A5056036060- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Erythrocyte Function and Pathophysiology
- Blood Coagulation and Thrombosis Mechanisms
- Antibiotic Resistance in Bacteria
- Hemoglobinopathies and Related Disorders
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Prenatal Screening and Diagnostics
- Diphtheria, Corynebacterium, and Tetanus
- Genomic variations and chromosomal abnormalities
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Blood properties and coagulation
- Infectious Diseases and Tuberculosis
- Mesenchymal stem cell research
- Pharmaceutical and Antibiotic Environmental Impacts
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Animal Virus Infections Studies
- Caveolin-1 and cellular processes
Chungnam National University
2015-2024
Chungnam National University Hospital
2019-2022
Dankook University Hospital
2016-2018
Dankook University
2018
Seoul National University
2009-2015
Background: Dysfunctional natural anticoagulant systems enhance intravascular fibrin formation in disseminated coagulation (DIC), and plasma levels of anticoagulants can be used the diagnosis prognosis DIC.Herein, diagnostic value 4 was assessed, prognostic antithrombin protein C were validated a large population.Methods: Part 1 study included 126 patients with clinically suspected DIC estimated candidate proteins: antithrombin, C, S, Z. 2 comprised 1,846 patients, whom compared other...
Abstract Background The emergence and transmission of tigecycline‐ carbapenem‐resistant Klebsiella pneumoniae (TCRKP) have become a major concern to public health globally. Here, we investigated the molecular epidemiology mechanisms tigecycline resistance in K (CRKP) isolates. Methods Forty‐five non‐duplicate CRKP isolates were collected from January 2017 June 2019. We performed antimicrobial susceptibility tests, multilocus sequence typing (MLST), pulsed‐field gel electrophoresis (PFGE)....
Current diagnostic tests for hereditary spherocytosis (HS) focus on the detection of hemolysis or indirectly assessing defects membrane protein, whereas direct methods to detect protein are complicated and difficult implement. In present study, we investigated patterns genetic variation associated with HS among patients clinically diagnosed HS. Multi-gene targeted sequencing 43 genes (17 RBC protein-encoding genes, 20 enzyme-encoding six additional differential diagnosis) was performed using...
Cytogenetic testing is important to ensure patient safety before therapeutic application of mesenchymal stromal cells (MSCs). However, the standardized methods and criteria for screening chromosomal abnormalities MSCs have not yet been determined. We investigated frequency cytogenetic aberrations in using G-banding fluorescence situ hybridization (FISH) suggest reference values aneuploidy MSCs. analysis was performed on 103 consecutive cultures from 68 (25 adipose-origin, 20 bone...
Abstract Background The emergence of carbapenem‐resistant Escherichia coli (E coli) is a serious global health threat, but little known about carbapenemase‐producing E in Daejeon, South Korea. aim this study was to investigate characteristics thirteen isolates tertiary hospital. Methods Thirteen non‐duplicate strains were collected from October 2017 January 2018. Antimicrobial susceptibility determined with the test or disk diffusion method. carbapenem minimum inhibitory concentrations...
Abstract Background The various virulence factors of methicillin‐resistant Staphylococcus aureus bacteremia (MRSAB) are associated with a high mortality rate worldwide. Further studies warranted to confirm the significant relationship between strains and genes. Here, we prospectively investigated molecular characteristics underlying genotypes MRSA isolated from patients bacteremia. Methods We collected 59 isolates adult Antimicrobial susceptibility results were obtained Vitek2 automated...
Crystal-storing histiocytosis (CSH) is an uncommon finding in plasma cell neoplasms. CSH thought to be intralysosomal deposition of secreted paraproteins or immunoglobulins, which usually express κ immunoglobulin light chains that finally aggregate crystals. Because its rarity, bone marrow often makes diagnosis difficult.A 57-year-old woman had IgA monoclonal proteinemia and proteinuria. In the aspirate, cells were initially counted less than what would expected, whereas histiocytes with...
Shinae Yu, M.D., Byung Ryul Jeon, Ph.D., Changseung Liu, Dokyun Kim, Hae-Il Park, Hyung Doo Jeong Hwan Shin, Jun Lee, Qute Choi, Sollip Yeo Min Yun, and Eun-Jung Cho, Ph.D.; On behalf of the Evidence-Based Laboratory Medicine Committee Korean Society for Medicine. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0111
The FilmArray Respiratory Panel RP 2.1 plus (FilmArray RP) is a point-of-care syndromic panel for respiratory pathogens. Although highly valuable in the clinical settings, co-detection of pathogens may confound result interpretation.
The cytogenetic analysis of mesenchymal stromal cells (MSCs) is essential for verifying the safety and stability MSCs. An in situ technique, which uses grown on coverslips karyotyping minimizes cell manipulation, standard protocol chromosome amniotic fluids. Therefore, we applied technique MSCs compared quality metaphases results with classical G-banding chromosomal abnormalities fluorescence hybridization (FISH). Human adipose- umbilical cord-derived MSC lines (American Type Culture...
Abstract As ABO blood type influences the plasma level of coagulation factor VIII (FVIII), it likely also affects activated partial thromboplastin time (aPTT) and thrombin generation assay (TGA) values. Here, we aimed to investigate effect on normal values three global assays: prothrombin (PT), aPTT, TGA. PT, TGA [1 or 5 pmol/L tissue (TF)], factors, anticoagulation were measured in 200 healthy adults. aPTT was significantly prolonged those with O compared non-O, whereas PT not different...
Background The process of plate streaking has been automated to improve routine workflow clinical microbiology laboratories. Although there were many evaluation reports about the inoculation various body fluid samples, few evaluations have reported for blood. In this study, we evaluated performance inoculating system, Previ Isola samples including Methods Blood culture, fluid, and urine collected. All inoculated on both sheep blood agar ( BAP ) MacConkey MCK using manual method. We compared...
Waldenström macroglobulinemia (WM) is a malignant lymphoplasma-proliferative disorder with IgM monoclonal gammopathy. A recent whole-genome study identified MYD88 L265P as the key mutation in WM. We investigated mutations conjunction cytogenetic 22 consecutive Korean WM patients. Conventional G-banding and interphase fluorescence situ hybridization (FISH) were performed at regions including 6q21 using bone marrow (BM) aspirates. Sixteen patients subjected to Sanger sequencing-based study....
Real-time (RT) PCR is a rapid and accurate method that widely used for the detection of Mycobacterium tuberculosis complex (MTB). The aim this study was to evaluate compare performance Genedia MTB/NTM Detection Kit Anyplex plus kit in MTB nontuberculous mycobacteria (NTM) clinical specimens.From October 2017 February 2018, 236 respiratory specimens 137 non-respiratory specimens, from patients with suspected tuberculosis, were examined. AFB smear, culture, RT-PCR using (Green Cross Medical...
To characterise the antibody response for 12 weeks following second dose of Pfizer/BioNTech BNT162b2 mRNA vaccine in hospital workers a Korean general hospital. We measured level severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) anti-receptor binding domain (anti-RBD) and neutralising antibodies every week first 4 weeks, at 8 vaccination 71 workers. The initial median anti-RBD were 3898.0 U/mL (interquartile range [IQR], 2107.5–5478.5) 97.54 % (IQR, 96.85–97.81), respectively....
Hyun Jin Kim, M.D., Ph.D., Manmyung Hyunjae Zhang, M.E., Hae Ri Jae Wan Jeon, Yuri Seo, and Qute Choi, Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0304
A 54-year-old woman was admitted with compression fracture of thoracic vertebral bodies.Urine protein electrophoresis revealed the presence M and serum free κ/λ ratio 0.01.Bone marrow aspiration (A) biopsy (B) diffuse infiltration numerous large-sized blasts basophilic cytoplasm, dispersed nuclear chromatin, high nuclear/cytoplasmic prominent nucleoli.Tumor cells showed strong expression plasma cell (PC) antigen CD138 (C), monotypic light chain (D, κ negative; E, λ positive), negative CD3,...
Background Tuberculosis ( TB ) is an infectious disease caused by the bacillus Mycobacterium tuberculosis MTB ); it transmitted among people through air. The aim of this study was to assess prevalence and its clinical trends collecting analyzing data on specimens in Korea. Methods All referred Dankook University Hospital Laboratory Cheonan, Korea, from September 2005 June 2016 were tested isolate using solid liquid cultures, acid‐fast bacilli AFB smears, polymerase chain reactions PCR )....
Mycobacterium tuberculosis (MTB) causes (TB), which is a fatal disease. Cases of drug-resistant MTB have increased in recent years. In this study, we analyzed 7 sites DNA sequences, including the rpoB and inhA gene, to investigate relationship between gene mutations drug resistance MTB.Mycobacterium liquid culture samples (197 specimens from 74 cases) were collected June 2015 May 2016 sequenced. The results compared with those obtained antibiotic susceptibility tests.In 65 (87.8%) cases,...
Purpose: Refractory Mycoplasma pneumonia (RMP) has been increasing not only in Korea but worldwide. We investigated the inci dence of M. resistant to macrolides and risk factors for RMP. Methods: From October 2015 May 2016, 62 pediatric patients who were admitted due diagnosed on basis chest x-ray with respiratory symptoms positive pneumoniae polymerase chain reaction no evidence other bac terial or viral infections included. Sequence analysis 23S rRNA gene was performed identify macro lide...