A5035321665- Seismology and Earthquake Studies
- earthquake and tectonic studies
- Seismic Waves and Analysis
- High-pressure geophysics and materials
- Geological and Geochemical Analysis
- Catalytic C–H Functionalization Methods
- Seismic Imaging and Inversion Techniques
- Geological Modeling and Analysis
- Glycosylation and Glycoproteins Research
- Asymmetric Hydrogenation and Catalysis
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Chemical Reaction Mechanisms
- Receptor Mechanisms and Signaling
- Trypanosoma species research and implications
- Reservoir Engineering and Simulation Methods
- Catalytic Cross-Coupling Reactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Meteorological Phenomena and Simulations
- Spacecraft Design and Technology
- Neurotransmitter Receptor Influence on Behavior
- Bacterial Genetics and Biotechnology
- Synthesis and Catalytic Reactions
- Earthquake Detection and Analysis
Arizona State University
2024
EarthScope Consortium
2023
Institute for Radiological Image Sciences
2019-2021
Incorporated Research Institutions For Seismology
2008-2020
University of Mount Union
2013-2019
AstraZeneca (United Kingdom)
2005-2018
Macclesfield College
2015-2016
The Ohio State University
2007-2011
Harvard University
1991-2011
Planetary Science Institute
1991-2011
We obtain a three‐dimensional (3D) model of shear wave velocity heterogeneity the Earth's mantle by inverting large set seismic data consisting 27,000 long‐period seismograms and 14,000 travel time observations. About 60% has been collected through efforts several research groups used in earlier studies. The new data, which come from stations different networks including Chinese Digital Seismographic Network (CDSN) Geoscope, are extracted to provide sampling as uniform possible. Because...
Epigenetic mechanisms of gene regulation have a profound role in normal development and disease processes. An integral part this mechanism occurs through lysine acetylation histone tails which are recognized by bromodomains. While the biological structural characterization many bromodomain containing proteins has advanced considerably, therapeutic tractability protein family is only now becoming understood. This paper describes discovery molecular potent (nM) small molecule inhibitors that...
ABSTRACT We have used irnmunofluorescent detection of 5-bromo-2-deoxyuridine-substituted DNA in order to determine the timing initiation and duration nuclear kinetoplast S-phases within procyclic stage Trypanosoma brucei cell cycle. Both were shown be periodic, occupying 0.18 0.12 unit cycle, respectively. In addition, both these approximate synchrony, differing by only 0.03 also a monoclonal antibody that recognises basal bodies T. visualise cells possessing new pro-basal body hence time...
We have made over ten thousand measurements of PP ‐ P and SS S differential travel times from long‐period Global Digital Seismograph Network recordings all events with m b ≥ 5.5 which occurred during the years 1976 to 1986. obtained reasonable global coverage, very good sampling several regions world. The residuals range −5 5 s for −12 12 reveal a large‐scale pattern heterogeneity when plotted at reflected phase's bounce point. Our experiments indicate that lower‐mantle structure...
An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) reaction monitoring and product quantification, is presented.
Self-optimising flow reactors combine online analysis with evolutionary feedback algorithms to rapidly achieve optimum conditions.
The seismic models of three‐dimensional (3‐D) mantle heterogeneity may be interpreted in terms the density perturbations which drive flow and thus provide important predictions flow‐related observables, such as nonhydrostatic geoid. current global‐scale shear velocity reasonably good fits to long‐wavelength geoid data (60–70% variance reductions) but rather poor corresponding free‐air gravity anomalies (30–40% reductions). This major difference is due two factors: (1) very different...
The very long wavelength (i.e. in the degree range ℓ = 1–8) dynamic topography at Earth's surface, estimated by isostatic reduction of observed topography, is shown to be good agreement with predicted a model viscous flow mantle. This was previously derived independent consideration nonhydrostatic geoid and based upon recent large‐scale seismic shear velocity heterogeneity Our estimate (and prediction) surface reveals significant depressions (≈ 2–3 km) continental shields relative their...
Top of the P-O-Ps: Stabilization a cationic rhodium catalyst with hemilabile P-O-P ligand dpephos allows efficient intermolecular hydroacylation challenging substrates (see scheme). Structural studies have established role coordination oxygen atom, and catalytically competent acyl–hydridorhodium intermediate was fully characterized.
Neisseria meningitidis PglL belongs to a novel family of bacterial oligosaccharyltransferases (OTases) responsible for O-glycosylation type IV pilins. Although members this are widespread among pathogenic bacteria, there is little known about their mechanism. Understanding the process may uncover potential targets therapeutic intervention, and can open new avenues exploitation these pathways biotechnological purposes. In work, we demonstrate that able transfer virtually any glycan from...
The development of a continuous flow process for asymmetric hydrogenation with heterogenized molecular catalyst in real industrial context is reported. key step the synthesis an API (active pharmaceutical ingredient) has been developed on kilogram scale constant high single-pass conversion (>95.0%) and enantioselectivity (>98.6% ee) through corresponding enamide. This performance was achieved using commercially available chiral (Rh/(S,S)-EthylDuphos) immobilized solid support via strong...
Abstract The Europa Thermal Emission Imaging System (E-THEMIS) on the Clipper spacecraft will investigate temperature and physical properties of using thermal infrared (TIR) images in three wavelength bands centered from 7-14 μm, 14-28 μm 28-80 μm. E-THEMIS map >80% surface at multiple times day a resolution 8-km per pixel, ∼32% percent ≤1 km/pixel resolution, ∼6% ≤100 m/pixel resolution. specific objectives investigation are to 1) understand formation features, including sites recent or...
Histone deacetylase inhibitors (HDACi) are a relatively new class of chemotherapy agents. Herein, we report click-chemistry based approach to the synthesis HDACi. Fourteen agents were synthesized from combination two alkyne and seven azido precursors. The inhibition HDAC1 HDAC8 was then determined by in vitro enzymatic assays, after which cytotoxicity evaluated NCI human cancer cell line screen. A lead compound 5g (NSC746457) discovered that inhibited at an IC50 value 104 ± 30 nM proved...
The power of palladium: total synthesis the alkaloid hodgkinsine B has been achieved with just six isolated intermediates and only four chromatographic operations. route involves a palladium-catalyzed enantioselective desymmetrizing N-allylation meso- chimonanthine to establish absolute configuration elaboration desymmetrized core by diastereoselective α-oxindole arylation.
A continuous Buchwald–Hartwig reaction using the bulky N-heterocyclic carbene (NHC) precatalyst [Pd(IPr*)(cin)Cl] 4 has been developed for synthesis of a key pharmaceutical intermediate 2. Using microreactor technology, could be optimized under dilute conditions with low material burden and kinetic parameters investigated. For larger lab-scale operation (gram scale), process-relevant concentrations employed workup effectively demonstrated (batch methodology published concurrently). The...
o-Halo benzoates can be combined with monoalkyl ureas in a tandem palladium-catalyzed arylation−ester amidation sequence to deliver quinazolinedione products. The reactions are regioselective for formation of the 3-N-alkyl isomers. Significant variation both coupling partners is possible, allowing synthesis diverse array substituted quinazolinediones, exemplified by preparation simple unsymmetric-dialkylated natural product.
[reaction: see text]. Beta-thioacetal-substituted aldehydes, which are conveniently prepared from the corresponding ynals, can be combined with a range of alkynes or electron-poor alkenes to deliver intermolecular hydroacylation adducts. The reactions employ [Rh(dppe)]ClO4 as catalyst and proposed proceed via chelated rhodium acyl intermediate. thioacetal-containing products deprotected ketones reduced alkanes in good yields.
The use of β-S-substituted aldehydes in rhodium-catalyzed intermolecular hydroacylation reactions is reported. Aldehydes substituted with either sulfide or thioacetal groups undergo efficient a variety electron-poor alkenes, such as enoates, Stetter-like processes and both neutral alkynes. In general, the alkenes demonstrate good selectivity for linear regioisomer, alkynes provide enone products excellent E-isomers. scope process was shown to be broad, tolerating substitution patterns...