A5008492692- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Central Venous Catheters and Hemodialysis
- Cardiovascular Issues in Pregnancy
- Vascular anomalies and interventions
- Coronary Artery Anomalies
- Cardiovascular Conditions and Treatments
- Renal and Vascular Pathologies
- Infective Endocarditis Diagnosis and Management
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular Anomalies and Treatments
- Hemodynamic Monitoring and Therapy
- Coronary Interventions and Diagnostics
- Cardiovascular and Diving-Related Complications
- Ultrasound in Clinical Applications
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Aortic aneurysm repair treatments
- Cardiac pacing and defibrillation studies
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
Children's Hospital of Philadelphia
2014-2024
Boston Children's Museum
2013-2023
Brigham and Women's Hospital
2022
University of San Carlos of Guatemala
2021
Boston University
2021
Yale New Haven Hospital
2018
Rockefeller University
2018
Sheba Medical Center
2018
Melody Transcatheter Pulmonary Valve (TPV) replacement therapy represents an important advance in congenital cardiovascular interventions. The off-label extension of the TPV to patients with nonconduit outflow tracts (right ventricular tract [RVOT]) has potential vastly expand population eligible benefit from nonsurgical restoration RVOT function. However, knowledge on performance this setting is limited.This a multicenter, retrospective review when placed RVOTs, which at least portion...
The technique and safety of transcatheter patent ductus arteriosus (PDA) closure have evolved during the past 20 years. We sought to report a multicenter experience PDA with focus on rate adverse events (AE) review institutional practice differences.Outcome data were collected at 8 centers prospectively using registry (Congenital Cardiac Catheterization Project Outcome Registry). Between February 2007 June 2010, 496 closures recorded device in 338 (68%) or coils 158 (32%). Most patients had...
Objective To describe contemporary outcomes of balloon aortic valvuloplasty (BAVP) performed in 22 US centers. Background : BAVP constitutes first‐line therapy for congenital stenosis (cAS) many Methods We used prospectively‐collected data from two active, multi‐institutional, pediatric cardiac catheterization registries. Acute procedural success was defined, purposes this review, as a residual peak systolic gradient ≤ 35 mm Hg and no more than mild regurgitation (AR) patients with isolated...
Background: Secundum atrial septal defect (ASD) closure devices were granted approval based on industry‐sponsored, prospective, nonrandomized, single device studies, demonstrating acceptable efficacy and safety in selected patients. We sought to report community practice outcomes. Methods Results: Procedure specific data was collected cases considered for ASD the congenital cardiac catheterization project outcomes (C3PO) between February 1, 2007 June 31, 2010. Eight centers contributed...
Background: Fetal aortic valvuloplasty (FAV) may prevent progression of midgestation stenosis to hypoplastic left heart syndrome. However, FAV has well-established risks, and its survival benefit remains unknown. Our primary aim was determine whether for increases from fetal diagnosis age 6 years. Methods Results: We performed a retrospective analysis 143 fetuses who underwent 2000 2017 secondary the Pediatric Heart Network Single Ventricle Reconstruction trial. Using these results, we...
Background/Objectives: Premature infants are often referred for the definitive procedural closure of patent ductus arteriosus (PDA) with failure of, or contraindication to, pharmacotherapy and inability to wean respiratory support. However, once this need is identified, importance expedited unclear. The objective study was compare effect timing (i.e., surgical ligation device occlusion) on early outcomes in premature infants. Method: We first specify a hypothetical randomized trial (the...
Continued advancements in congenital cardiac catheterization and interventions have resulted increased patient procedural complexity. Anticipation of life-threatening events required rescue measures is a critical component to preprocedural preparation. We sought determine the incidence nature adverse pediatric catheterization, risk factors, resources necessary anticipate manage events. Data from 8905 cases performed at 8 participating institutions Congenital Cardiac Catheterization Project...
Introduction Standardization of care can reduce practice variation, optimize resource utilization, and improve clinical outcomes. We have created a standardized assessment management plan (SCAMP) for patients having balloon aortic valvuloplasty (BAV) congenital stenosis (AS). This study compares acute outcomes BAV at our institution before after introduction this SCAMP. Methods In retrospective matched cohort study, each SCAMP patient was to four historical controls. Outcomes were...
Neural crest cells are thought to play a critical role in human conotruncal morphogenesis and dysmorphogenesis. Much of our understanding the contribution neural cardiovascular patterning comes from ablation transplantation experiments avian species. Although fate mapping mice suggests conservation function, functional requirement for development mammals has not been formally tested. We used novel two component genetic system temporal-spatial mouse. Affected embryos displayed spectrum...
Treatment with endovascular stents has become increasingly common for the management of vascular stenosis in congenital heart disease. The use smaller patients been tempered by concerns about potential stent expansion to accommodate somatic growth. One solution limited diameter is intentional fracture maximally dilated stents, which can be accomplished using ultra-high-pressure (UHP) balloons.This retrospective cohort study compared procedural characteristics and adverse events between a...
To assess the variation in timing of left atrial decompression and its association with clinical outcomes pediatric patients supported venoarterial extracorporeal membrane oxygenation across a multicenter cohort.Multicenter retrospective study.Eleven hospitals within United States.Patients less than 18 years on who underwent from 2004 to 2016.None.A total 137 (median age, 4.7 yr) were included. Cardiomyopathy was most common diagnosis (47%). Cardiac arrest (39%) low cardiac output (50%)...
Midaortic syndrome (MAS) is a rare cause of severe childhood hypertension characterized by narrowing the abdominal aorta in children and associated with extensive vascular disease. It may occur as part genetic syndrome, such neurofibromatosis, or consequence pathological inflammatory However, most cases are considered idiopathic. We hypothesized that high percentage these patients, monogenic disease be detected evaluating whole exome sequencing data for mutations 1 38 candidate genes...
Objective The objective of this study was to investigate variation in practice surrounding elective cardiac catheterization patients with single-ventricle (SV) congenital heart disease. Design Patient and procedural characteristics outcomes during SV were collected prospectively from eight centers using a web-based registry (Congenital Cardiac Catheterization Project on Outcomes). We attempted identify population procedures by limiting the cohort case type timing. Cases then stratified stage...