A5031824843- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Obesity, Physical Activity, Diet
- Diabetes and associated disorders
- Birth, Development, and Health
- Diabetes Management and Research
- Bone and Joint Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Lymphoblastic Leukemia research
- Pancreatic function and diabetes
- Bone health and osteoporosis research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Sexual Differentiation and Disorders
- Ovarian function and disorders
- Regulation of Appetite and Obesity
- Hypothalamic control of reproductive hormones
- Hormonal and reproductive studies
- Nutrition and Health in Aging
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Bone health and treatments
- Neonatal Health and Biochemistry
- Infant Nutrition and Health
Catholic University of Korea
2016-2025
Seoul St. Mary's Hospital
2010-2025
Weatherford College
2013-2023
Kirin (Japan)
2023
University of Nevada, Reno
2017
Pediatrics and Genetics
2016
BACKGROUND: The risk of weight gain as a consequence school closure in children during the coronavirus disease-2019 (COVID-19) pandemic has been recognized. This study was performed to investigate changes anthropometric and metabolic parameters following 6-month period social distancing due pandemic. METHODS: retrospective cohort conducted school-aged that were on routine follow-up at Growth Clinic Seoul St. Mary's Hospital. Changes body mass index (BMI) standard deviation scores (z-scores),...
Background Irisin is an adipomyokine secreted by muscle and adipose cells, it plays a role in glucose, fat, bone metabolism. This study aimed to determine the correlation of serum irisin levels with anthropometric, metabolic, parameters obese children adolescents. Methods single-center included 103 Korean adolescents: 54 (52.4%) participants body mass index (BMI) ≥95th percentile 49 (47.6%) healthy controls BMI within 15th 85th percentile. Various were measured, including fasting blood...
Purpose: Patients with juvenile-onset systemic lupus erythematosus (JSLE) are at a high risk of entering adulthood disease-related morbidities like reduced bone mass and osteoporosis. This study aimed to evaluate the clinical characteristics JSLE analyze factors associated low mineral density (BMD) in these patients.Methods: Children adolescents diagnosed single institution Korea were included. Demographic, clinical, laboratory data as well details about use glucocorticoids (GCs)...
The major histocompatibility complex region has been suggested to play an important role in the development of autoimmune thyroid disease (AITD). In this study, we investigated associations human leukocyte antigen (HLA) alleles and amino acid variants HLA with early-onset AITD. class I II genes were analyzed 116 Korean children AITDs (Graves' [GD]: 71, Hashimoto's [HD]: 45) 142 healthy controls. HLA-B*46:01 (OR = 3.96, Pc 0.008), -C*01:02 2.51 0.04), -DPB1*02:02 3.99, -DPB1*05:01 4.6, 0.003)...
Juvenile-onset systemic lupus erythematosus (JSLE) is a chronic autoimmune disease affecting individuals under 18, causing multi-system impairment. Patients with JSLE exhibit more severe when compared to patients adult-onset SLE. This study aimed evaluate the prevalence of endocrine and metabolic comorbidities in JSLE, analyze factors associated each comorbidity. Anthropometric, clinical, laboratory data, details glucocorticoids disease-modifying anti-rheumatic drugs use were collected. A...
Background/Objective: With increasing cases of osteoporosis in children and adolescents, the need for timely diagnosis, management, follow-up has become important. This study aimed to determine whether bone turnover markers (BTMs), particularly serum bone-specific alkaline phosphatase (BsALP) C-telopeptide collagen type 1 (CTx), accurately reflect BMD. Methods: In this retrospective study, 280 post-puberty males females who were previously diagnosed with hemato-oncologic, rheumatic,...
Acute lymphoblastic leukemia (ALL), currently the most common pediatric leukemia, has a high curability rate of up to 90%. Endocrine disorders are highly prevalent in children with ALL, and skeletal morbidity is major issue induced by multiple factors associated ALL. Leukemia itself predominant risk factor for decreased bone formation, destruction occurs secondary chemotherapeutic agents. Glucocorticoids cornerstone drugs used throughout course ALL treatment that exert significant effects on...
Discontinuing growth hormone (GH) treatment during the transition to adulthood has been associated with adverse health outcomes in patients childhood-onset deficiency (CO-GHD). This study investigated metabolic changes interrupting GH adolescents CO-GHD period.This included 187 who were confirmed have adult GHD and treated at six academic centers Korea. Data on clinical parameters, including anthropometric measurements, profiles, bone mineral density (BMD) end of childhood treatment,...
Purpose The purpose of this study was to investigate the relationships physical fitness and obesity with metabolic risk factors in children adolescents. Methods This cohort conducted Chungju city, South Korea. Total 843 subjects were enrolled, including 193 elementary school 4th grade male (E4M), 189 female (E4F) 461 male-middle students (M1M). also classified into 2 groups by body mass index; normal weight (NW) group overweight included (OW/OB) group. Physical measured shuttle run...
Purpose Childhood obesity frequently persists into adulthood and is associated with insulin resistance (IR) increased long-term morbidity mortality. We compared IR criteria concerning 'age-specific cutoff point' (ACOP) 'fixed (FCOP) for the identification of investigated their correlation metabolic syndrome (MS). Methods Data were acquired from 5th Korea National Health Nutrition Examination Survey (2010–2011). Participants ranged 10 to 17 years age underwent fasting plasma glucose,...
Background . Toll-like receptors ( TLRs ) have been suggested to be associated with the development of AITD. Methods Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed 104 Korean children (girls = 86, boys 18) AITD (Hashimoto disease (HD) 44, Graves’ (GD) 60, thyroid-associated ophthalmopathy (TAO) 29, and non-TAO 31) 183 controls. Results. GD showed higher frequencies TLR4 rs1927911 C allele than control. TAO a lower frequency CT genotype CC The TLR9 rs187084 was that...
Abstract Nesfatin-1, a recently discovered anorexigenic neuropeptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis. The aim of this study was evaluate the relation serum nesfatin-1 level with metabolic anthropometric parameters children adolescents. This prospectively included 78 Korean adolescents (42 obese/overweight group 36 healthy control group). Fasting quantitatively assayed by ELISA. Lipid profile, fasting blood glucose,...
Growth hormone (GH) is an essential element for normal growth. However, reports of growth without GH have been made in patients who undergone brain surgery craniopharyngioma. Normal can be explained by hyperinsulinemia, hyperprolactinemia, elevated leptin levels, and variants; however, its exact mechanism has not elucidated yet. We diagnosed a female patient aged 13 with combined pituitary deficiency (CPHD) caused stalk interruption syndrome (PSIS). The experienced recurrent hypoglycemic...
To analyze the correlation between serum alanine aminotransferase (ALT) and obesity indices including body mass index (BMI), fat percentage (BFP), total (FM), truncal (TFM), waist circumference (WC), waist-to-height ratio (WHtR) in Korean adolescents.This was a cross-sectional study based on data derived from 2010-2011 National Health Nutrition Examination Surveys (KNHANES). Subjects were adolescents aged 10-18 years (871 total; 475 boys 396 girls) who participated KNHANES.In both sexes,...
We conducted a retrospective study on 51 pediatric patients with newly diagnosed chronic myeloid leukemia phase or accelerated phase. The were classified into the IMA group (N = 33), treated imatinib, and DSA 18), dasatinib, as front-line tyrosine kinase inhibitors (TKIs). At 12 months, rates of complete cytogenetic response similar between (92.3%) (100%) (p 0.305). However, rate early molecular was higher in than (100.0% vs. 80.0%, p 0.043). By 24 showed faster cumulative both major (DSA...
We investigated the effect of overweight on luteinizing hormone (LH) levels after a gonadorelin stimulation test in Korean girls with idiopathic central precocious puberty (CPP).Medical records 234 diagnosed CPP were reviewed retrospectively. was when peak LH >5.0 U/L. The enrolled had level U/L test. Selected classified as normoweight (body mass index [BMI] below 85th percentile respect to age) and (BMI greater than age).The (8.95±2.85 vs. 11.97±8.42 U/L, P<0.01) follicle-stimulating...
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with an increasing worldwide incidence. IBD frequently diagnosed during childhood in adolescent period ongoing growth and development, it can affect patients' linear growth, puberty, nutrition, bone health. Therefore, its treatment monitoring are critical to prevent secondary outcomes. However, few studies have highlighted association between pediatric skeletal outcomes Asian populations. We...
In this study, we investigated bone mineral deficits in children who survived childhood acute leukemia and explored the association between insulin-like growth factor-1 (IGF-1) level density (BMD). This retrospective analysis enrolled 214 patients treated for leukemia, measuring various factors including height, weight, body mass index (BMI), lumbar spine BMD after end of treatment. The study found an overall prevalence low 15% participants. Notably, IGF-1 levels were significantly different...
This study aimed to investigate the impact of hypogonadism on bone mineral density (BMD) in children and adolescents with chronic diseases determine relationship between sex hormones BMD. retrospective included 672 such as hemato-oncologic, rheumatoid, gastrointestinal, endocrinologic diseases. The sex- Tanner-stage-matched Z-scores for age-matched lumbar spine BMD (LSBMD) was evaluated. Adjustments were made confounders underlying diseases, age at diagnosis, age- sex-matched body mass index...
Purpose This study aimed to investigate the association between skeletal maturation and adrenal androgen levels in obese children adolescents. Methods Fifty-three adolescents (aged 7–15 years) diagnosed as or overweight were investigated. Anthropometric measurements, bone age (BA) determination, serum biochemical analyses, hormonal measurements performed. The difference BA chronological (BA–CA, dBACA) was calculated used represent degree of advanced maturation. Results Thirty-one subjects...
Abstract Autoimmune thyroid disease (AITD) is predominant in females and has been focused on the sexual diploid immune response. The IL-1 receptor-associated kinase 1 (IRAK1) gene X chromosome was recently suggested as strong autoimmune disease-susceptible loci, second to major histocompatibility complex region. We investigated frequency of IRAK1 single-nucleotide polymorphisms (SNPs) children with AITD. In this study, we observed that SNPs including rs3027898, rs1059703, rs1059702 115...
(1) Background: Autoimmune thyroid diseases (AITDs) are female predominant and much attention has been focused on G protein-coupled receptor 174 (GPR174) integral membrane protein 2A (ITM2A) the X chromosome as Grave's disease (GD) susceptible locus. (2) Methods: We genotyped four single nucleotide polymorphisms (SNPs), rs3810712, rs3810711, rs3827440, rs5912838, of GPR174 ITM2A in 115 Korean children with AITD (M = 25 F 90; GD 74 (14.7 ± 3.6 years), HD 41 (13.4 3.2 years);...
Purpose: This study aimed to investigate the clinical factors associated with bone mineral density (BMD) among children and adolescents osteoporosis secondary treatment for underlying conditions.Methods: We retrospectively reviewed medical records of patients aged 10–18 years evaluated them lumbar spine BMD (LSBMD) after diseases, including hemato-oncologic, rheumatologic system, inflammator y bowel diseases. LSBMD measured by dual-energy x-ray absorptiometry (DXA) performed from March 2019...