A5013645349- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Curcumin's Biomedical Applications
- Effects of Radiation Exposure
- Radiomics and Machine Learning in Medical Imaging
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- AI in cancer detection
- Cancer Immunotherapy and Biomarkers
- Fatty Acid Research and Health
- Solar Radiation and Photovoltaics
- Advanced Radiotherapy Techniques
- Nuclear Receptors and Signaling
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Spaceflight effects on biology
- Biochemical effects in animals
- Photovoltaic Systems and Sustainability
- Biofield Effects and Biophysics
- Energy and Environment Impacts
- Infrared Thermography in Medicine
- Gene expression and cancer classification
- Genetics, Aging, and Longevity in Model Organisms
- Radiation Therapy and Dosimetry
Texas Tech University
2020-2024
Memorial Sloan Kettering Cancer Center
2024
Obesity prevalence continues to increase and contribute metabolic diseases, potentially by driving systemic inflammation. Curcumin is an anti-inflammatory spice with claimed health benefits. However, mechanisms which curcumin may reduce obesity-associated inflammation are poorly understood; thus, it hypothesized that benefits of consumption occur through reduced white adipose tissue (WAT) and/or beneficial changes in gut bacteria.Male B6 mice fed high-fat diets (HFD, 45% kcal fat) or HFD...
Multiplex immunofluorescence (mIF) is a promising tool for immunotherapy biomarker discovery in melanoma and other solid tumors. mIF captures detailed phenotypic information of immune cells the tumor microenvironment, as well spatial data that can reveal biologically relevant interactions among cell types. Given complexity data, development automated analysis pipelines crucial advancing discovery. In pre-treatment samples from 50 patients treated with checkpoint inhibitors (ICIs), higher...
Obesity is a complex disease of global epidemic proportions. Adipose tissue expansion and chronic low-grade inflammation, locally systemically, are hallmark features obesity. associated with several other diseases, which also characterized by inflammation. Determination adipocyte size macrophage content in adipose critical step assessing changes this Here, we introduce complete standalone software package, AdipoGauge, to analyse microscopic images derived from haematoxylin eosin...
SUMMARY Quantitative assessment of multiplex immunofluorescence (mIF) data represents a powerful tool for immunotherapy biomarker discovery in melanoma and other solid tumors. In addition to providing detailed phenotypic information immune cells the tumor microenvironment, these datasets contain spatial that can reveal biologically relevant interactions among cell types. To assess quantitative mIF analysis as platform discovery, we used 12-plex panel characterize samples collected from 50...
Worldwide rates of Western-diet-induced obesity epidemics are growing dramatically. Being linked with numerous comorbidities and complications, including cardiovascular disease, type 2 diabetes, cancer, chronic inflammation, osteoarthritis (OA), represents one the most threatening challenges for modern healthcare. Mouse models an invaluable tool investigating effects diets their bioactive components against high fat diet (HFD)-induced its comorbidities. During recent years, very (VHFDs),...
The renewable energy production continues to accelerate as the world recognizes negative impact of fossil fuel consumption on environment. Among technologies, there has been rapid growth in use solar PV systems last two decades. technology widely used provide green and sustainable both single households various institutions. Researchers educational institutions are currently attracted by this it is economically competitive with conventional forms electricity generation. aim study design...
Detection of tumor-infiltrating lymphocytes (TILs) in cancer images has gained significant importance as these can be used a biomarker detection and treatment procedures. Our goal was to develop apply TILs tool that utilizes deep learning models, following two sequential steps. First, based on the guidelines from International Immuno-Oncology Biomarker Working Group (IIOBWG) Breast Cancer, we labeled 63 large pathology imaging slides annotated stroma area create dataset required for model...
Abstract The multiplexed immunofluorescence (mIF) platform enables biomarker discovery through the simultaneous detection of multiple markers on a single tissue slide, offering detailed insights into intratumor heterogeneity and tumor-immune microenvironment at spatially resolved cell resolution. However, current mIF image analyses are labor-intensive, requiring specialized pathology expertise which limits their scalability clinical application. To address this challenge, we developed...
Much of the complex medical physics work requires radiation dose delivery, which dosimeters to accurately measure three-dimensional distribution with good spatial resolution. MAGIC-f polymer gel is one emerging new widely used in research. The purpose this study was present an overview dosimetry, using gel, including its composition, manufacture, imaging, calibration, and application In review, history development presented, along applications so far. Moreover, most important...
External exposure to skin from beta-emitter radionuclides following severe reactor accidents or nuclear testing can result in beta burning and other health complications. The absorbed dose coefficient (SADC) measures the energy deposition into during such accidents. U.S. Environmental Protection Agency has published several reports measure possible However, most recent SADC by Federal Guidance Report (FGR) 12 was computed only at one meter above contaminated surface. Therefore, it necessary...
Recent progress in multiplexed tissue imaging is advancing the study of tumor microenvironments to enhance our understanding treatment response and disease progression. Cellular neighborhood analysis a popular computational approach for these complex image data. Despite its popularity, there are significant challenges, including high demands that limit feasibility large-scale applications lack principled strategy integrative across images. This absence hampers precise consistent...
<title>Abstract</title> Mitochondrial glycerol-3-phosphate dehydrogenase (GPD2) is crucial enzyme in the glycerophosphate shuttle, linking glycolysis, lipogenesis, and oxidative phosphorylation, making it a potential target for obesity treatment. We previously found that eicosapentaenoic acid (EPA), an omega-3 fatty acid, increased oxidation GPD2 expression uncoupling protein 1 (UCP1) deficient mice. Here, utilizing Gpd2 knockout (KO) mice, we hypothesized EPA mediates GPD2-centered shuttle...
Higher intake of saturated fats, salts, and fatty proteins has been linked to metabolic diseases (e.g., obesity), in part through low-grade acidosis inflammation. Hence, our objective was test the effects protein sources preparations diet induced obese B6 male female mice, compared low fat-fed mice. We hypothesized that health will be improved by consuming a containing pH-enhanced beef or casein diets, non-pH-enhanced diets. mice were randomized (n = 10) into 8 diets differ source, pH...