Background: Acute abdominal pain is a common yet clinically challenging symptom in pediatrics. Its potential causes range from self-limited conditions to life-threatening emergencies. Proper evaluation requires thorough understanding of age-specific diseases, their clinical presentations, and appropriate diagnostic approaches. This review summarizes key considerations the differential diagnosis acute children, emphasizing importance age-stratified management.Current Concepts: The children...

Understanding the virulence and pathogenicity of invasive nontyphoidal Salmonella (iNTS) in children may support timely treatment enable closer monitoring chronic infections. iNTS epidemiology Asia remains inadequately described. We analyzed genetic diversity genes associated with extra-intestinal invasion Korean children. isolates from <18 yrs age diagnosed moderate-to-severe salmonellosis between January 2019 December 2021 were subjected to antibiotic susceptibility testing whole-genome...

Abstract Purpose This study aimed to investigate the role of rapid syndromic diagnostic testing gastrointestinal pathogens as a clinical decision support tool in pediatric emergency department (ED) by comparing and patient outcome parameters pre- post-implementation. Methods was big data analytical children &lt; 18 years old without any underlying diseases, that visited ED with acute moderate severe diarrhea during 34-month period from 2018 2022 using Seoul St. Mary’s hospital’s healthcare...

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare congenital neoplasm that originates from the neural crest cells, which give rise to melanocytes skin and leptomeninges. We report case MNTI with neurocutaneous melanosis 28-month-old girl. She was born hydrocephalus several large giant nevi. There were no findings except for hydrocephalus, after ventriculoperitoneal (VP) shunt operation performed when she 6 months old. operated on growing inguinal mass at 8 months. The specimen sac...

Background: Eosinophilic gastrointestinal disorder (EoGID) is an emerging disease condition in Korean children, but its diagnosis requires invasive endoscopic biopsies.Fecal calprotectin (FCal) a noninvasive biomarker for intestinal inflammation to differentiate organic diseases from functional abdominal pain disorder.This study aimed evaluate the diagnostic accuracy of FCal and determine optimal cutoff EoGID disorder.Methods: A total 253 children (122 boys, 131 girls; mean age 12.2 ± 3.6,...

Conventional methods for etiologic diagnoses of acute gastroenteritis (AGE) are time consuming and have low positive yield leading to limited clinical value. This study aimed investigate quality improvements in patient management, antibiotic stewardship, in-hospital infection transmission prevention using BioFire® FilmArray® Gastrointestinal Panel (GI Panel) children with diarrhea. was a prospective recruiting &lt; 19 years old new onset diarrhea during the period, matched historical cohort...

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with an increasing worldwide incidence. IBD frequently diagnosed during childhood in adolescent period ongoing growth and development, it can affect patients' linear growth, puberty, nutrition, bone health. Therefore, its treatment monitoring are critical to prevent secondary outcomes. However, few studies have highlighted association between pediatric skeletal outcomes Asian populations. We...

Intussusception refers to the invagination of a part intestine into itself. The exact cause for this condition is unknown in most cases. active implementation coronavirus disease 2019 (COVID-19) infection control guidelines has reduced spread COVID-19 and incidence other infectious diseases children. current study aimed identify changes pediatric intussusception after confirm association between contagious diseases.We analyzed electronic medical records patients diagnosed with from seven...

Abstract Background While Helicobacter pylori ( H. ) ulcers has declined recently, -negative and/or gastrotoxic drug-negative peptic (HNGN-PU) increased. This study aimed to analyze the etiology of in children and differences clinical, laboratory, endoscopic, histopathologic findings according etiology, including eosinophilic gastroenteritis (EoGE). Methods In total, 255 (157 boys 98 girls) with were recruited. The subjects categorized into 5 groups ulcer: 1) infection n = 51); 2) drugs 18);...

The primary aim of this study was to investigate the compositional differences first passed meconium microbiome in preterm and term infants, secondary compare microbiomes infants that later developed necrotizing enterocolitis (NEC)/Feeding intolerance (FI) compared those did not develop NEC/FI. During period, a total 108 newborns' occurring within 72 hours birth were collected analyzed. Meconium showed disruption percentages core constituents both phylum genus levels born < 30 weeks...

We present a case of Bannayan-Riley-Ruvalcaba syndrome (BRRS) diagnosed during the treatment recurrent iron deficiency anemia (IDA).IDA is most common hematological disorder in children and often caused by dietary problem or obesity.However, relatively rare cases, it gastrointestinal (GI) disease.BRRS genetic characterized macrocephaly, multiple noncancerous tumors, intestinal hamartomatous polyps, penile freckling due to defect PTEN gene.GI polyps can cause chronic GI bleeding, leading IDA...

The prevalence of nonalcoholic steatohepatitis (NASH) is increasing with the childhood obesity. Although NASH has a high risk progression to liver fibrosis and cirrhosis, few studies have reported noninvasive markers for predicting hepatic in children. This study aimed evaluate compare diagnostic accuracies serologic biomarkers scoring systems obese children NASH.

Objective: This study aimed to compare the efficacy and tolerability of azithromycin clarithromycin in pediatric Campylobacter enterocolitis. Methods: A prospective, randomized, controlled trial was conducted at a single center. Patients with confirmed enterocolitis were randomly assigned receive either 3-day course or 5-day clarithromycin. Symptoms monitored daily, changes laboratory markers (WBC counts, CRP levels, stool calprotectin) compared. Results: total 29 patients included, 14 group...

The association between nonalcoholic fatty liver disease (NAFLD) and sarcopenia has been suggested. We investigated sarcopenia's impact on NAFLD severity its relationship with cardiometabolic risk in adolescents. conducted a retrospective study 122 patients aged 13-18 years diagnosed both by laboratory tests, abdominal ultrasound (US), multifrequency bioelectrical impedance analysis. Sarcopenia was stratified into tertiles based the skeletal muscle-to-fat ratio (MFR), established US,...

Neonatal lupus can occur in infants born to mother with autoimmune disorders through transplacental auto-antibodies. Clinical manifestations neonatal include cutaneous lesions and hematologic or hepatobiliary findings resembling those seen systemic erythematosus. In state, macrophage activation syndrome (MAS) represent a critical potentially fatal complication that result mortality if not immediately identified managed the appropriate care. Here we present 33-day-old girl diagnosed serious...

This study aim to evaluate the relationship between Hill grade confirmed by esophagogastroduodenoscopy (EGD) and degree of gastroesophageal reflux (GER) 24-hour multichannel intraluminal impedance-pH monitoring (MII-pH) in children suspected having disease (GERD).A retrospective review 105 adolescents who underwent EGD MII-pH for evaluation GERD from March 2013 July 2019 was performed. Clinical features results were collected statistically analyzed.Hill grades 1, 2, 3, 4 identified using 56...

Hiatal hernia is clinically important because it impairs the protective mechanism that prevents gastroesophageal reflux-induced injury. Diagnosing hiatal more in neurologically impaired children hernia-induced reflux often causes severe complications such as aspiration pneumonia or malnutrition. We aimed to evaluate patient characteristics and early predictors of children.We retrospectively investigated 97 who underwent esophagogastroduodenoscopy upper gastrointestinal series between March...

Gastrointestinal (GI) bleeding is a rare adverse event of dasatinib, which known to be caused by dasatinib-induced colitis, severe thrombocytopenia, and platelet dysfunction. We present two cases pediatric patients who developed hematochezia during treatment with dasatinib after hematopoietic stem cell transplantation (HSCT). A colonic tissue biopsy was performed differentiate the cause GI bleeding. Both were diagnosed proven cytomegalovirus (CMV) but only one treated ganciclovir. The...

Abstract Objectives The prevalence of nonalcoholic steatohepatitis (NASH) is increasing with the childhood obesity. Although NASH has a high risk progression to liver fibrosis and cirrhosis, few studies have reported on noninvasive markers for predicting hepatic in children. This study aimed evaluate compare diagnostic accuracy serologic biomarkers scoring systems obese children NASH. Methods A total 99 were diagnosed based biopsy findings, divided into two groups according degree fibrosis:...

Iron deficiency is the most common nutritional in children and adolescents.Pediatric collagenous gastritis (CG) a rare gastrointestinal disorder.Abdominal pain associated with iron anemia (IDA) clinical symptom.We present three cases of pediatric CG diagnosed during treatment recurrent IDA.During esophagogastroduodenoscopy (EGD), nodularity gastric corpus was observed, which characteristic finding patients CG.Although could not be by general EGD biopsy pathological examination, it after...

Abstract Background: While Helicobacter pylori ( H. ) ulcers has declined recently, -negative and/or gastrotoxic drug-negative peptic (HNGN-PU) increased. This study aimed to analyze the etiology of in children and differences clinical, laboratory, endoscopic, histopathologic findings according etiology, including eosinophilic gastroenteritis (EoGE). Methods: In total, 255 (157 boys 98 girls) with were recruited. The subjects categorized into 5 groups ulcer: 1) infection (n = 51); 2) drugs...

Abstract Background: While Helicobacter pylori ( H. ) ulcers has declined recently, -negative and/or gastrotoxic drug-negative peptic (HNGN-PU) increased. This study aimed to analyze the etiology of in children and differences clinical, laboratory, endoscopic, histopathologic findings according etiology, including eosinophilic gastroenteritis (EoGE). Methods: In total, 255 (157 boys 98 girls) with were recruited. The subjects categorized into 5 groups ulcer: 1) infection (n = 51); 2) drugs...

The diagnosis of hiatal hernia (HH), causing severe gastroesophageal reflux disease and complications in children with cerebral palsy (CP) is cumbersome because invasive investigations are required for diagnosis. Hip displacement, one the most common CP, can be diagnosed a simple pelvic radiograph. This study aimed to evaluate association between severity hip displacement HH diagnostic accuracy Reimers' migration percentage (MP) on radiography assessing presence HH. A total 52 CP (27 boys,...