A5089050297- Plant Molecular Biology Research
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Light effects on plants
- Photosynthetic Processes and Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Circadian rhythm and melatonin
- Chronic Myeloid Leukemia Treatments
- Bone and Joint Diseases
- Retinopathy of Prematurity Studies
- Corneal surgery and disorders
- Congenital heart defects research
Korea Advanced Institute of Science and Technology
2018-2024
Seoul St. Mary's Hospital
2019-2022
Catholic University of Korea
2019-2022
Phytochrome B (phyB) inhibits the function of phytochrome-interacting factors (PIFs) by inducing their degradation and sequestration, but relative physiological importance these two phyB activities is unclear. In an analysis published Arabidopsis thaliana mutations, we identified a point mutation in N-terminal half (phyBG111D) that abolishes its PIF sequestration activity without affecting activity. We also C-terminal domain, which, when combined with deletion end (phyB990G767R), does...
Phytochrome-interacting factors (PIFs) are basic helix-loop-helix transcription that regulate light responses downstream of phytochromes. In Arabidopsis (Arabidopsis thaliana), 8 PIFs (PIF1-8) responses, either redundantly or distinctively. Distinctive roles may be attributed to differences in mRNA expression patterns governed by promoters variations molecular activities proteins. However, elements responsible for the functional diversification have yet determined. Here, we investigated role...
Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) includes heterogeneous conditions such as previous history and specific cytogenetic morphological properties. In this study, we analyze genetic aberrations using an RNA-based next-generation sequencing (NGS) panel assay in 45 patients AML-MRC detect 4 gene fusions of KMT2A-SEPT9, KMT2A-ELL, NUP98-NSD1, RUNX1-USP42 81 somatic mutations. Overall, all had comprising not only changes, but also We demonstrated several...
Lifelong treatment of pediatric chronic myeloid leukemia (CML) patients with tyrosine kinase inhibitors (TKIs) can affect their growth and development. For these reasons, clinical trials have explored the feasibility TKI discontinuation in children a sufficient response. We evaluated analytical performance digital droplet PCR (ddPCR) to quantify BCR-ABL1 compared results reverse transcription quantitative polymerase chain reaction (RT-qPCR). further investigated whether ddPCR could be used...
Corneal dystrophies (CDs) are a diverse group of inherited disorders with heterogeneous genetic background. Here, we report the identification novel ZNF143 heterozygous missense mutation in three individuals same family clinical and pathological features that consistent endothelial CD. Ophthalmologic examination revealed diffuse corneal clouding edema decreased cell density. Pathological findings showed increased thickness due to basal epithelial cells stroma, abnormal metaplastic...
Summary Juvenile myelomonocytic leukaemia (JMML), a rare clonal haematopoietic disorder of childhood, is characterised as myelodysplastic/myeloproliferative neoplasm. Despite ground‐breaking genetic discoveries, JMML remains difficult to diagnose given its diverse clinical features and disease course. A total 24 patients with were diagnosed treated at single institution, their profiles association laboratory characteristics analysed. In all, 22 the received allogeneic stem cell...