A5102789698- Circadian rhythm and melatonin
- Plant and animal studies
- Neurobiology and Insect Physiology Research
- CAR-T cell therapy research
- Insect Resistance and Genetics
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- Plant biochemistry and biosynthesis
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Magnetic and Electromagnetic Effects
- Chronic Myeloid Leukemia Treatments
- Digestive system and related health
- Neurotransmitter Receptor Influence on Behavior
- Genetic diversity and population structure
- Virus-based gene therapy research
- Cannabis and Cannabinoid Research
- Acute Myeloid Leukemia Research
- Genomics and Phylogenetic Studies
University of California, Los Angeles
2023-2025
Broad Center
2023-2025
University of California, Berkeley
2019-2023
University of California, Davis
2020
Grinnell College
2007
Children's Hospital of Los Angeles
2007
Human fallopian tubes are intrinsic to reproduction. The purpose of the is allow for transit sperm, ovum, and if fertilization successful, embryo. epithelial cells that line inner surface integral both normal abnormal tube processes, including disease initiation. After menopause, cease have a significant role in body intraepithelial cell makeup changes. We describe method which these can be isolated from fresh with minimal stromal contamination into single-cell suspension. These grown...
Abstract Endocannabinoids (eCBs) inhibit neurotransmitter release throughout the central nervous system. Using Ceratomandibularis muscle from lizard Anolis carolinensis we asked whether eCBs play a similar role at vertebrate neuromuscular junction. We report here that CB 1 cannabinoid receptor is concentrated on motor terminals and mediate inhibition of induced by activation M 3 muscarinic acetylcholine (ACh) receptors. N...
Ovarian cancer (OC) is highly lethal due to late detection and frequent recurrence. Initial treatments, comprising surgery chemotherapy, lead disease remission but are invariably associated with subsequent relapse. The identification of novel therapies an improved understanding the molecular cellular characteristics OC urgently needed. Here, we conducted a comprehensive analysis primary tumor cells their microenvironment from 16 chemonaive 10 recurrent patient samples. Profiling biomarkers...
ABSTRACT One-quarter of extant Eukaryotic species are herbivorous insects, yet the genomic basis this extraordinary adaptive radiation is unclear. Recently-derived hold promise for understanding how colonization living plant tissues shaped evolution herbivore genomes. Here, we characterized exceptional patterns coupled with a recent (<15 mya) transition to herbivory mustard plants (Brassicaceae, including Arabidopsis thaliana ) in fly genus Scaptomyza, nested within paraphyletic...
Abstract Herbivorous insects are exceptionally diverse, accounting for a quarter of all known eukaryotic species, but the genomic basis adaptations that enabled this dietary transition remains poorly understood. Many studies have suggested expansions and contractions chemosensory detoxification gene families—genes directly mediating interactions with plant chemical defenses—underlie successful colonization. However, hypothesis has been challenging to test because origins herbivory in many...
Herbivorous insects are exceptionally diverse, accounting for a quarter of all known eukaryotic species, but the genetic basis adaptations that enabled this dietary transition remains poorly understood. Many studies have suggested expansions and contractions chemosensory detoxification gene families - genes directly mediating interactions with plant chemical defenses underlie successful colonization. However, hypothesis has been challenging to test because origins herbivory in many lineages...
Abstract Circadian clocks orchestrate daily rhythms in organismal physiology and behavior to promote optimal performance fitness. In Drosophila , key pacemaker proteins PERIOD (PER) TIMELESS (TIM) are progressively phosphorylated perform phase-specific functions. Whereas PER phosphorylation has been extensively studied, systematic analysis of site-specific TIM is lacking. Here, we identified sites PER-bound by mass spectrometry, given the importance as a modulator function oscillator. Among...