A5103135145- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Erythropoietin and Anemia Treatment
- Chronic Myeloid Leukemia Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Treatments and Mutations
- Antifungal resistance and susceptibility
- Erythrocyte Function and Pathophysiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Transplantation: Methods and Outcomes
- Biosimilars and Bioanalytical Methods
- Advancements in Transdermal Drug Delivery
- Child and Adolescent Psychosocial and Emotional Development
- Ultrasound in Clinical Applications
- Renal Transplantation Outcomes and Treatments
- Acute Lymphoblastic Leukemia research
- CNS Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Psychosocial Factors Impacting Youth
- Psychiatric care and mental health services
Kosin University
2019-2024
Kosin University Gospel Hospital
2017-2024
Kyung Hee University
2021
Jeju TechnoPark
2020
Biosolution (South Korea)
2020
Orygen Youth Health
2019
Ansan University
2018
Korea University
2018
Ajou University
2013
Abstract Background Transplantation-related mortality (TRM) is a major obstacle in allogeneic hematopoietic cell transplantation (allo-HCT). Approximately 60–80% of TRM occurs early, within 100 days transplantation. Methods This was nationwide population cohort study involving 5395 patients with acute leukemia who underwent allo-HCT between 2003 and 2015. Patient data were collected from the Korean National Health Insurance Service database. We investigated cumulative incidence rates (CIRs)...
Interim positron emission tomography/computed tomography (PET/CT) scan is a valuable tool for assessing the early metabolic response to chemotherapy in diffuse large B-cell lymphoma (DLBCL). Although radiotherapy an effective treatment lymphoma, especially local tumor control, role of consolidative (DLBCL) remains controversial. This study analyzed clinical outcomes patients with DLBCL treated rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), stratified by...
Abstract Post-transplant malignancy (PTM) is a leading cause of premature mortality among kidney transplantation recipients. However, population-based cohort studies that cover incidence, mortality, and risk factors for PTM are rarely reported, especially in East Asia. We designed retrospective study using national database. A total 9915 recipients between 2003 2016 were included. During this period, 598 cases (6.0%) de novo occurred. The most common was thyroid cancer (14.2%), followed by...
Abstract In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design new risk stratification system that combines the Revised International Staging System (R-ISS) FL, we analyzed data 380 patients newly diagnosed MM (NDMM) who underwent 18 F-fluorodeoxyglucose ( F-FDG) PET/CT upon diagnosis. The K-adaptive partitioning algorithm adopted define subgroups...
The epidemiological features of Waldenström macroglobulinemia (WM) have seldom been investigated at a national level, particularly in East Asia. goal our study is to present the incidence, prevalence, mortality, survival with competing risks, and causes death patients WM.
The role of allogeneic stem cell transplantation (alloSCT) in multiple myeloma (MM) treatment remains controversial. We conducted a retrospective, multicenter, nationwide study Korea to evaluate the outcomes alloSCT Asian patients with MM.
Erythropoiesis‐stimulating agents (ESAs), such as erythropoietin (EPO) and darbepoetin, may alleviate anemia in diffuse large B‐cell lymphoma (DLBCL) patients. However, many cancer cells express EPO receptors (EPOR), through which exogenously administered ESAs potentially promote cell growth. We conducted preclinical/phase II studies to investigate the safety efficacy of for managing chemotherapy‐related DLBCL examined EPOR expression germinal center (GCB)‐ activated (ABC)‐DLBCL lines,...
Clinicians and healthcare decision-makers conduct their clinical practice based on the results of trials. However, some health problems remain unresolved; in such cases, further research is required. To ensure reliable results, it important to understand study design well-designed Many designs can be chosen within two broad categories observational interventional. Clinical studies have a variety designs, including case series, case-control, cross-sectional, prospective retrospective cohort...
Abstract Several guidelines classify autologous stem cell transplantation (ASCT) as a low to intermediate risk group for infection. In nationwide population-based study, using the Korean Health Insurance Review and Assessment Service database, patients with lymphoma multiple myeloma (MM) who underwent ASCT from 2002 2016 were retrospectively analyzed. Cumulative incidence rates (CIRs) factors of opportunistic infections investigated. CIRs fungal, Varicella zoster virus (VZV), cytomegalovirus...
The International Myeloma Working Group has recently revised the diagnostic criteria for primary plasma cell leukemia (PCL) to circulating cells (CPCs) ≥ 5% in a peripheral blood smear. present study validated new patients with multiple myeloma or PCL diagnosed using previous criteria, who were administered immunomodulatory drugs proteasome inhibitors as induction therapy. We analyzed medical records of 1357 from eight hospitals South Korea. median age all was 64 years, and 187 (13.8%) had...
In this study, we examined the in vivo osteogenic differentiation of human embryoid bodies (hEBs) by using an injectable situ-forming hydrogel. A solution containing MPEG-b-(polycaprolactone-ran-polylactide) (MCL) and hEBs was easily prepared at room temperature. The MCL with factors injected into nude mice developed hydrogels injection sites; these maintained their shape even after 12 weeks vivo, thereby indicating that hydrogel a suitable scaffold for hEBs. observed only situ gel-forming...
The molecular features of mantle cell lymphoma (MCL), including its increased incidence, and complex therapies have not been investigated in detail, particularly East Asian populations. In this study, we performed targeted panel sequencing (TPS) whole-exome (WES) to investigate the genetic alterations Korean MCL patients. We obtained a total 53 samples from patients five university hospitals between 2009 2016. identified recurrently mutated genes such as SYNE1, ATM, KMT2D, CARD11, ANK2,...
Hyunji Choi, M.D., Sung ran Cho, Dahae Yang, Woonhyoung Lee, Hyunyong Hwang, Ho Sup Da Jung Kim, Taeyun and Mi Hyang M.D.. Ann Lab Med 2020;40:417-20. https://doi.org/10.3343/alm.2020.40.5.417
// Da Jung Kim 1 , Ho Sup Lee Joon-Ho Moon 2 Sang Kyun Sohn Hyeoung Joon 3 June-Won Cheong 4 Deog-Yeon Jo 5 Hawk 6 Hyewon 7 Soo-Mee Bang 8 Won Sik 9 Yong Park 10 Mark Hong 11 Jae Hoon 12 Sung Hwa Bae 13 Min Kyoung 14 and The Korean Society of Hematology AML/MDS Working Party Department Internal Medicine, Kosin University College Gospel Hospital, Busan, South Korea Hematology/Oncology, Kyungpook National Daegu, Hematology-Oncology, Chonnam Hwasun Hwasun, Jeollanamdo, Yonsei Seoul, Chungnam...
7066 Background: Despite advanced treatments, including chimeric antigen receptor therapy (CAR-T), a significant proportion of patients succumb to relapsed and refractory diffuse large B cell lymphoma (R/R DLBCL). In vitro experiments suggest synergism between BTK inhibitor (BTKi) T-cell engager, we initiated multicenter trial poseltinib glofitamab in combination with lenalidomide R/R DLBCL. Methods: This is phase II, open label, single arm study aiming enroll 76 participants adult DLBCL...
Mortality at an early stage after kidney transplantation is a catastrophic event. Treatment-related mortality (TRM) within 1 or 3 months has been seldom reported. We designed retrospective observational cohort study using national population-based database, which included information about all recipients between 2003 and 2016. A total of 16,073 patients who underwent were included. The rates month (early TRM) 0.5% (n = 74) 1.0% 160), respectively. Based on multivariate analysis, older age...
CT-P10 was the first licensed rituximab biosimilar. This Korean post-marketing surveillance study evaluated safety and effectiveness in approved indications.This prospective, open-label, observational, phase 4 collected routine clinical practice data across 27 centers Republic of Korea. Patients received their treatment, per prescribing information, for non-Hodgkin's lymphoma (NHL), chronic lymphocytic leukemia (CLL), rheumatoid arthritis (RA), granulomatosis with polyangiitis (GPA), or...
Abstract Background Allergic diseases have a high incidence in childhood and chance to be carried over into adulthood unless appropriately treated during childhood, it is important that healthcare providers actively manage these diseases. This study was identify multidimensional factors affect weight gain preschool children with allergic Methods The overweight obesity prediction model for analyzed using multiple logistic regression analysis decision tree the present secondary data used from...
e19538 Background: Erythropoiesis-stimulating agents (ESAs), such as erythropoietin (EPO) and novel erythropoiesis stimulating protein (NESP), may alleviate anemia in diffuse large B-cell lymphoma (DLBCL) patients. However, many cancer cells express EPO receptors (EPOR), through which exogenously-administered ESAs potentially promote cell growth. We conducted preclinical/phase II studies to investigate the safety efficacy of for managing chemotherapy-related DLBCL Methods: examined EPOR...
Objective: To compare correlations between pulmonary function test (PFT) results and different reconstruction algorithms to suggest the optimal protocol for computed tomography (CT) quantification of low lung attenuation areas airways in healthy individuals.Materials Methods: A total 259 subjects with normal PFT chest CT were included.CT scans reconstructed using filtered back projection, hybrid-iterative reconstruction, model-based IR (MIR).For quantitative analysis, emphysema index (EI)...
This letter is intended to clarify the clinical effectiveness of neuropeptide substance P (SP) in reducing age-related skin wrinkling. first study evaluate efficacy topical application SP on wrinkle reduction. For study, we tested a stable formulation known as SP-based hydrogel against aging participants. We found that this reduced based changes observed several cutaneous parameters.