PULSAR Effect: Revealing Potential Synergies in Combined Radiation Therapy and Immunotherapy via Differential Equations

• DOI: 10.48550/arxiv.2402.06101
• Publication Date: 2024-02-08
• Authors: Samiha Rouf; Casey Moore; Debabrata Saha; Dan Nguyen; MaryLena Bleile; Robert Timmerman; Hao Peng; Steve Jiang
• Keywords: Differential treatment

PULSAR (personalized ultrafractionated stereotactic adaptive radiotherapy) is a form of radiotherapy method where patient given large dose or pulse radiation couple weeks apart rather than daily small doses. The tumor response then monitored to determine when the subsequent should be given. Pre-clinical trials have shown better in mice that received immunotherapy along with pulses spaced 10 days apart. However, this was not case were 1 day Therefore, synergistic effect between and observed are out by certain number days. In our study, we aimed develop mathematical model can capture considering time-dependent weight function takes into account spacing pulses. By determining feasible parameters, applying reasonable conditions, utilize simulate murine varying sequencing We successfully demonstrate simple implement generate volume data consistent pre-clinical trial data. Our has potential aid development clinical therapy.