A5060440981- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Reproductive tract infections research
- Enterobacteriaceae and Cronobacter Research
- Urinary Tract Infections Management
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Bacterial biofilms and quorum sensing
- Mycobacterium research and diagnosis
- Pharmaceutical and Antibiotic Environmental Impacts
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Biosensors and Analytical Detection
- Antibiotics Pharmacokinetics and Efficacy
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Syphilis Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Vibrio bacteria research studies
- Infective Endocarditis Diagnosis and Management
- Pneumonia and Respiratory Infections
Yonsei University
2015-2024
Seoul National University Hospital
2015-2024
Severance Hospital
2019-2024
Gangnam Severance Hospital
2024
Seoul St. Mary's Hospital
2023
Korea Disease Control and Prevention Agency
2020-2022
National Health Insurance Service
2022
National Health Insurance Service Ilsan Hospital
2022
Yonsei University Health System
2021
University Medical Center
2021
Abstract: A new approach is presented for health monitoring of structures using terrestrial laser scanning (TLS). Three‐dimensional (3D) coordinates a target structure acquired TLS can have maximum errors about 10 mm, which insufficient the purpose structures. displacement measurement model to improve accuracy measurement. The tested experimentally on simply supported steel beam. Measurements were made three different techniques: (1) linear variable transducers (LVDTs), (2) electric strain...
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 not yet has established its treatment, but convalescent plasma been expected to increase survival rates as in the case with other emerging viral infections.We describe two cases of COVID-19 treated infusion.Both patients presented pneumonia distress and showed a favorable outcome after use addition systemic corticosteroid.To our knowledge, this is first report therapy for Korea.
ABSTRACT Carbapenem resistance mediated by acquired carbapenemase genes has been increasingly reported, particularly for clinical isolates of Pseudomonas aeruginosa and Acinetobacter spp. Of 1,234 nonduplicate carbapenem-resistant isolated at a tertiary-care hospital in Seoul, Korea, 211 (17%) were positive metallo-β-lactamase (MBL). these, 204 (96%) had either the bla IMP-1 or VIM-2 allele. In addition, seven baumannii found to have novel MBL gene, which was designated SIM-1 . The protein...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over forty million patients worldwide. Although most disease 2019 (COVID-19) have a good prognosis, some develop illness. Markers that define severity or predict clinical outcome need to be urgently developed as the mortality rate in critical cases is approximately 61.5%. In present study, we performed in-depth proteome profiling of undepleted plasma from eight COVID-19 patients. Quantitative proteomic analysis...
National surveillance of antimicrobial resistance becomes more important for the control and determination treatment guidelines. We analyzed Korean Antimicrobial Resistance Monitoring System (KARMS) data collected from 2013 to 2015.Of KARMS participants, 16 secondary or tertiary hospitals consecutively reported rates 2015. Data duplicate isolates institutions with fewer than 20 were excluded. To determine long-term trends, previous 2004 2012 also considered.The prevalence...
To examine mutations within the penA, mtrR, porB, ponA and pilQ genes of Neisseria gonorrhoeae to determine their contribution cephalosporin resistance. A total 46 N. isolates with reduced susceptibility cefixime or ceftriaxone (MICs ≥ 0.12 mg/L) two susceptible were selected. The full sequence penA partial sequences previously reported as hot mutation sites other analysed. Genotyping by multiantigen typing (NG-MAST) was also performed. mosaic penicillin-binding protein 2 (PBP 2) found in a...
The Korean government established an antimicrobial resistance (AMR) surveillance system, compatible with the Global AMR Surveillance System (GLASS): Kor-GLASS. We describe results from first year of operation Kor-GLASS May 2016 to April 2017, comprising all non-duplicated clinical isolates major pathogens blood, urine, faeces and urethral cervical swabs six sentinel hospitals. Antimicrobial susceptibility tests were carried out by disk diffusion, Etest, broth microdilution agar dilution...
A total of 431 Pseudomonas aeruginosa clinical isolates were collected from 29 general hospitals in South Korea 2015. Antimicrobial susceptibility was tested by the disk diffusion method, and MICs carbapenems determined agar dilution method. Carbapenemase genes amplified PCR sequenced, structures class 1 integrons surrounding carbapenemase gene cassettes analyzed mapping. Multilocus sequence typing (MLST) pulsed-field gel electrophoresis (PFGE) performed for strain typing. Whole-genome...
To investigate the risk factors of patients with Klebsiella pneumoniae (KP) bloodstream infection (BSI) a focus on antimicrobial resistance and virulence factors. All KP BSI (n = 579) from six general hospitals during 1 year period were included in this study. The hosts causative isolates assessed to determine associations 30 day mortality by multivariate Cox hazards modelling. rate was 16.9% (98/579). Among host-associated factors, increased SOFA score leucopenia status exhibited strong...
External quality assessment (EQA) is essential for ensuring reliable test results, especially when laboratories are using assays authorized emergency use newly emerging pathogens. We developed an EQA panel to assess the of real-time reverse transcription PCR being used in South Korea detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With participation 23 public health organization and 95 nongovernmental involved SARS-CoV-2 testing, we conducted qualitative semiquantitative...
Background & Aims Fusobacterium nucleatum (FN) plays a pivotal role in the development and progression of colorectal cancer by modulating antitumor immune responses. However, impact FN on regulation tumor microenvironment has not been fully elucidated. Methods The abundance was measured 99 stage III CRC tissues using quantitative polymerase chain reaction. Gene expression profiles were assessed annotated consensus molecular subtypes (CMS), Ontology (GO) analysis, deconvolution...
This study was performed to assess the prevalence and genotypes of plasmid-borne extended-spectrum beta-lactamases (ESBLs) AmpC in Escherichia coli Korea. A total 576 isolates E. collected from 12 Korean hospitals during May July 2007. phenotypic confirmatory test detected ESBLs 82 (14.2 %) isolates. The most common types identified were CTX-M-14 (n=32) CTX-M-15 (n=27). diversity CTX-M mutants, including CTX-M-15, CTX-M-27 CTX-M-57, with significant hydrolytic activity against ceftazidime...
Heejung Kim, M.D., Seok Hoon Jeong, Kyoung Ho Roh, Seong Geun Hong, Jong Wan Myung-Geun Shin, Mi-Na Hee Bong Young Uh, Hyukmin Lee, Kyungwon M.D.. Korean J Lab Med 2010;30:491-7. https://doi.org/10.3343/kjlm.2010.30.5.491
To assess the epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in South Korea.From 2011 to 2015, 2487 carbapenem-nonsusceptible were collected through Korean National Laboratory Surveillance System. Disk-diffusion for antimicrobial susceptibility, PCR/sequencing detect carbapenemase genes and multilocus sequence typing molecular carried out.The number was increasing approximately 1.5-fold per year proportion CPEs exponentially confirmed from 2014. KPC most dominant, mostly...
This study was carried out to investigate the epidemiological time-course of New Delhi metallo-beta-lactamase- (NDM-) mediated carbapenem resistance in Enterobacteriaceae South Korea. A total 146 non-duplicate NDM-producing recovered between 2010 and 2015 were voluntarily collected from 33 general hospitals confirmed by PCR. The species identified sequences 16S rDNA. Antimicrobial susceptibility determined either disk diffusion method or broth microdilution, MICs agar dilution. Then,...
High rates of carbapenem resistance in the human pathogen Acinetobacter baumannii threaten public health and need to be scrutinized.A total 356 A. 50 non-baumannii spp. (NBA) strains collected 2013 throughout South Korea were studied. The type blaOXA-23 transposon was determined by PCR mapping molecular epidemiology assessed MLST. Twelve representative two comparative entirely sequenced single-molecule real-time sequencing.The rate 88% baumannii, mainly due blaOXA-23, with five exceptional...
Abstract Background Choosing the specimen type is first step of pre-analytical process. Previous reports suggested plasma as optimal for circulating tumor DNA (ctDNA) analysis. However, head-to-head comparisons between and serum using platforms with high analytical sensitivity, such droplet digital polymerase chain reaction (ddPCR), are limited, several recent studies have supported clinical utility serum-derived ctDNA. This study aimed to compare profiles isolated from serum, characterize...
Abstract Introduction: The assessment of bone marrow thrombopoietic activity in patients with thrombocytopenia is necessary to achieve an accurate diagnosis and administer effective treatment. We evaluated the discriminatory power immature platelet fraction (IPF) differentiating hyperdestructive/consumptive from hypoproductive its potential use as a predictive marker for recovery. Methods: In this observational study, indices, including IPF, were measured 105 healthy individuals, 27 (all...
Heungsup Sung, M.D., Kyoung Ho Roh, Ki Hong, Moon-Woo Seong, Namhee Ryoo , Hyun Soo Kim, Jaehyeon Lee, So Yeon Sookwon Yoo, Mi-Na Myung Guk Han, D.V.M., Sang Won Ph.D., Hyukmin and Cheon Kwon Ph.D.; on behalf of COVID-19 Diagnosis Test Management Committee established by Korea Centers for Disease Control Prevention. Ann Lab Med 2020;40:439-47. https://doi.org/10.3343/alm.2020.40.6.439