A5021784998- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Platelet Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Respiratory viral infections research
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Pneumonia and Respiratory Infections
- Blood groups and transfusion
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Kawasaki Disease and Coronary Complications
- Chronic Lymphocytic Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Coronary Artery Anomalies
- Pediatric Urology and Nephrology Studies
- Hematopoietic Stem Cell Transplantation
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Cardiac tumors and thrombi
- Pediatric health and respiratory diseases
- Histiocytic Disorders and Treatments
Gachon University Gil Medical Center
2006-2022
Gachon University
2010-2020
Deleted Institution
2004-2017
Charles R. Drew University of Medicine and Science
2006-2011
Inje University Sanggye Paik Hospital
2008
St. Jude Children's Research Hospital
1995-1999
Perivascular epithelioid tumor (PEComa), a recently defined tumor, is very rare disease affecting various organs, most often the uterus. This displays variety of histologic and clinical features at this point regarded as with uncertain malignant potential. A 9-year-old girl abdominal pain vaginal spotting was diagnosed PEComa uterus metastasis. She received chemotherapy comprising vincristine, ifosfamide, doxorubicin, well radiotherapy after surgery. After multimodal treatment, there no...
In Kawasaki disease (KD), high dose intravenous immunoglobulin (IVIG) significantly lowers the coronary complications. However, some patients either do not respond to initial therapy or develop We aimed identify predictive factors for unresponsiveness IVIG and artery dilatation (CAD; defined by Z-score≥2.5) in acute phase convalescent phase.A retrospective review was conducted of 703 with KD, admitted Gachon University Gil Medical Center between January 2005 June 2013. The were divided into...
Anthracyclines have been utilized in the treatment of children with acute lymphoblastic leukemia (ALL). Recent studies shown that anthracyclines may induce toxicity vascular endothelium. This study was performed using brachial artery reactivity (BAR) to evaluate endothelial function ALL patients who were treated anthracycline chemotherapy.We included 21 received chemotherapy and 20 healthy children. The cumulative dose 142.5±18.2/m(2). last administered 2 85 months prior their examination...
The burden of respiratory syncytial virus (RSV) in neonates has not been clearly studied. aims this study were to determine the overall distribution viruses hospitalized with acute lower tract infectiosns (ALRI) and describe clinical characteristics RSV infections these neonates.From January 2009 through May 2010, aged <1 month who ALRI did have underlying disease included study. Viruses identified on multiplex reverse transcription polymerase chain reaction using nasal swab samples....
Purpose: Meckel's diverticulum (MD) has various clinical manifestations, and diagnosis or selectection of proper diagnostic tools is not easy.This study was conducted in order to assess the differences MD diagnosed by scintigraphic non-scintigraphic methods find tools.Methods: We a retrospective review ofthe clinical, surgical, radiologic, pathologic findings 34 children with symptomatic MD, who were admitted
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis of an unknown origin. The prognosis ECD variable, and it mainly depends on the involved anatomic sites. treatment modalities have not been standardized. Interferon-alpha (IFN) has reported to be effective in management ECD. We report here uncommon case with 17-year-old female who had multiple lesions whole body she was treated chemotherapy IFN. She remained disease-free for 2 years after completion treatment.
Norovirus Infections in Asymptomatic Food Handlers Elementary Schools without Outbreaks Some Regions of Incheon, Korea (NV) has caused large outbreaks gastroenteritis schools.Studies NV epidemiology schools related to have been frequently reported.However, reports that are not found.Presently, molecular surveillance was carried out asymptomatic food handlers working at nonoutbreak elementary Korea, March, April and December, 2009.NV prevalence examined by real-time reverse transcription-PCR...
Epstein-Barr virus (EBV)-associated T-cell/natural killer (NK)-cell lymphoproliferative disorders (EBV-T/NK-LPDs) accompany severe chronic active EBV infection (CAEBV) or comprise the CAEBV disease entity. The entity has common feature of lymphoproliferation T NK cells (primarily), and B (rarely), with activation infection. is rare seems to be more prevalent in East Asian countries. encompasses heterogenous disorders, including hydroa vacciniforme (HV), hypersensitivity mosquito bites,...
We aimed to compare the therapeutic efficacy of prolonged macrolide (PMC), corticosteroids (CST), doxycycline (DXC), and levofloxacin (LFX) against macrolide-unresponsive Mycoplasma pneumoniae (MP) pneumonia in children evaluate safety secondary treatment agents.We retrospectively analyzed data patients with MP hospitalized between January 2015 April 2017. Macrolide-unresponsiveness was clinically defined a persistent fever ≥ 38.0°C at 72 hours after treatment. The cases were divided into...
Mycoplasma pneumoniae (MP) infection is a major cause of respiratory in school-aged children. Extrapulmonary manifestations MP are common, but liver involvement has been rarely reported. The aim this study was to determine the clinical characteristics MP-associated hepatitis.This prospective included 1,044 pediatric patients with diagnosed serologically IgM at one medical center from January 2006 December 2012. Eighty these had elevated levels serum aspartate aminotransferase (AST) and...
Objective The aim of this study is to compare the efficacy and safety a single dose anti-D immunoglobulin (anti-D) at 50 μg/kg intravenous (IVIG) in Korean children with acute immune thrombocytopenic purpura (ITP). Methods We performed prospectively by randomly administering 2 consecutive doses IVIG 1.0 g/kg/dor upon initial diagnosis ITP. platelet count adverse events, including hemoglobin concentration, were then serially evaluated, responses compared. Results likelihood having greater...
Different Clinical Phenotypes in Familial Severe Congenital Neutropenia Cases with Same Mutation of the ELANE GeneSevere congenital neutropenia (SCN) is a heterogeneous group disorders defect granulopoiesis causing marked and severe bacterial infections.A 17-monthold girl (patient 1) was admitted due to cervical lymphadenitis caused by methicillinresistant Staphylococcus aureus, neutropenia.She had Pseudomonas aeruginosa sepsis peritonitis perforated appendicitis at 8-month age.Her sister,...
FLT3 mutations are common genetic changes, and reported to have prognostic significance in acute myeloid leukemia (AML). The internal tandem duplication (ITD) the D835 activating mutation tyrosine kinase domain (TKD) were analyzed by polymerase chain reaction (PCR) genomic DNA of Korean patients with AML at diagnosis during follow-up. There 226 enrolled between March 1996 August 2005. incidence ITD TKD was 13% (29/226) 3% (6/226). When compared Western other Asian AML, had a lower frequency...
A 7-year-old boy presented with an undifferentiated embryonal sarcoma of the liver (UESL), which is a rare pediatric neoplasm that originates from mesenchyme. F-18 FDG PET/CT associated separately acquired contrast-enhanced CT was performed to evaluate status tumor during postoperative chemotherapy, followed initial neoadjuvant chemotherapy (vincristine, cisplatin, adriamycin, cyclophosphamide, and actinomycin-D) radical resection. Evaluation demonstrated presence highly metabolic lesion in...
Posterior reversible encephalopathy syndrome (PRES) is an uncommon but distinctive clinical–radiologic entity characterized by headache, seizures, visual disturbance, and altered mental function associated with white matter edema affecting the posterior parietal occipital lobes of brain. Although PRES caused a variety conditions, acute elevation blood pressure, fluid retention, treatment immunosuppressive drugs and/or anti-neoplastic agents are main causes. A few cases hematopoietic stem...
Lynch syndrome is the most common inherited colon cancer syndrome. Patients with develop a range of cancers including colorectal (CRC) and carry mutation on one mismatched repair (MMR) genes. Although CRC usually occurs after fourth decade in patients harboring heterozygous MMR gene mutation, it can occur children who have compound or homozygous mutation. We report case 13-year-old patient congenital heart disease. This had MLH1 (an gene), but no defects, K-RAS somatic cells.
Purpose: Crohn's disease (CD) can involve any site of the gastrointestinal tract (GIT).However, characteristics upper GIT involvement in CD are unclear, especially Eastern pediatric population.This study aimed to estimate prevalence and identify clinical features Korean children with CD.Methods: This was a retrospective multicenter cohort that included 52 patients who underwent esophagogastroduodenoscopy biopsy.The symptoms endoscopic histologic were identified according presence or absence...
Purpose Effectiveness and safety of clofarabine (one the treatment mainstays in pediatric patients with relapsed/refractory acute lymphoblastic leukemia [ALL]) was assessed Korean ALL to facilitate conditional coverage evidence development.Materials Methods In this multicenter, prospective, observational study, receiving as mono/combination therapy were followed up every 4-6 weeks for 6 months or until hematopoietic stem cell transplantation (HSCT). Response rates, survival outcomes, adverse...
Acute lymphoblastic leukemia (ALL), a primary hematologic malignancy that is especially common in childhood, occurs relatively rarely as secondary malignant neoplasm. Available data indicate ALL often follows chemoradiotherapy for soft tissue sarcoma. Perivascular epithelioid tumor (PEComa), primitive mesenchymal origin, can be classified An 11-year-old girl was diagnosed with to (vincristine, ifosfamide, and anthracycline) radiotherapy comprising 45 Gy the whole pelvis PEComa. ALL, FAB L2,...
Objectives: The aim of this study is to confirm the clinical and histopathologic findings ovarian tumors determine malignancy before operation. It will attribute early diagnosis, determining direction treatment improving prognosis malignant tumor. Methods: Seven hundred sixty-five patients who had an operation for in department Obstetrics Gynecology Gachon University Gil Medical Center from April 2007 December 2009 were enrolled as subjects. A retrospective analysis age, parity, menopausal...