A5008281708- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Tracheal and airway disorders
- Sarcoma Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Congenital Heart Disease Studies
- Intestinal Malrotation and Obstruction Disorders
- Appendicitis Diagnosis and Management
- Esophageal and GI Pathology
- Vascular Tumors and Angiosarcomas
- Dysphagia Assessment and Management
- Congenital gastrointestinal and neural anomalies
- Colorectal Cancer Surgical Treatments
- Global Health and Surgery
- Diversity and Career in Medicine
- Global Health Workforce Issues
- Cardiac, Anesthesia and Surgical Outcomes
- Body Contouring and Surgery
- Thyroid and Parathyroid Surgery
- Cardiac Fibrosis and Remodeling
- Head and Neck Anomalies
- Obstructive Sleep Apnea Research
- Ear and Head Tumors
- Foreign Body Medical Cases
- Educational Robotics and Engineering
Texas Children's Hospital
2022-2025
Baylor College of Medicine
2022-2025
Children's Cancer Center
2025
Nationwide Children's Hospital
2015-2020
The Ohio State University
2015-2020
The Ohio State University Wexner Medical Center
2015-2020
Howard University
2011
We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of U.S. Food Drug Administration (FDA)-approved clinical trial evaluating this patients with single-ventricle cardiac anomalies. The TEVG was used as Fontan conduit to connect the inferior vena cava pulmonary artery, but high incidence narrowing manifested within first 6 months, which treated successfully angioplasty. To elucidate mechanisms underlying early stenosis, we data-informed,...
ABSTRACT Background Wilms tumor (WT) is the most common pediatric malignancy of kidney. Past studies describing WT incidence and survival used surveillance data with < 30% US population. We evaluated differences in comparing demographic groups characteristics. Methods analyzed new cases among patients aged 20 years at diagnosis by using from Cancer Statistics (USCS) for 2003–2020 5‐year relative (RS) National Program Registries (NPCR) 2001–2019. To assess trends, average annual percent...
Humans receiving tissue-engineered tracheal grafts have experienced poor outcomes ultimately resulting in death or the need for graft explantation. We assessed performance of synthetic scaffolds used humans with an ovine model orthotopic replacement, applying standard postsurgical surveillance and interventions to define factors that contributed complications seen at bedside.Large animal model.Pediatric academic research institute.Human were manufactured electrospun blend polyethylene...
There appears to be an increasing acceptance of cosmetic surgery procedures among minority populations in America. Our objective was determine trends elective procedure utilization as they apply racial/ethnic differences. A retrospective analysis performed using the Nationwide Inpatient Sample. Adult patients undergoing defined by appropriate International Classification Disease 9 Clinical Modification codes were included. Demographic characteristics and hospital course particulars...
Aim: This study evaluates scaffold degradation and neotissue formation as a function of sealant polymer composition in tissue-engineered vascular grafts (TEVGs). Materials & methods: Scaffolds fabricated from polyglycolic acid core composed polycaprolactone (PCL), poly-L-lactic-acid (PLLA) or 50:50 copolymer poly(ε-caprolactone-co-L-lactide) (PCLA) were analyzed vitro using accelerated scanning electron microscopy, vivo following implantation murine inferior vena cava interposition model....
Aim: Inflammatory myeloid lineage cells mediate neotissue formation in tissue-engineered vascular grafts, but the molecular mechanism is not completely understood. We examined role of vasculogenic PDGF-B graft development. Materials & methods: Myeloid cell-specific knockout mice (PDGF-KO) were generated using bone marrow transplantation, and scaffolds implanted as inferior vena cava interposition grafts either PDGF-KO or wild-type mice. Results: After 2 weeks, from had more remaining...
Objective To evaluate the safety and efficacy of bronchoscopic interventions in management tissue‐engineered tracheal graft (TETG) stenosis. Study Design Animal research study. Methods TETGs were constructed with seeded autologous bone marrow‐derived mononuclear cells on a bioartificial graft. Eight sheep underwent resection orthotopic implantation this construct. Animals monitored by bronchoscopy fluoroscopy at 3 weeks, 6 months, 4 months. Bronchoscopic interventions, including dilation...
Current techniques for airway characterization include endoscopic or radiographic measurements that produce static, two-dimensional descriptions. As pathology can be multilevel, irregularly shaped, and dynamic, minimal luminal area (MLA) may not provide the most comprehensive description diagnostic metric. Our aim was to examine utilization of computational fluid dynamics (CFD) purpose defining stenosis using an ovine model tissue-engineered tracheal graft (TETG) implantation.Animal research...