A5076559567- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Wnt/β-catenin signaling in development and cancer
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Kruppel-like factors research
- Cytokine Signaling Pathways and Interactions
- Neurogenesis and neuroplasticity mechanisms
- Aldose Reductase and Taurine
- Biochemical Acid Research Studies
- Cancer Mechanisms and Therapy
- T-cell and B-cell Immunology
- Biochemical effects in animals
- Neonatal Respiratory Health Research
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Immune Response and Inflammation
Catholic University of Korea
2004-2025
REGEN Biotech (South Korea)
2024
Korea Research Institute of Bioscience and Biotechnology
2014-2023
Keimyung University
2017
Gachon University
2012
BC Cancer Agency
2006
STUDY QUESTIONIs the decreased natural killer (NK) cell cytolytic activity in peritoneal fluid (PF) of endometriosis patients due to primary cytokine activity?
Abstract With contrasting observations on the effects of β-catenin hematopoietic stem cells (HSCs), precise role Wnt/β-catenin signals HSC regulation remains unclear. Here, we show a distinct mode signal that can regulate HSCs in stroma-dependent manner. Stabilization bone marrow stromal promoted maintenance and self-renewal contact-dependent manner, whereas direct stabilization caused loss HSCs. Interestingly, canonical Wnt receptors accumulation were predominantly enriched rather than...
The immune-modulatory effects of mesenchymal stromal cells (MSCs) are widely used to treat inflammatory disorders, with indoleamine 2,4-dioxygenase-1 (IDO-1) playing a pivotal role in suppressing stimulated T-cell proliferation. Taking that three-dimensional (3D) cultures enhance MSCs’ anti-inflammatory properties compared two-dimensional (2D) cultures, the differentially expressed miRNAs were examined. Thus, we identified hsa-miR-4662a-5p (miR-4662a) as key inducer IDO-1 via its suppression...
Self-renewal of hematopoietic stem cells (HSCs) is key to their reconstituting ability, but the factors regulating process remain poorly understood. Here, we show that Interleukin-10 (IL-10), a pleiotropic immune modulating cytokine, can also play role in HSC self-renewal. First, quantitative decrease primitive cell populations, not more matured cells, was observed bone marrows IL-10 disrupted mice as determined by long-term vitro cultures or vivo competitive repopulation assays. In...
Immune status including the immune cells and cytokine profiles has been implicated in development of endometriosis. In this study, we analyzed Th17 IL-17A peritoneal fluid (PF) endometrial tissues patients with (n=10) without (n=26) Our study shown increased cell population level PF endometriosis patients. To determine roles endometriosis, effect IL-17A, major Th17, on isolated from endometriotic was examined. Recombinant promoted survival accompanied by expression anti-apoptotic genes,...
Mesenchymal stromal cells (MSCs) display heterogeneity in origin and functional role tissue homeostasis. Subsets of MSCs derived from the neural crest express nestin serve as niches bone marrow, but possibility coaxing into nestin-expresing for enhanced supportive activity is unclear. In this study, an approach to chemical MSC functions, we screened libraries clinically approved chemicals identify compounds capable inducing expression MSCs. Out 2000 clinical compounds, chose vorinostat a...