A5002232086- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Blood disorders and treatments
- Hematological disorders and diagnostics
- Bacterial Identification and Susceptibility Testing
- Bone and Joint Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antifungal resistance and susceptibility
- Blood groups and transfusion
- Neonatal Health and Biochemistry
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Hemoglobinopathies and Related Disorders
- Neonatal Respiratory Health Research
- Fungal Infections and Studies
Catholic University of Korea
2015-2024
Seoul St. Mary's Hospital
2016-2024
All India Institute of Medical Sciences
2021
Daejeon St. Mary's Hospital
2020
Korea Health Industry Development Institute
2019
Ministry of Health and Welfare
2019
Although the proportion of Pseudomonas aeruginosa infections has reduced after introduction antibiotics with anti-pseudomonal effects, P. bacteremia still causes high mortality in immunocompromised patients. This study determined clinical characteristics and outcomes antibiotic susceptibilities strains isolated from febrile neutropenic patients.Thirty-one children adolescents underlying hematologic/oncologic disorders diagnosed between 2011 2016 were enrolled study. Their medical records...
Background:The incidence of bacteremia caused by Gram-negative bacteria has increased recently in febrile neutropenic patients with the increase antibiotic-resistant bacterial infections.This study aimed to identify distribution causative and proportion diagnosed children. Materials Methods:The medical records children between 2010 2014 were retrospectively reviewed.The investigated compared yearly during period.The clinical impact infections was also determined.Results: A total 336 episodes...
Recent studies indicate 70-80% event-free survival (EFS) for pediatric acute lymphoblastic leukemia (ALL). In this study, we report the outcome of 295 children and adolescents treated at our institution, with stratification into four risk groups, omission cranial irradiation in all patients.Patients were diagnosed from January 2005 to December 2011 classified as low, standard, high, very high groups. A delayed intensification phase was given twice None patients received central nervous...
Invasive pulmonary aspergillosis (IPA) is the most common invasive fungal disease in immunocompromised patients, and it has a 30 % mortality rate despite appropriate antifungal therapy. This retrospective study was performed to determine risk factors for children with IPA.Medical records of 45 probable/proven IPA cases diagnosed hematologic/oncologic diseases were reviewed. Selected divided into survival (n = 30) fatality 15) groups based on at 12 weeks after Clinical characteristics serum...
Pulmonary Aspergillosis in Korean Children with Hematologic/Oncologic DiseasesInvasive pulmonary aspergillosis (IPA) is the most frequent form of invasive fungal diseases immunocompromised patients.However, there are only a few studies on IPA children Korea.This study was designed to characterize hematologic/oncologic diseases.Medical records receiving antifungal therapy were reviewed.The enrolled divided into group (proven and probable IPA) non-IPA group, clinical characteristics prognosis...
BACKGROUND Hereditary hemolytic anemia (HHA) is a rare disease characterized by premature red blood cell (RBC) destruction due to intrinsic RBC defects. The Disorder Working Party of the Korean Society Hematology established and updated standard operating procedure for making an accurate diagnosis HHA since 2007. aim this study was investigate nationwide epidemiology HHA. METHODS We collected data newly diagnosed pediatric cohort (2007-2016) compared cohort's characteristics with those...
Background Autoimmune cytopenia (AIC) is a rare complication of allogeneic hematopoietic cell transplantation (HCT). In this study, we reviewed the diagnosis, treatment and response to therapy for pediatric patients with post-HCT AIC at our institution. Methods Of 292 HCTs performed from January, 2011 December, 2015 Department Pediatrics, The Catholic University Korea, seven were complicated by AIC, resulting in an incidence 2.4%. Results All had received unrelated donor transplant. Six...
Abstract Background: Despite the introduction of a polymerase chain reaction (PCR) test for diagnosis respiratory viral infection (RVI), guidance on application this and management RVI in immunocompromised children is lacking. This study evaluated clinical characteristics established strategies PCR adolescents with hematological malignancies.Methods: included underlying malignancies symptoms, whom multiplex was performed. Patients identified not were categorized into Groups I II,...
ETV6/RUNX1 (+) acute lymphoblastic leukemia (ALL), which is the most common genetic subtype of pediatric ALL, has a favorable prognosis. In this study, we analyzed outcome ALL patients treated at our institution with aim identifying significant prognostic variables.Sixty-three were diagnosed from 2005 to 2011. Prognostic variables studied included minimal residual disease (MRD) as detected by fusion, and presence additional cytogenetic abnormalities.The 5-year event-free survival was...
Although intravenous acyclovir therapy is recommended for varicella zoster virus (VZV) infection in immunocompromised children, the clinical characteristics and outcomes of VZV era have rarely been reported.The medical records children diagnosed with or herpes virus, who had underlying hematologic malignancies, were retrospectively reviewed, evaluated.Seventy-six episodes (herpes 57 19) identified 73 children. The median age was 11 years (range, 1-17), 35 (46.1%) occurred boys. Acute...
We conducted a retrospective study on 51 pediatric patients with newly diagnosed chronic myeloid leukemia phase or accelerated phase. The were classified into the IMA group (N = 33), treated imatinib, and DSA 18), dasatinib, as front-line tyrosine kinase inhibitors (TKIs). At 12 months, rates of complete cytogenetic response similar between (92.3%) (100%) (p 0.305). However, rate early molecular was higher in than (100.0% vs. 80.0%, p 0.043). By 24 showed faster cumulative both major (DSA...
Background: Acute myeloid leukemia with the t(8;21)(q22;q22) rearrangement ( RUNX1-RUNX1T1 (+) AML) is known to have a favorable prognosis. Our study aimed determine most important prognostic variables among an aggregate of clinical, genetic, and treatment response-based factors in pediatric AML. Materials Methods: We analyzed characteristics outcome 40 patients who were diagnosed treated for AML from April 2008 December 2016 at our institution. Results: A<−2.2 log fusion transcript...
Whether plasma MTX concentrations and MTHFR C677T A1298C polymorphisms could be used as a predictor of occurrence MTX-related toxicities in Korean paediatric patients with acute lymphoblastic leukaemia (ALL) were assessed. HD-MTX related toxicities, following 337 cycles to 117 children ALL on maintenance therapy analyzed. A significantly higher frequency hyperbilirubinemia (P = 0.0443) renal toxicity 0.0107) associated high by Fisher's exact test. Moreover, at 24 h, 48, 72 h increased...
Purpose: This study aimed to investigate the clinical factors associated with bone mineral density (BMD) among children and adolescents osteoporosis secondary treatment for underlying conditions.Methods: We retrospectively reviewed medical records of patients aged 10–18 years evaluated them lumbar spine BMD (LSBMD) after diseases, including hemato-oncologic, rheumatologic system, inflammator y bowel diseases. LSBMD measured by dual-energy x-ray absorptiometry (DXA) performed from March 2019...
Lifelong treatment of pediatric chronic myeloid leukemia (CML) patients with tyrosine kinase inhibitors (TKIs) can affect their growth and development. For these reasons, clinical trials have explored the feasibility TKI discontinuation in children a sufficient response. We evaluated analytical performance digital droplet PCR (ddPCR) to quantify BCR-ABL1 compared results reverse transcription quantitative polymerase chain reaction (RT-qPCR). further investigated whether ddPCR could be used...
Although acyclovir prophylaxis against varicella zoster virus (VZV) infection for ≥1 year is recommended after allogeneic hematopoietic cell transplantation (HCT), the emergence of acyclovir-resistant viruses and adverse drug effects cannot be ignored. We investigated cumulative incidence VZV HCT in children receiving a shorter duration than evaluated appropriateness short prophylaxis. Medical records 217 who received were retrospectively reviewed until median 25 months (range = 1–59 months)...
Background Thyroid function in children with leukemia during the first year after hematopoietic stem cell transplantation (HSCT) was investigated. Methods The medical records of 186 subjects [111 boys and 75 girls; lymphoid=75, myeloid=111; median age at HSCT 10.7 (0.8-21.8) years old] were reviewed retrospectively. Results In leukemia, T3 decreased 1 month (p<0.001) recovered 9 months to levels before HSCT. TSH (p<0.001), 3 increased 12 incidence euthyroid sick syndrome (ESS, 23.2%, 15.5%,...
Objective: This study aimed to determine prognostic factors associated with mortality in pediatric oncology patients admitted the intensive care unit (ICU) pulmonary complications. Materials and Methods: retrospective cohort included 21 years of age underlying oncologic diseases ICU a Korean Tertiary Referral Hospital complications from April 2009 March 2017. Patients for perioperative management or nonpulmonary were excluded. Demographic, laboratory, clinical parameters (eg, Glasgow Coma...
Recent advances in genetic analysis have led to the discovery of novel subtypes precursor B-cell acute lymphoblastic leukemia (B-ALL) with prognostic relevance. In this study, we studied a cohort pediatric B-ALL patients retrospectively determine incidence harboring subtypes, as well their outcome.B-ALL (N = 190) diagnosed single Korean hospital were included study. Patients' medical records reviewed for data on established abnormalities and outcome. CRLF2 expression was analyzed by...
Recent cooperative trials in pediatric acute lymphoblastic leukemia (ALL) report long-term event-free survival (EFS) of greater than 80%. In this study, we analyzed the outcome and prognostic factors for patients with precursor B cell ALL (n=405) diagnosed during a 10-year period (2005-2015) at our institution.All were treated uniform institutional regimen based on four risk groups, except steroid type; up till 2008 receiving dexamethasone, while subsequent received prednisolone. None...
Purpose Effectiveness and safety of clofarabine (one the treatment mainstays in pediatric patients with relapsed/refractory acute lymphoblastic leukemia [ALL]) was assessed Korean ALL to facilitate conditional coverage evidence development.Materials Methods In this multicenter, prospective, observational study, receiving as mono/combination therapy were followed up every 4-6 weeks for 6 months or until hematopoietic stem cell transplantation (HSCT). Response rates, survival outcomes, adverse...