonly altered genes ERG and PTEN in prostate cancer (PC) evaluate their prognostic significance. Despite conflicting published results, TMPRSS2-ERG gene fusion loss are generally considered unfavorable markers for PC progression. Materials Methods Of 762 prostatic adenocarcinoma specimens obtained from radical prostatectomy, 613 without neoadjuvant hormone therapy were included tissue microarrays quantitatively...
Gene expression data can be associated with various clinical outcomes. In particular, these of importance in discovering survival-associated genes for medical applications. As alternatives to traditional statistical methods, sophisticated methods and software programs have been developed overcome the high-dimensional difficulty microarray data. Nevertheless, new algorithms are needed include practical functions such as discovery multiple sets incorporation risk factors, use R environment...
To evaluate the clinical outcomes of patients with hepatocellular carcinoma (HCC) and compare findings that a previous cohort.Overall, 1972 HCC diagnosed treated at National Cancer Center, Korea between 2004 2009 were enrolled. The data this cohort compared those (2000-2003) from same institution.In all (mean age, 56.4 years; 1642 men), 74.6% was hepatitis B virus (HBV) positive, 81.6% Child-Pugh (CP) class A, 64.4% Barcelona Clinic Liver (BCLC) stage C. modified Union for International...
Abstract Alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation reactive oxygen species. Ubiquinol–cytochrome c reductase hinge protein ( UQCRH ) consists cytochrome bc1 complex serving mitochondria. In present study, we analyzed abnormalities hepatocellular carcinoma HCC its association with clinical outcomes patients. expression was determined semiquantitative quantitative real‐time reverse...
Introduction There is no reliable screening tool to identify people with high risk of developing pancreatic cancer even though represents the fifth-leading cause cancer-related death in Korea. The goal this study was develop an individualized prediction model that can be used screen for asymptomatic Korean men and women. Materials Methods Gender-specific models were developed using Cox proportional hazards based on 8-year follow-up a cohort 1,289,933 557,701 women Korea who had biennial...
<b><i>Objectives: </i></b>Chronic hepatitis B virus (HBV) infection is the most common cause of hepatocellular carcinoma (HCC) in South Korea, but a high prevalence metabolic diseases may result increases incidence cryptogenic HCC (cHCC). We studied characteristics cHCC single-center cohort. <b><i>Methods: </i></b>A cohort 1,784 patients newly diagnosed and treated at National Cancer Center, between 2004 2009 was reviewed analyzed....
The response criteria for complete remission ( CR ) in acute myeloid leukemia AML are currently based on morphology and blood cell counts. However, these insufficient to establish a diagnosis cases with poor quality bone marrow BM samples demonstrating loss of cellular morphology. We investigated whether the sera patients contained biomarkers that indicate disease status. First, we performed multidimensional liquid chromatography‐differential gel electrophoresis MDLC ‐ DIGE generate protein...
Practitioners of complementary and alternative medicine have suggested that acupuncture could alleviate poststroke shoulder pain, based on the clinical evidence. This study protocol is aimed at showing effectiveness safety electroacupuncture therapy for stroke survivors with pain. After assessing their eligibility, 60 pain will be enrolled from two traditional Korean hospitals randomly divided into either verum or sham (EA) group a 1:1 ratio. The participants receive 9 sessions EA procedures...
Despite the recent identification of several prognostic gene signatures, lack common genes among experimental cohorts has posed a considerable challenge in uncovering molecular basis underlying hepatocellular carcinoma (HCC) recurrence for application clinical purposes. To overcome limitations individual gene-based analysis, we applied pathway-based approach analysis HCC recurrence. By implementing permutation-based semi-supervised principal component algorithm using optimal component,...
The objective of this study is to evaluate the relationship atheroembolic risk factors with postoperative recovery renal function after on-clamp partial nephrectomy (PN) warm ischemia in patients staged T1-2 cell carcinoma (RCC).A total 234 from 2004 2012 were included, and their clinicopathologic operative parameters, including reviewed retrospectively. Renal function, as determined by estimated glomerular filtration rate (eGFR) measurement serum creatinine level (Cr) at each scheduled...
Most prognostic models for hepatocellular carcinoma are based on data at the time of diagnosis. However, disease frequently recurs or progresses after initial treatment, with changes in tumor burden and clinical status. Therefore, we developed a risk score model to predict survival patients recurrence progression.Of 1972 newly diagnosed National Cancer Center, Korea, between January 2004 December 2009, 1301 recurrent progressive were enrolled. They randomly classified into development (75%,...
This pilot multicentered, randomized, parallel, sham-controlled trial is intended to evaluate the effectiveness and safety of electroacupuncture therapy for poststroke patients with urinary incontinence. Forty stroke survivors aged >19 years will be recruited in 2 hospitals Republic Korea. Patients who experienced within satisfy criteria frequencies ≥2 either 3 4 points on Patient Perception Intensity Urgency Scale or 13 more Korean version International Prostate Symptom (K-IPSS) identified,...
This study protocol aims to explore the effectiveness, safety, and cost-effectiveness of a herbal medication, Gongjindan (GJD), in patients with chronic dizziness. will be prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group, clinical trial. Seventy-eight diagnosed Meniere’s disease, psychogenic dizziness, or dizziness unknown cause randomized allocated either GJD placebo group 1 : ratio. Participants orally given 3.75 g pill form once day for 56 days. The...
Cervicogenic dizziness is triggered by movement or positioning of the cervical spine and often accompanied neck pain stiffness. This a prospective, pragmatic, assessor-blind, randomized controlled trial aimed at testing efficacy safety adjuvant Chuna Manual Therapy (CMT) in patients with cervicogenic under usual care treatments. Fifty will be randomly allocated to CMT (UC) groups 1 : ratio. Extensive screening procedures, including examinations for central nervous system problems nystagmus,...
Objectives: This study was designed to find out the differences of acupuncture sensation by type pharmacopuncture. And furthermore we try whether normal saline(NS) is able be constituted as an appropriate control group for Calculus Bovis · Fel Ursi Moschus(BUM) pharmacopuncture, mountain ginseng pharmacopuncture and sciatica no. 5 Methods: NS three pharmacopunctures were inserted into ST36, ST37 subjects. Before after treatment, subjects completed a questionnaire rating intensity 13 kinds...
Background and Aim A model to estimate survival in ambulatory hepatocellular carcinoma patients (MESIAH) is useful for estimating patient prognosis but needs improvement Korean patients, most of whom have a hepatitis B virus. We aimed modify the MESIAH better prognostication through enhancing calibration population (K-MESIAH). Methods Utilizing cohort 1,969 (HCC) from National Cancer Center Korea between 2004 2009, prediction was developed using Cox proportional hazards model. The model’s...
Objectives: This study is performed to develop the oriental medical rating scale of knee pain and assess its validity. Methods: 250 patients completed previously accepted pain(VAS, WOMAC(pain, function, stiffness), 6 minute walk test(number steps, distance)) which was developed by Hwang et al at 2012, before after weeks acupuncture treatment. Comparing these results, we assessed validity scale. Results: treatment with VAS, stiffness) distance), showed correlation highest WOMAC(function)....
4045 Background: Due to the very low survival of pancreatic cancer (PC), early detection is a critical strategy improve outcome PC.Screening individuals with genetic syndromes associated high incidence PC or families predisposed increasing. However, those populations account for only 10% all cases. A different approach developing an effective surveillance tool needed identify high-risk without hereditary risks. The goal this study was develop and validate risk prediction models filtering...