A5064801815- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Cell death mechanisms and regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Iron Metabolism and Disorders
- Hemoglobin structure and function
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Nanoplatforms for cancer theranostics
- Erythrocyte Function and Pathophysiology
- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Tendon Structure and Treatment
- Plant Parasitism and Resistance
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Plant-Microbe Interactions and Immunity
Hangzhou Normal University
2015-2024
Shangqiu Normal University
2024
Jinan University
2024
First Affiliated Hospital of Jinan University
2024
Chongqing Medical University
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Abstract Disturbance of endoplasmic reticulum (ER) homoeostasis induces ER stress and leads to activation the unfolded protein response (UPR), which is an adaptive reaction that promotes cell survival or triggers apoptosis, when not restored. DDRGK1 membrane a critical component ubiquitin-fold modifier 1 (Ufm1) system. However, functions mechanisms in are largely unknown. Here, we show depletion enhances stress-induced apoptosis both cancer cells hematopoietic stem (HSCs). Depletion...
Wild-type p53-induced phosphatase 1 (Wip1) negatively regulates several tumour suppressor and DNA damage response pathways. However, the impact of Wip1 on haematopoietic stem cell (HSC) homeostasis aging remains unknown. Here we show that is highly expressed in HSCs but decreases with age. Wip1-deficient (Wip1−/−) mice exhibited multifaceted HSC phenotypes, including increased pool size impaired repopulating activity. Deletion p53 rescued multilineage repopulation defect Wip1−/− without...
Eosinophils (Eos) have been long considered as end-stage effector cells in the hierarchical hematopoietic system. Numerous lines of evidence suggested that Eos are multifunctional leukocytes with respect to initiation, propagation and regulation various inflammatory or immune reactions, especially allergic diseases. Recent studies shown also required for maintenance bone marrow plasma differentiation B cells. However, it remains unclear whether contributes stem cell (HSC) homeostasis. Here,...
Hematopoietic stem cells (HSCs) regenerate blood upon hematopoietic injuries. During homeostasis, HSCs are maintained in a low reactive oxygen species (ROS) state to prevent exhaustion. However, the role of nitric oxide (NO) controlling HSC regeneration is still unclear. Here, we find increased NO during with an accumulation protein aggregation. S-nitrosoglutathione reductase (GSNOR)-deleted exhibit reduced reconstitution capacity and loss self-renewal after chemotherapeutic injury, which...
Aging of hematopoietic stem cells (HSCs) has emerged as an important challenge to human health. Recent advances have raised the prospect rejuvenating aging HSCs via specific medical interventions, including pharmacological treatments. Nonetheless, efforts develop such drugs are still in infancy until now. We aimed screen prospective agents that can rejuvenate and explore potential mechanisms. screened a set natural anti-aging compounds through oral administration sub-lethally irradiated...
Abstract The expression of coinhibitory receptors, such as CTLA-4, on effector T cells is a key mechanism for the negative regulation T-cell activation. However, transcriptional CTLA-4 not well understood. Zfp281, C2H2 zinc finger protein, regulator pluripotency maintenance embryonic stem cells. Nevertheless, function Zfp281 in differentiated has been studied. We generated conditional knockout mice which gene was conditionally disrupted by Cd4 Cre transgene to study its impact cell function....
Small vessel vasculitis (SVV) is a group of systemic autoimmune diseases that are mediated by neutrophil extracellular traps (NETs) in response to cathelicidin LL37, an aging molecular marker, which could be induced telomere dysfunction. Therefore, this study, we evaluated the hypothesis dysfunction neutrophils may promote SVV via LL37-NETs-dependent mechanism.We contrasted release NETs from mice with dysfunction, DNA damage and wide-type mice. Neutrophil length, expression formation were...
Excessive protein synthesis upon enhanced cell proliferation frequently results in an increase of unfolded or misfolded proteins. During hematopoietic regeneration, to replenish the system, stem cells (HSCs) are activated and undergo a rapid proliferation. But how HSCs respond pressure is still ambiguous; The proper control functional reservoir remains poorly understood. Here, we show significant upregulation EVA1A associated with ER stress during regeneration. Deletion Eva1a significantly...