A5068276403- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Treatment of Major Depression
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- RNA Research and Splicing
- Stress Responses and Cortisol
- Neurological disorders and treatments
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Health and Medical Research Impacts
- Medical Imaging Techniques and Applications
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Advanced Chemical Sensor Technologies
King's College London
2019-2025
University College London
2023-2024
University of Surrey
2019
Abstract Background Psychosis-relevant preclinical studies have demonstrated GABAergic drugs such as benzodiazepines can downregulate hippocampal hyperactivity and prevent the emergence of psychosis- like phenotypes. However, whether reduce normalise increased resting cerebral blood flow (rCBF) observed in individuals at clinical high-risk for psychosis (CHR-P) remains unknown. Aims To determine an acute dose diazepam subfield rCBF CHR-P individuals. Methods We conducted a within-subject,...
Disrupted gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of schizophrenia. Reductions in hippocampal GABAergic neurons have been found schizophrenia, and increased perfusion has described schizophrenia people at clinical high-risk for psychosis (CHRp). We also decreases GABA A receptors containing α 5 subunit (GABA α5) a well-validated neurodevelopmental rat model relevance Positive allosteric modulation these hippocampus using specific compound was...
Abstract Background Elevated hippocampal perfusion has been observed in people at clinical high-risk for psychosis (CHR-P). Preclinical evidence suggests that hyperactivity is central to the pathophysiology of psychosis, and prophylactic treatment with diazepam during adolescence can prevent development psychosis-relevant phenotypes. Here we examined whether normalises CHR-P individuals. Methods Using a randomised, double-blind, placebo-controlled, crossover design, 24 individuals were...
Elevated hippocampal perfusion has been observed in people at clinical high risk for psychosis (CHR-P). Preclinical evidence suggests that hyperactivity is central to the pathophysiology of psychosis, and peripubertal treatment with diazepam can prevent development psychosis-relevant phenotypes. The present experimental medicine study examined whether normalize CHR-P individuals. Using a randomized, double-blind, placebo-controlled, crossover design, 24 individuals were assessed magnetic...
Abstract Anxiety involves the anticipation of aversive outcomes and can impair neurocognitive processes, such as ability to recall faces encoded during anxious state. It is important precisely delineate determine replicability these effects using causal state anxiety inductions in general population. This study therefore aimed replicate prior research on distinct impacts threat-of-shock-induced encoding recognition stage emotional face processing, a large asymptomatic sample ( n = 92). We...
Selective serotonin reuptake inhibitors (SSRIs) are used for the treatment of several conditions including anxiety disorders, but basic neurobiology function remains unclear. The amygdala and prefrontal cortex strongly innervated by serotonergic projections have been suggested to play an important role in expression. However, behaviour SSRI-mediated neurobiological changes remain incompletely understood.
Abstract Diverse GABAergic interneuron networks orchestrate information processing in the brain. Understanding principles underlying organisation of this system human brain, and whether these are reflected by available non-invasive vivo neuroimaging methods, is crucial for study neurotransmission. Here, we use gene expression data state-of-the-art imaging transcriptomics to uncover co-expression patterns between genes encoding GABA A receptor subunits inhibitory subtype-specific markers,...
Abstract Background Preclinical evidence suggests that diazepam enhances hippocampal γ-aminobutyric acid (GABA) signalling and normalises a psychosis-relevant cortico-limbic-striatal circuit. Hippocampal network dysconnectivity, particularly from the CA1 subfield, is evident in people at clinical high-risk for psychosis (CHR-P), representing potential treatment target. This study aimed to forward-translate this preclinical evidence. Methods In randomised, double-blind, placebo-controlled...
Preclinical evidence suggests that modulating neural excitation through diazepam administration, a positive allosteric modulator of GABA A receptors, can prevent the emergence behavioural and neurobiological alterations relevant to psychosis in adulthood. Here, we examined this neurochemical mechanism individuals at clinical high-risk for (CHRp) randomised, double-blind, placebo-controlled crossover study. Twenty-four aged 18-35 were scanned twice using proton magnetic resonance spectroscopy...
Abstract Diverse GABAergic interneuron microcircuits orchestrate information processing in the brain. Understanding cellular and molecular composition of these microcircuits, whether can be imaged by available non-invasive vivo methods is crucial for study neurotransmission health disease. Here, we use human gene expression data state-of-the-art imaging transcriptomics to uncover co-expression patterns between GABA A receptor subunits subtype-specific markers, decode signatures gold-standard...
Abstract Background Impaired emotion processing constitutes a key dimension of schizophrenia and possible endophenotype this illness. Empirical studies consistently report poorer recognition performance in patients with as well individuals at enhanced risk (“at risk”). fMRI also consistent patterns abnormal brain activation response to emotional stimuli patients, particular decreased amygdala activation. In contrast, brain-level abnormalities at-risk are more elusive. We address gap using an...