A5108039726- Color Science and Applications
- Color perception and design
- Visual perception and processing mechanisms
- Impact of Light on Environment and Health
- Renal and related cancers
- Image Enhancement Techniques
- Virtual Reality Applications and Impacts
- Advanced Optical Imaging Technologies
- Electronic Packaging and Soldering Technologies
- Consumer Perception and Purchasing Behavior
- Renal and Vascular Pathologies
- Olfactory and Sensory Function Studies
- Prostate Cancer Treatment and Research
- Osteoarthritis Treatment and Mechanisms
- Nanocluster Synthesis and Applications
- Heavy Metal Exposure and Toxicity
- Renal cell carcinoma treatment
- Graphene and Nanomaterials Applications
- Fibroblast Growth Factor Research
- Mesenchymal stem cell research
- Adhesion, Friction, and Surface Interactions
- Electrical Contact Performance and Analysis
- Human-Automation Interaction and Safety
- Dialysis and Renal Disease Management
- Ergonomics and Musculoskeletal Disorders
National Chung Hsing University
2024-2025
Pontificia Universidad Católica de Chile
2025
The University of Texas Southwestern Medical Center
2014-2024
Chang Gung University of Science and Technology
2021-2023
Texas Biomedical Research Institute
2023
Chihlee Institute of Technology
2021
Hong Kong Polytechnic University
2021
Research Center for Information Technology Innovation, Academia Sinica
2020
National Taiwan University of Science and Technology
2015-2016
International Center of Neurologic Restoration
2009-2011
Precise control of in vivo transport anticancer drugs normal and cancerous tissues with engineered nanoparticles is key to the future success cancer nanomedicines clinics. This requires a fundamental understanding how impact targeting-clearance permeation-retention paradoxes anticancer-drug delivery. Herein, we systematically investigated renal-clearable gold (AuNPs) affect permeation, distribution, retention drug doxorubicin both tissues. Renal-clearable AuNPs retain advantages free drug,...
With more and engineered nanoparticles (NPs) being designed renal clearable for clinical translation, fundamental understanding of their transport in the different compartments kidneys becomes increasingly important. Here, we report noninvasive X-ray imaging gold NPs (AuNPs) normal nephropathic kidneys. By quantifying kinetics AuNPs cortex, medulla pelvis injured kidneys, found that ureteral obstruction not just blocked NP elimination through ureter but also slowed down from to enhanced...
IFNγ, a potent cytokine known to modulate tumor immunity and tumoricidal effects, is highly elevated in patients with prostate cancer after radiation. In this study, we demonstrate that IFNγ can induce epithelial-to-mesenchymal transition (EMT) cells via the JAK-STAT signaling pathway, leading transcription of IFN-stimulated genes (ISG) such as IFN-induced tetratricopeptide repeat 5 (IFIT5). We unveil new function IFIT5 complex degrading precursor miRNAs (pre-miRNA) includes pre-miR-363 from...
Knee osteoarthritis (KOA) is a leading cause of disability, particularly affecting older adults due to the deterioration articular cartilage within knee joint. This condition characterized by pain, stiffness, and impaired movement, posing significant challenge in medical diagnostics treatment planning, especially current inability for early accurate detection or monitoring disease progression. research introduces multifaceted approach employing feature extraction machine learning (ML)...
Renal tubular secretion is an active efflux pathway for the kidneys to remove molecules but has yet be used enhance kidney cancer targeting. We report indocyanine green (ICG) conjugated with a 2100 Da PEG molecule (ICG-PEG45) as renal-tubule-secreted near-infrared-emitting fluorophore hyperfluorescence imaging of cancers, which cannot achieved hepatobiliary- and glomerular-clearable ICG. This pathway-dependent targeting arises from fact that enables ICG-PEG45 effectively effluxed out normal...
SPHK1 (sphingosine kinase type 1) is characterized as a rate-limiting enzyme in sphingolipid metabolism to phosphorylate sphingosine into sphingosine-1-phosphate (S1P) that can bind S1P receptors (S1PRs) initiate several signal transductions leading cell proliferation and survival of normal cell. Many studies have indicated involved types cancer development, however, little known bladder cancer. The TCGA database analysis was utilized for analyzing the clinical relevance Through CRISPR/Cas9...
Abstract Background Patients with inflammatory bowel diseases (IBD) may develop extraintestinal manifestations (EIM) that increase their morbidity. We investigated clinical and genetic factors associated EIM, analyzing an IBD cohort between 2019-2024. designed predictive models for EIM using machine learning techniques. Methods A total of 414 patients were recruited (314 UC 100 CD). The presence was assessed, differences the groups without analyzed Chi-square tests Mann-Whitney U tests. In a...
The appearance of white significantly impacts display image quality, requiring a neutral point for optimal performance. This study explores how perceived whiteness changes under ambient illumination levels (150, 300, 600, and 1200 lx) correlated color temperatures (3500 K 6500 K). As result, the adapted points light sources with different are similar at lower illuminance levels. In comparison, their adaptation trends exhibit significant differences higher At 150 lx, 3500 shift toward...
Abstract This research introduces a deep learning framework that combines convolutional neural networks with autoencoders to improve the diagnostic accuracy of knee osteoarthritis. The study utilized publicly available dataset from Mendeley Data repository, where joint images were preprocessed using Contrast Limited Adaptive Histogram Equalization enhance contrast and ensure consistent image sizing. Initially, an autoencoder was employed in unsupervised manner learn compressed...
Abstract Aberrant expression of transforming growth factor‐β1 (TGF‐β1) is associated with renal cell carcinoma (RCC) progression by inducing cancer metastasis. However, the downstream effector(s) in TGF‐β signaling pathway not fully characterized. In present study, elevation secreted protein acidic and rich cysteine (SPARC) as a regulated gene RCC was identified applying differentially expressed analysis microarray analysis, we further confirmed this result several lines. Clinically, these...
Tuberculosis (TB) accounts for 1.6 million deaths annually and over 25% of due to antimicrobial resistance. Mycobacterium tuberculosis (M.tb) drives MCL-1 expression (family member anti-apoptotic BCL-2 proteins) limit apoptosis grow intracellularly in human macrophages. The feasibility re-purposing specific inhibitors M.tb growth, using that are clinical trials FDA-approved cancer treatment has not be tested previously. We show specifically inhibiting induces M.tb-infected macrophages,...
Neuroendocrine prostate cancer (NEPC) is often diagnosed as a sub-type from the castration-resistant (CRPC) recurred second generation of anti-androgen treatment and rapidly progressive fatal disease. The molecular mechanisms underlying trans-differentiation CRPC to NEPC are not fully characterized, which hampers development effective targeted therapy.
Increased expression of PDGF-beta receptors is a landmark hepatic stellate cell activation and transdifferentiation into myofibroblasts. However, the molecular mechanisms that regulate fate receptor are lacking. Recent studies suggested N-acetylcysteine enhances extracellular degradation by cathepsin B, thus suggesting absence in quiescent cells due to an active process elimination not lack expression. In this communication we investigated further involved reappearance after incubation with...
Abstract Purpose: Renal cell carcinoma (RCC) is known to be highly radioresistant but the mechanisms associated with radioresistance have remained elusive. We found DOC-2/DAB2 interactive protein (DAB2IP) frequently downregulated in RCC, radioresistance. In this study, we investigated underlying mechanism regulating by DAB2IP and developed appropriate treatment. Experimental Design: Several RCC lines or without expression were irradiated ionizing radiation (IR) for determining their...
Abstract Precise control of in vivo transport anticancer drugs normal and cancerous tissues with engineered nanoparticles is key to the future success cancer nanomedicines clinics. This requires a fundamental understanding how impact targeting‐clearance permeation‐retention paradoxes anticancer‐drug delivery. Herein, we systematically investigated renal‐clearable gold (AuNPs) affect permeation, distribution, retention drug doxorubicin both tissues. Renal‐clearable AuNPs retain advantages...
Abstract With more and engineered nanoparticles (NPs) being designed renal clearable for clinical translation, fundamental understanding of their transport in the different compartments kidneys becomes increasingly important. Here, we report noninvasive X‐ray imaging gold NPs (AuNPs) normal nephropathic kidneys. By quantifying kinetics AuNPs cortex, medulla pelvis injured kidneys, found that ureteral obstruction not just blocked NP elimination through ureter but also slowed down from to...
In recent years, the general public and technology industry have favored stereoscopic vision, immersive experience, real-time visual information reception of virtual reality (VR) augmented (AR). The device carrier, Head-Mounted Display (HMD), is recognized as one next generation’s most promising computing communication platforms. HMD a image optical display that combines lens modules binocular displays. impact it brings much more complicated than traditional also influences performance...
Some emerging microelectromechanical systems (MEMS) devices such as high-performance inertial sensors and high-speed actuators must be operated in a high vacuum order to create this environment, specific packaging is required. To satisfy demand, paper presents novel method for hermetic near-vacuum of MEMS devices. We use wafer-level bonding technology combine with packaging, simultaneously. For solution, the wafers air-guided micro-through-holes were placed on custom-built design housed...
Abstract Two psychophysical experiments were conducted to investigate the color appearance under non‐uniform surround conditions with variation of stimulus luminance, background orientation, and size. The results show that size luminance influence intensively, but orientation pattern has little effect. A method determine optimal parameters for CIECAM02 model in lighting applications is proposed. An UGR‐based also optimized brightness estimation. adapting field can be estimated by...