A5026237408- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Biomedical and Chemical Research
- Cerebral Palsy and Movement Disorders
- Vestibular and auditory disorders
- Acute Ischemic Stroke Management
- Genetic Neurodegenerative Diseases
- Balance, Gait, and Falls Prevention
- Neuroscience and Neural Engineering
- Motor Control and Adaptation
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Peripheral Neuropathies and Disorders
- Pain Management and Treatment
- Restless Legs Syndrome Research
- Cancer Treatment and Pharmacology
- Myasthenia Gravis and Thymoma
- Neurological Disorders and Treatments
- Spinal Fractures and Fixation Techniques
University Hospital of Lausanne
2014-2024
University of Lausanne
2017-2024
Reha Rheinfelden
2024
Hôpital Orthopédique de la Suisse Romande
2012-2018
Royal Cornwall Hospital
2017
National Institutes of Health
2008-2015
National Institute of Neurological Disorders and Stroke
2008-2015
Laboratoire de Neurobiologie Cellulaire et Moléculaire
2012
University Hospital of Basel
2011
National Institute of Mental Health
2011
Background and Purpose— Few data exist about clinical, radiologic findings, clinical outcome, its predictors in patients with spontaneous vertebral artery dissection (sVAD). Methods— Clinical characteristics, imaging 3-month outcomes, were investigated consecutive sVAD. Results— One hundred sixty-nine 195 sVAD identified. Brain ischemia occurred 131 (77%; ischemic stroke, n=114, 67%; transient attack, n=17, 10%). Three stroke showed also signs of subarachnoid hemorrhage (SAH); 3 (2%) had SAH...
<h3>Background</h3> Progression of Parkinson9s disease (PD) is characterised by motor deficits which eventually respond less to dopaminergic therapy and thus pose a therapeutic challenge. Deep brain stimulation has proven efficacy but carries risks not possible in all patients. Non-invasive shown promising results may provide alternative. <h3>Objective</h3> To investigate the transcranial direct current (tDCS) treatment PD. <h3>Design</h3> Randomised, double blind, sham controlled study....
Background and Purpose— It is unclear whether intraarterial (IAT) or intravenous (IVT) thrombolysis more effective for ischemic stroke with hyperdense middle cerebral artery sign (HMCAS) on computed tomography (CT). The aim of this study was to compare IAT IVT in patients HMCAS. Methods— Comparison data from 2 units similar management associated HMCAS, except that 1 unit performed urokinase the other plasminogen activator. Time treatment up 6 hours 3 IVT. Outcome measured by mortality...
It is unclear whether stroke in patients with spontaneous dissection of the cervical internal carotid artery (ICAD) due to thromboembolism or impaired hemodynamics. This study investigated mechanism ICAD by examining brain imaging and cerebrovascular findings such patients.We retrospectively evaluated prospectively collected CT, MR, ultrasound 141 consecutive 143 ICADs causing ischemic stroke. Eleven were not included because they had an inappropriate temporal bone window (n=6) treated...
<h3>Objective:</h3> To investigate the safety and efficacy of intermittent theta-burst stimulation (iTBS) in treatment motor symptoms Parkinson disease (PD). <h3>Background:</h3> Progression PD is characterized by emergence deficits, which eventually respond less to dopaminergic therapy pose a therapeutic challenge. Repetitive transcranial magnetic (rTMS) has shown promising results improving gait, major cause disability, may provide alternative. iTBS novel type rTMS that be more efficacious...
<h3>Objective:</h3> To determine the clinical phenotype and outcome in hepatitis E virus–associated neuralgic amyotrophy (HEV-NA). <h3>Methods:</h3> Cases of NA were identified 11 centers from 7 European countries, with retrospective analysis demographics, clinical/laboratory findings, treatment outcome. HEV-NA compared cases without evidence HEV infection. <h3>Results:</h3> Fifty-seven 61 studied. Fifty-six 57 anti-HEV IgM positive; 53/57 IgG positive. In 38 cases, RNA was recovered serum 1...
<b><i>Objective:</i></b> To compare the rate of ischemic events and intracranial hemorrhage in long-term follow-up patients with persistent transient severe stenosis or occlusion internal carotid artery (ICA) due to spontaneous dissection (ICAD). <b><i>Methods:</i></b> One hundred sixty-one consecutive unilateral ICAD causing were examined clinically by ultrasound 1 year after symptom onset. Forty-six cases 46 age- latency-matched (recanalization complete less than 50% stenosis) ICA...
<i>Background/Aims:</i> Excessive daytime sleepiness (EDS) is frequent in patients with Parkinson’s disease (PD). Occasionally, EDS PD exhibits narcolepsy-like features. We aimed to assess characteristics and determinants of consecutive PD. <i>Methods:</i> Thirty underwent a detailed clinical examination. was assessed using the Epworth Sleepiness Scale (ESS) Multiple Sleep Latency Test (MSLT). video-polysomnography. Cerebrospinal fluid (CSF) hypocretin-1 levels were...
Objective. To investigate the safety and efficacy of 50-Hz repetitive transcranial magnetic stimulation (rTMS) in treatment motor symptoms Parkinson disease (PD). Background. Progression PD is characterized by emergence deficits that gradually respond less to dopaminergic therapy. rTMS has shown promising results improving gait, a major cause disability, may provide therapeutic alternative. Prior controlled studies suggest an increase frequency might enhance efficacy. Methods. In this...
Spontaneous dissection of the cervical internal carotid artery (sICAD) is mainly assessed with MRI and magnetic resonance angiography (MRA), which are not always at hand. In contrast, color duplex sonography (CDS) readily available. We undertook this prospective study to examine accuracy CDS diagnose sICAD in patients first territory ischemia.Consecutive stroke or transient ischemic attack retinal ischemia underwent clinical laboratory examinations, ECG, cerebral arteries, cranial computed...
The treatment of writer's cramp, a task-specific focal hand dystonia, needs new approaches. A deficiency inhibition in the motor cortex might cause cramp. Transcranial direct current stimulation modulates cortical excitability and may provide therapeutic alternative. In this randomized, double-blind, sham-controlled study, we investigated efficacy cathodal contralateral 3 sessions 1 week. Assessment over 2-week period included clinical scales, subjective ratings, kinematic handwriting...
Isolated Horner syndrome without associated cranial nerve palsies or ischemic symptoms is an important presentation of spontaneous internal carotid artery dissection (sICAD). Ultrasound often used as a screening method in these patients because cervical MRI not always available on emergency basis. Current knowledge ultrasound findings with sICAD presenting isolated limited.Patients were recruited from prospective databases 3 tertiary care centers. Diagnosis was confirmed by and MR...
Few data exist on long-term outcome of patients with cervical aneurysm due to spontaneous dissection the internal carotid artery (sICAD).1,2 In this prospective observational study, we assessed risk stroke, rupture, and development local symptoms or signs side (headache, neck pain, Horner syndrome, cranial nerve palsy) in aneurysms caused by sICAD. We included 279 consecutive sICAD (diagnosed as previously reported)3 who underwent cerebral MR angiography (MRA; n = 195), digital subtraction...
Excessive beta oscillatory activity in the subthalamic nucleus (STN) is linked to Parkinson's Disease (PD) motor symptoms. However, previous works have been inconsistent regarding functional role of untreated Parkinsonian states, questioning such role. We hypothesized that this inconsistency due influence electrophysiological broadband -a neurophysiological indicator synaptic excitation/inhibition ratio- could confound measurements STN recordings. Here we propose a data-driven, automatic and...