A5100343147- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- ZnO doping and properties
- Gas Sensing Nanomaterials and Sensors
- Glycosylation and Glycoproteins Research
- Lipid metabolism and disorders
- Atherosclerosis and Cardiovascular Diseases
- Anodic Oxide Films and Nanostructures
- Studies on Chitinases and Chitosanases
- GaN-based semiconductor devices and materials
- Nitric Oxide and Endothelin Effects
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Liver physiology and pathology
- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Plant Virus Research Studies
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Protease and Inhibitor Mechanisms
- Immune Response and Inflammation
Yantai University
2019
Tianjin Medical University
2007-2018
Tianjin Infectious Diseases Hospital
2017
Recently, PIWIL4 has been identified as a functional protein involved in tumorigenesis. Cervical cancer is the second most prevalent form of worldwide. The relationship between and cervical still unknown. Here, we found that up‐regulated human tissues comparison to adjacent normal tissues, it promotes cell growth proliferation by inhibiting apoptosis through p14ARF/p53 pathway. can also promote invasion cells. These results suggest might play an oncogenic role be useful new therapeutic target future.
ABSTRACT MicroRNAs (miRNAs) are small, non‐coding RNAs that participate in the regulation of gene expression. Although many studies have demonstrated involvement miR‐17–5p different cancers, little is known to its function ovarian cancer. In this study, we overexpression was able enhance cell proliferation by promoting G1/S transition cycle and suppressing apoptosis ES‐2 OVCAR3 lines, whereas inhibition yielded reverse phenotype. YES1 identified as a novel target miR‐17–5p. Moreover, found...
// Qin-qin Li 1, * , Le Zhang Hai-ying Wan Min Liu 1 Xin Hua Tang Tianjin Life Science Research Center and School of Basic Medical Sciences, University, Tianjin, China These authors have contributed equally to this work Correspondence to: Tang, e-mail: htang2002@yahoo.com Keywords: CREB1, miR-320a, mitophagy, serum starvation, VDAC1 Received: April 26, 2015 Accepted: October 02, Published: 14, 2015 ABSTRACT The altered expression miRNAs in response stresses...
New evidence has shown that reduced β2-glycoprotein I (β2GPI) anti-oxidative stress and anti-inflammatory activity. However, the details are still poorly understood. This study aims to prepare stable β2GPI with its native bioactivity in vitro.Human was purified from plasma first perchloric acid precipitation then a series of chromatography methods including Sephadex G-25 desalting, SP HP, AF-heparin HC-650 M, Sephacryl S-200. The human thioredoxin-1 (TRX-1) activated by DL-dithiothreitol...
VEGF-NO axis uncoupling is an important pathogenesis for DN. Reduced β 2GPI could play a part in VEGF signaling pathway and has protective effect on diabetic vascular disease. This study investigates the of reduced glomerular mesangial cells induced by high glucose. Compared to control group, cell line HBZY-1 treated with glucose expressed higher levels mRNA protein produced more ROS but less NO. The related proteins were assayed. High significantly increase expression level VEGFR2 obviously...