A5006490641- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Nanowire Synthesis and Applications
- 2D Materials and Applications
- T-cell and B-cell Immunology
- Semiconductor materials and devices
- Nanofabrication and Lithography Techniques
- Glass properties and applications
- Silicon Nanostructures and Photoluminescence
- Advancements in Photolithography Techniques
- Nonlinear Optical Materials Studies
- Chalcogenide Semiconductor Thin Films
- Gold and Silver Nanoparticles Synthesis and Applications
- Iron-based superconductors research
- Photorefractive and Nonlinear Optics
- Topological Materials and Phenomena
- Quantum Dots Synthesis And Properties
- Water Quality Monitoring and Analysis
- Cancer Immunotherapy and Biomarkers
- Electrochemical Analysis and Applications
- Metalloenzymes and iron-sulfur proteins
- Ion-surface interactions and analysis
- Diamond and Carbon-based Materials Research
- Virus-based gene therapy research
University of California, Los Angeles
1991-2024
University of California, Riverside
2021-2024
Abstract Cancer immunotherapy with autologous chimeric antigen receptor (CAR) T cells faces challenges in manufacturing and patient selection that could be avoided by using ‘off-the-shelf’ products, such as allogeneic CAR natural killer ( Allo CAR-NKT) cells. Previously, we reported a system for differentiating human hematopoietic stem progenitor into CAR-NKT cells, but the use of three-dimensional culture xenogeneic feeders precluded its clinical application. Here describe clinically guided...
The field of T cell-based and chimeric antigen receptor (CAR)-engineered (CAR-T) antitumor immunotherapy has seen substantial developments in the past decade; however, considerable issues, such as graft-versus-host disease (GvHD) tumor-associated immunosuppression, have proven to be roadblocks widespread adoption implementation. Recent innate immune CAR therapy opened several doors for expansion this therapy, especially it relates allogeneic cell sources solid tumor infiltration. This study...
The intricate microenvironment in which malignant cells reside is essential for the progression of tumor growth. Both physical and biochemical features (TME) play a critical role promoting differentiation, proliferation, invasion, metastasis cancer cells. It therefore to understand how interact communicate with an assortment supportive tumor-associated including macrophages, fibroblasts, endothelial cells, other immune To study complex mechanisms behind progression, 3D spheroid organoid...
Tumor-associated macrophages (TAMs) accumulate in the solid tumor microenvironment (TME) and have been shown to promote growth dampen antitumor immune responses. TAM-mediated suppression of T-cell reactivity is considered be a major obstacle for many immunotherapies, including checkpoint blockade adoptive T/CAR-T-cell therapies. An ex vivo culture system closely mimicking TME can greatly facilitate study cancer immunotherapies. Here, we report development 3D TME-mimicry that comprised three...
Ovarian cancer (OC) is highly lethal due to late detection and frequent recurrence. Initial treatments, comprising surgery chemotherapy, lead disease remission but are invariably associated with subsequent relapse. The identification of novel therapies an improved understanding the molecular cellular characteristics OC urgently needed. Here, we conducted a comprehensive analysis primary tumor cells their microenvironment from 16 chemonaive 10 recurrent patient samples. Profiling biomarkers...
Photoluminescence excitation (PLE) measurements allow one to obtain direct information on the absorption processes in porous Si leading strong visible luminescence which has recently been reported. This technique does not need a free-standing sample, but effect of layer thickness should be included interpretation PLE data. In our spectra, two separate edges are observed and initial shifts higher energies with storage time. The trends these changes consistent quantum wire model.
Invariant natural killer T (iNKT) cells have the capacity to mount potent anti-tumor reactivity and therefore become a focus in development of cell-based immunotherapy. iNKT attack tumor using multiple mechanisms with high efficacy; however, their clinical application has been limited because low numbers cancer patients difficulties infiltrating solid tumors. In this study, we aimed overcome these critical limitations by α-GalCer, synthetic glycolipid ligand specifically activating cells,...
Fluorescent nanodiamonds (FNDs) with nitrogen-vacancy centers are pivotal for advancing quantum photonics and imaging through deterministic state manipulation. However, integration of emitters into photonic devices remains a challenge due to the need high coupling efficiency Purcell enhancement. We report FND-integrated nanofocusing device achieved by assembling FNDs at plasmonic waveguide tip plasmonic-enhanced optical trapping. This technique not only increases emission rate 58.6 times...
Interlayer excitons, or bound electron–hole pairs whose constituent quasiparticles are located in distinct stacked semiconducting layers, being intensively studied heterobilayers of two-dimensional semiconductors. They owe their existence to an intrinsic type-II band alignment between both layers that convert these into p–n junctions. Here, we unveil a pronounced interlayer exciton (IX) metal monochalcogenides, namely, γ-InSe on ε-GaSe, emission is adjustable just by varying thicknesses...
In this presentation we share how the development of step-and-repeat DTL technology is addressing growing need for periodic patterning in large-area device fabrication display, AR/VR, and other photonic applications with low-cost, high-throughput (+40wph), high-resolution (UV, DUV) capabilities. Like projection lithography, non-contact, optical very repeatable a particle controlled mini-environment, robust to defectivity. Unlike projection, image not limited small depth focus (DOF). High...
The photonic device market has a need for low‐cost, high‐resolution periodic patterning that scales with product maturity to large substrate sizes. Eulitha's DTL (Displacement Talbot Lithography) technology was limited only single exposure field per on preexisting platforms which can fully pattern 100 and 150mm substrates. new ‘PhableS' is step‐and‐repeat solution bring all the advantages of larger PhableS tool builds patented displacement lithography open way customers scale high volume...
Organically modified silicates (Ormosils) have been applied as matrices in the preparation of CdS-doped glassy nanocomposites via a low temperature route. EDX spectra show that CdS concentration up to about 20 wt.% has obtained. The microcrystallites hexagonal wurtzite structure with average particle size range 120 angstroms were formed within Ormosils matrices. quantum confinement effects clearly observed samples smaller sizes from absorption and photoluminescence excitation spectra. High-...