A5065615661- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Muscle activation and electromyography studies
- Functional Brain Connectivity Studies
- Motor Control and Adaptation
- Vestibular and auditory disorders
- Neurological disorders and treatments
- Traumatic Brain Injury Research
- EEG and Brain-Computer Interfaces
- Amyotrophic Lateral Sclerosis Research
- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Pain Management and Treatment
- Alzheimer's disease research and treatments
- Obsessive-Compulsive Spectrum Disorders
- Parkinson's Disease Mechanisms and Treatments
- Spatial Neglect and Hemispheric Dysfunction
- Advanced Neuroimaging Techniques and Applications
- Hemispheric Asymmetry in Neuroscience
- Neural dynamics and brain function
- Attention Deficit Hyperactivity Disorder
- Migraine and Headache Studies
- Advanced MRI Techniques and Applications
- Action Observation and Synchronization
- Optical Imaging and Spectroscopy Techniques
National Institute of Neurological Disorders and Stroke
2015-2025
National Institutes of Health
2014-2025
National Institute of Mental Health
1998-2021
Government of the United States of America
2021
Naval Medical Research Command
2021
National Institutes of Health Clinical Center
2021
University of Florida Health
2021
Pennsylvania State University
2021
Walter Reed Army Institute of Research
2021
University of Virginia
2021
We studied the effects of low-frequency transcranial magnetic stimulation (TMS) on motor cortex excitability in humans. TMS at 0.1 Hz for 1 hour did not change cortical excitability. Stimulation 0.9 15 minutes (810 pulses), similar to parameters used induce long-term depression (LTD) slice preparations and vivo animal studies, led a mean decrease evoked potential (MEP) amplitude 19.5%. The lasted least after end stimulation. mechanism underlying this may be LTD. TMS-induced reduction has...
We applied trains of focal, rapid-rate transcranial magnetic stimulation (rTMS) to the motor cortex 14 healthy volunteers with recording EMG from contralateral abductor pollicis brevis, extensor carpi radialis, biceps brachii and deltoid muscles. Modulation amplitude evoked potentials (MEPs) produced in target muscle during rTMS showed a pattern inhibitory excitatory effects which depended on frequency intensity. With coil situated over optimal scalp position for activating led spread...
Converging evidence points to hypofunction of the left prefrontal cortex in depression. Repetitive transcranial magnetic stimulation (rTMS) activates neurons near surface brain. We questioned whether daily rTMS might improve mood depressed subjects and report a pilot study such treatment six highly medication-resistant inpatients. Depression scores significantly improved for group as whole (Hamilton Scores decreased from 23.8 ± 4.2 (s.d.) at baseline 17.5 8.4 after treatment; t = 3.03, 5DF,...
<b>Background:</b> Data from the human motor cortex suggest that, depending on polarity, direct current (DC) brain polarization can depress or activate cortical neurons. Activating effects frontal lobe might be beneficial for patients with disorders. This phase 1 study tested safety of DC, including its and other functions. <b>Methods:</b> The authors applied 20 minutes anodal, cathodal, sham DC to left prefrontal in three groups right-handed subjects looked global measures processing...
Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design.Twelve depressed adults received in random order 2 weeks of active treatment (repetitive stimulation, 20 Hz at 80% motor threshold) and sham treatment.Changes from the relevant phase baseline scores on 21-item Hamilton depression scale showed significantly improved mood...
Clinical recovery after stroke can be significant and has been attributed to plastic reorganization recruitment of novel areas previously not engaged in a given task. As equivocal results have reported studies using single imaging or electrophysiological methods, here we applied an integrative multimodal approach group well-recovered chronic patients (n = 11; aged 50–81 years) with left capsular lesions. Focal activation during recovered hand movements was assessed EEG spectral analysis...
Transcranial magnetic stimulation (TMS) of the human motor cortex results in multiple discharges (D and I waves) corticospinal tract. We tested whether these volleys can be explored non‐invasively with paired TMS. The intensity first stimulus (S1) was set to produce a motor‐evoked potential (MEP) 1 mV resting contralateral abductor digiti minimi (ADM) muscle; second (S2) 90 % threshold. At interstimulus intervals 1·1‐1·5, 2·3‐2·9 4·1‐4·4 ms MEP elicited by S1 plus S2 larger than that...
<h3>Background</h3> Progression of Parkinson9s disease (PD) is characterised by motor deficits which eventually respond less to dopaminergic therapy and thus pose a therapeutic challenge. Deep brain stimulation has proven efficacy but carries risks not possible in all patients. Non-invasive shown promising results may provide alternative. <h3>Objective</h3> To investigate the transcranial direct current (tDCS) treatment PD. <h3>Design</h3> Randomised, double blind, sham controlled study....