A5004443940- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Vascular anomalies and interventions
- Cardiovascular Issues in Pregnancy
- Cardiac tumors and thrombi
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Congenital heart defects research
- Ultrasound in Clinical Applications
- Cardiovascular and Diving-Related Complications
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Atomic and Subatomic Physics Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and Vascular Pathologies
- Infective Endocarditis Diagnosis and Management
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
Boston Children's Museum
2012-2024
Université Paris Cité
2021
Harvard University Press
2005-2020
Hospital de Santa Marta
2018
Centro Hospitalar de Lisboa Central
2018
Brigham and Women's Hospital
1998-2017
GTx (United States)
2017
Boston University
1990-2016
Factors associated with impaired clinical status in a cross-sectional study of patients repaired tetralogy Fallot (TOF) have been reported previously.To determine independent predictors major adverse outcomes late after TOF repair the same cohort during follow-up evaluated by cardiac magnetic resonance (CMR).Clinical at latest was ascertained 88 (median time from to baseline evaluation 20.7 years; median most recent 4.2 years). Major included (a) death; (b) sustained ventricular tachycardia;...
<h3>Objective</h3> Patients with repaired tetralogy of Fallot (TOF) experience increased rates mortality and morbidity in adulthood. This study was designed to identify risk factors for death ventricular tachycardia (VT) a large contemporary cohort patients TOF. <h3>Methods</h3> Subjects TOF from four congenital heart centres the USA, Canada Europe were enrolled. Clinical, ECG, exercise, cardiac magnetic resonance (CMR) outcome data analysed. <h3>Results</h3> Of 873 (median age 24.4 years),...
This paper aims to provide information and explanations regarding the clinically relevant options, strengths, limitations of cardiovascular magnetic resonance (CMR) in relation adults with congenital heart disease (CHD). Cardiovascular can assessments anatomical connections, biventricular function, myocardial viability, measurements flow, angiography, more, without ionizing radiation. It should be regarded as a necessary facility centre specializing care CHD. Also, those using CMR...
Background— Pulmonary valve replacement (PVR) in repaired tetralogy of Fallot (TOF) reduces pulmonary regurgitation and decreases right ventricular (RV) dilation, but its long-term impact on tachycardia (VT) mortality is unknown. This study aimed to determine the incidence death VT TOF after PVR test hypothesis that leads improvement these outcomes. Methods Results— A total 98 patients with late for RV dilation were identified. Matched control subjects identified 77 patients; had no PVR....
Abstract Purpose To determine the inter‐ and intraobserver reproducibility of cardiac magnetic resonance (CMR)‐derived measurements right ventricular (RV) mass, volume, function in patients with normal dilated ventricles. Materials Methods CMR studies 60 three groups were studied: a RV group ( N = 20) two dilation—atrial septal defect (ASD) repaired tetralogy Fallot (TOF) 20). Two independent observers analyzed each study on separate occasions. Inter‐ biventricular ejection fraction (EF),...
Arterial tortuosity is described as a common and distinctive feature of Loeys-Dietz syndrome (LDS), yet reports on arterial are based qualitative observations none have investigated an association between cardiovascular outcomes in LDS or other connective tissue disorders.We performed retrospective analysis 90 patients ≤50 years age with Marfan syndrome, LDS, Ehlers-Danlos nonspecific disorder who underwent thoracic contrast-enhanced magnetic resonance angiography. Controls (n=30) imaging to...
Risk factors for adverse clinical outcomes have been identified in patients with repaired tetralogy of Fallot before pulmonary valve replacement (PVR). However, pre-PVR predictors post-PVR sustained ventricular tachycardia and death not identified.Patients enrolled the INDICATOR cohort (International Multicenter TOF Registry), a 4-center international study, who had comprehensive preoperative evaluation subsequently underwent PVR were included. Preprocedural clinical, ECG, cardiovascular...
The impact of pulmonary valve replacement (PVR) on major adverse clinical outcomes in patients with repaired tetralogy Fallot (rTOF) is unknown. purpose this study was to determine whether PVR associated improved survival and freedom from sustained ventricular tachycardia (VT) rTOF. A propensity score created adjust for baseline differences between non-PVR enrolled INDICATOR (International Multicenter TOF Registry). primary outcome time the earliest occurrence death or VT. were matched 1:1...
Artificial intelligence-enhanced ECG analysis shows promise to detect ventricular dysfunction and remodeling in adult populations. However, its application pediatric populations remains underexplored.
BACKGROUND In adults, acquired pressure-overload left ventricular hypertrophy can result in myocardial ischemia, which may be due part to insufficient capillary growth during development of hypertrophy. The coronary microvascular response congenital children has not been previously characterized. METHODS AND RESULTS Average density and heterogeneity spacing were measured 63 postmortem human hearts with control without heart disease. Pathology specimens chosen that had caused by 1) isolated...
The underlying mechanisms that contribute to global right ventricular (RV) dysfunction in patients with repaired tetralogy of Fallot are incompletely understood. We therefore sought quantify regional RV abnormalities and determine the relationship these function exercise capacity.Clinical cardiac magnetic resonance data from 62 consecutive were analyzed (median age at follow-up 23 years [limits 9 67 years]). Using data, 3D endocardial surface models reconstructed segmented contours, a...
Background — In patients with complex pulmonary stenosis or atresia, a detailed delineation of all sources blood supply is necessary for planning surgical and transcatheter procedures usually requires diagnostic cardiac catheterization. The goals this study were to determine whether gadolinium-enhanced 3D magnetic resonance angiography (MRA) can provide noninvasive alternative catheterization compare MRA x-ray measurements arteries aortopulmonary collaterals (APCs). Methods Results...
Accurate quantitative evaluation of right ventricular (RV) function has been limited by its complex structural geometry. Although embryological and anatomic observations suggest that the RV is composed 2 distinct components, sinus infundibulum, most studies on dimensions viewed it as a single chamber. This study was designed to determine volumes, relative contribution global systolic function, temporal course contraction relaxation infundibulum.Thirty-one individuals without heart disease...