A5066462549- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Evolutionary Psychology and Human Behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Neural and Behavioral Psychology Studies
- Action Observation and Synchronization
- Mental Health Research Topics
- Personality Disorders and Psychopathology
- Psychology of Moral and Emotional Judgment
- Neural dynamics and brain function
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Face Recognition and Perception
- Language, Metaphor, and Cognition
- Deception detection and forensic psychology
- Attention Deficit Hyperactivity Disorder
- Hormonal and reproductive studies
- Child and Animal Learning Development
- Obsessive-Compulsive Spectrum Disorders
- Hypothalamic control of reproductive hormones
- Child Abuse and Trauma
- Behavioral Health and Interventions
- Neuroscience, Education and Cognitive Function
- Migraine and Headache Studies
Wellcome Centre for Integrative Neuroimaging
2018-2023
University of Oxford
2018-2023
John Radcliffe Hospital
2020-2023
Oxford Health NHS Foundation Trust
2020
Warneford Hospital
2020
Radboud University Nijmegen
2009-2019
University College London
2015-2018
University Hospital Heidelberg
2018
Heidelberg University
2018
National Hospital for Neurology and Neurosurgery
2017-2018
It is clear that the steroid hormone testosterone plays an important role in regulation of social emotional behavior, but it remains unknown which neural circuits mediate these hormonal influences humans. We investigated modulatory effects endogenous on control behavior by applying functional magnetic resonance imaging while healthy male participants performed a approach-avoidance task. This task operationalized having approach and avoid faces pulling pushing joystick, respectively....
Psychopathy (PP) is associated with marked abnormalities in social emotional behaviour, such as high instrumental aggression (IA). A crucial but largely ignored question whether automatic approach-avoidance tendencies may underlie this condition. We tested offenders PP show lack of avoidance tendencies, usually activated when (healthy) individuals are confronted threat stimuli (angry faces). applied a computerized task (AAT), where participants pushed or pulled pictures faces using joystick,...
How can we understand each other during communicative interactions? An influential suggestion holds that communicators are primed by other's behaviors, with associative mechanisms automatically coordinating the production of signals and comprehension their meanings. alternative posits mutual understanding requires shared conceptualizations a signal's use, i.e., "conceptual pacts" abstracted away from specific experiences. Both accounts predict coherent neural dynamics across communicators,...
Abstract Animal and human studies have shown that both early-life traumatic events ongoing stress episodes affect neurodevelopment, however, it remains unclear whether how they modulate normative adolescent neuro-maturational trajectories. We characterized effects of (age 0–5) stressors 14–17) on longitudinal changes 14 to17) in grey matter volume (GMV) healthy adolescents (n = 37). Timing stressor type were related to differential GMV changes. More personal stressful associated with larger...
Testosterone administration in human participants increased amygdala responses during threat approach and decreased it avoidance.
<h3>Abstract</h3> Psychopathic individuals are notorious for their controlled goal-directed aggressive behavior. Yet, during social challenges, they often show uncontrolled emotional Healthy can control behavior through anterior prefrontal cortex (aPFC) downregulation of neural activity in the amygdala, with testosterone modulating aPFC–amygdala coupling. This study tests whether individual differences this neuroendocrine system relate to paradoxical lack observed human psychopathic...
Increased limbic and striatal activation in adolescence has been attributed to a relative delay the maturation of prefrontal areas, resulting increase impulsive reward-seeking behaviors that are often observed during puberty. However, it remains unclear whether how this general developmental pattern applies control social emotional actions, fundamental adult skill refined adolescence. This domain pertains decisions involving responses. When faced with challenge (e.g., an angry face), we can...
After a threatening event, the risk of developing social psychopathologies is increased in short-allele (s) carriers serotonin transporter gene. The amygdala becomes overresponsive to emotional stimuli, an effect that could be driven by local hypersensitivity or reduced prefrontal regulation. This study distinguishes between these two hypotheses using dynamic causal modeling fMRI data acquired preselected cohort human s-carriers and homozygous long-allele carriers. Increased activity...
Difficulty in controlling emotional impulses is a crucial component of borderline personality disorder (BPD) that often leads to destructive, impulsive behaviours against others. In line with recent findings aggressive individuals, deficits prefrontal amygdala coupling during action control may account for these symptoms.To study the neurobiological correlates altered individuals BPD, we asked medication-free, anger-prone, female patients BPD and age- intelligence-matched healthy women take...
Criminal behaviour poses a big challenge for society. A thorough understanding of the neurobiological mechanisms underlying criminality could optimize its prevention and management. Specifically,elucidating neural underpinning reward expectation might be pivotal to criminal behaviour. So far no study has assessed in sample. To fill this gap, we incarcerated, psychopathic criminals. We compared group two groups non-criminal individuals: one with high levels another low impulsive/antisocial...
Background: Interpersonal deficits are a core symptom of borderline personality disorder (BPD), which could be related to increased social threat sensitivity and tendency approach rather than avoid interpersonal threats. The neuropeptide oxytocin has been shown reduce in patients with BPD modify approach-avoidance behavior healthy volunteers. Methods: In randomized, double-blind placebo-controlled between-subject design, 53 unmedicated women 61 participated an task 75 min after intranasal...
Social anxiety and psychopathy have conceptually been linked to nearly opposite emotional, behavioral endocrinological endophenotypes, representing social fearfulness fearlessness, respectively. Although such a dimensional view has theoretical practical implications, no study directly compared in terms of emotional experiences, relevant hormones (i.e. cortisol, testosterone) tendencies approach-avoidance). Therefore, the present examined 1) whether self-reported psychopathic traits are...
ORIGINAL RESEARCH article Front. Hum. Neurosci., 22 November 2012Sec. Cognitive Neuroscience Volume 6 - 2012 | https://doi.org/10.3389/fnhum.2012.00310
BackgroundInstrumental action is well known to be vulnerable affective value. Excessive transfer of value instrumental thought contribute psychiatric disorders. The brain region most commonly implicated in overriding such biasing the prefrontal cortex.ObjectiveThe aim present study was reduce using transcranial direct current stimulation (tDCS) young healthy human volunteers.MethodsIn a double-blind, randomized between-group design, 120 participants received anodal, cathodal and sham tDCS...
Abstract Social–emotional cues, such as affective vocalizations and emotional faces, automatically elicit action tendencies. Adaptive social–emotional behavior depends on the ability to control these automatic It remains unknown whether neural over tendencies is supramodal or relies parallel modality-specific circuits. Here, we address this largely unexplored issue in humans. We consider circuits supporting response vocalizations, using an approach–avoidance task known reliably index...