A5002122520- Folate and B Vitamins Research
- Esophageal and GI Pathology
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Social and Educational Sciences
- Estrogen and related hormone effects
- Child Nutrition and Feeding Issues
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Dysphagia Assessment and Management
- Infrared Thermography in Medicine
- Gastroesophageal reflux and treatments
- Metabolism and Genetic Disorders
- GDF15 and Related Biomarkers
- Alkaline Phosphatase Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Alcoholism and Thiamine Deficiency
- Thermal Regulation in Medicine
- Neurological diseases and metabolism
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
University of Gothenburg
2013-2025
Chalmers University of Technology
2022
Lund University
2007-2020
Skåne University Hospital
2014-2020
University of California, San Francisco
2018
Unité de Nutrition Humaine
2018
Karolinska University Hospital
2000
Background: Inherited mutations in the CDKN2A tumor suppressor gene, which encodes p16INK4a protein, and cyclin-dependent kinase 4 (CDK4) gene confer susceptibility to cutaneous malignant melanoma. We analyzed families with two or more cases of melanoma for germline CDK4 elucidate contribution these defects familial occurrence other cancer types. Methods: The entire coding region exon 2 an affected member each 52 from southern Sweden at least first- second-degree relatives were screened by...
Abstract. Plasma homocysteine concentration is a sensitive marker for cobalamin and folate deficiency. The previously reported high incidence of increased plasma in psychogeriatric patients the association between reduced concentrations cobalamin, neuropsychiatric symptoms led to present study on 741 consecutive patients. correlated significantly with blood folate, serum creatinine both demented ( n = 295) non‐demented other psychiatric disorders 215). were patients, whereas only had lower...
Abstract Objectives To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. Method The status was evaluated by measuring plasma homocysteine, serum methylmalonic acid, cobalamin and blood folate. Thirty‐three were studied repeatedly assessed Mini‐Mental State Examination (MMSE) ‘A short performance test for assessing memory attention’ (SKT) during vitamin substitution. Results Patients mild–moderate dementia elevated homocysteine...
Abstract Neurodegenerative diseases likely share common underlying pathobiology. Although prior work has identified susceptibility loci associated with various dementias, few, if any, studies have systematically evaluated shared genetic risk across several neurodegenerative diseases. Using genome-wide association data from large (total n = 82,337 cases and controls), we utilized a previously validated approach to identify overlap reveal pathways between progressive supranuclear palsy (PSP),...
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies highly effective at reducing vertebral but not fractures. Cortical bone is a major determinant of strength. To identify novel drug targets, we phenotyped cortical 3 366 viable mouse strains with global knockouts druggable genes. thickness was substantially elevated in Notum-/- mice. NOTUM secreted WNT lipase observed high expression osteoblasts osteoclasts. Three...
The frequency and characteristics of aggressive hostile behavior in 40 psychogeriatric inpatients was investigated using the Staff Observation Aggression Scale (SOAS). Most acts were directed towards nursing staff when providing help with activities daily living. A positive correlation found between age behavior, while severity most strongly correlated to length admission. significant decrease observed during six weeks observation. causes this are discussed together implications for future...
Probiotic bacteria can protect from ovariectomy (ovx)-induced bone loss in mice.
WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation WNTs by Porcupine required for activity. inhibitors are under development cancer therapy. As possible side effects on health unknown, we determined their mass strength. Twelve-week-old C57BL/6N female mice were treated LGK974 (low dose = 3 mg/kg/day; high 6 mg/kg/day) or Wnt-C59 (10 vehicle weeks. Bone parameters assessed serum biomarkers, dual-energy X-ray absorptiometry, µCT...
Abstract With increasing age of the population, countries across globe are facing a substantial increase in osteoporotic fractures. Genetic association signals for fractures have been reported at RSPO3 locus, but causal gene and underlying mechanism unknown. Here we show that fracture reducing allele locus associate with increased expression both mRNA protein levels, trabecular bone mineral density reduced risk mainly distal forearm humans. We also demonstrate is expressed osteoprogenitor...
Global sclerostin inhibition reduces fracture risk efficiently but has been associated with cardiovascular side effects. The strongest genetic signal for circulating is in the B4GALNT3 gene region, causal unknown. expresses enzyme beta-1,4-N-acetylgalactosaminyltransferase 3 that transfers N-acetylgalactosamine onto N-acetylglucosaminebeta-benzyl on protein epitopes (LDN-glycosylation).To determine if gene, B4galnt3-/- mice were developed and serum levels of total LDN-glycosylated analysed...
Cobalamin/folate deficiency in elderly subjects may lead to psychiatric symptoms, but more often it increases the severity of various organic and nonorganic mental diseases. A major clinical problem, however, is uncertainty controversy concerning biochemical markers cobalamin/folate be used diagnostic evaluation suspected deficiency.We measured plasma homocysteine (tHcy), blood folate, serum methylmalonic acid, cobalamin 80 psychogeriatric patients (age, 77.3 +/- 8.6 years) 50 controls 76.1...
Abstract Plasma homocysteine, serum cobalamin and blood folate were analysed in 296 consecutive patients referred to a psychogeriatric department for diagnosis of mental disease. homocysteine correlated with positive significance age creatinine, negative folate. Approximately 35–40% the low (<150 pmol l ‐1 ) or folates nmol exhibited normal values plasma (<19·9 μ mol ). Possibly, these do not have deficiency vitamins tissue. At least 7·5% levels (>150 showed an inexplicably...
Substantial progress has been made in the therapeutic reduction of vertebral fracture risk patients with osteoporosis, but non-vertebral improved only marginally. Human genetic studies demonstrate that WNT16 locus is a major determinant cortical bone thickness and mouse models life-long Wnt16 inactivation revealed key regulator thickness. These studies, however, could not exclude effect on might be caused by early developmental and/or growth effects. To determine specifically adult...
Osteoporosis is a common skeletal disease, affecting millions of individuals worldwide. Currently used osteoporosis treatments substantially reduce vertebral fracture risk, whereas nonvertebral mainly caused by reduced cortical bone mass, has only moderately been improved the drugs used, defining an unmet medical need. Because several wingless-type MMTV integration site family members (WNTs) and modulators WNT activity are major regulators we hypothesized that NOTUM, secreted lipase, might...
Bone mass and lean decrease with age these changes are associated increased fracture risk sarcopenia. Previous studies demonstrated that a probiotic mixture of Lacticaseibacillus paracasei DSM13434, Lactiplantibacillus plantarum DSM 15312 15313 (L. Mix) prevents bone loss in ovariectomized (ovx) female mice. The purpose the present study is to test if beneficial effect L. Mix modified by diet. Female mice were fed either high-fat (HFD, 60% kcal from fat) or low-fat (LFD, 10% diet subjected...
Neurochemical evidence indicates that cognitive impairment in dementia of Alzheimer type (DAT) is related to degeneration cholinergic neurons the brain. A pharmacological approach treatment with a cholinesterase inhibitor such as tetrahydroaminoacridine (THA). THA 17 patients DAT was studied double-blind crossover design three types treatment, + lecithin, placebo and placebo. Each period 6 weeks wash out periods 2 weeks. The evaluated clinical ratings, psychometric testing, EEG regional...
Objectives Frontotemporal dementia (FTD) is considered to be a mainly early-onset neurodegenerative disorder with strong hereditary component. The aim of the study was investigate age-related incidence and family history in FTD compared other disorders, especially Alzheimer's disease (AD). Methods Swedish Dementia Registry (SveDem) registers all new cases diagnosed by participating centres, including data on demographics, diagnosis, investigations used. Data for period 2008–2011 were...