A5030856153- Cutaneous Melanoma Detection and Management
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- AI in cancer detection
- melanin and skin pigmentation
- Autoimmune and Inflammatory Disorders
- Oral Health Pathology and Treatment
- Genetic and rare skin diseases.
- Radiomics and Machine Learning in Medical Imaging
- Eosinophilic Disorders and Syndromes
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Nail Diseases and Treatments
- Psoriasis: Treatment and Pathogenesis
- Cell Image Analysis Techniques
- Hidradenitis Suppurativa and Treatments
- Melanoma and MAPK Pathways
- Drug-Induced Adverse Reactions
- Chemotherapy-related skin toxicity
- CAR-T cell therapy research
- Tumors and Oncological Cases
- Skin and Cellular Biology Research
- Dermatological diseases and infestations
- Acne and Rosacea Treatments and Effects
University of North Carolina at Chapel Hill
2010-2024
Eastern Virginia Medical School
2024
Medical University of South Carolina
2021
University of North Carolina Hospitals
2021
Michigan Medicine
2018
University of Michigan–Ann Arbor
2018
University of Sioux Falls
2014
University of South Dakota
2014
Reduced β-cell function and insulin deficiency are hallmarks of diabetes mellitus, which is often accompanied by the malfunction glucagon-secreting α-cells. While therapy has been developed to treat deficiency, on-demand supplementation glucagon for acute hypoglycemia treatment remains inadequate. Here, we describe a transdermal patch that mimics inherent counterregulatory effects β-cells α-cells blood glucose management dynamically releasing or glucagon. The two modules share copolymerized...
In their 2018 article, Lezcano et al [AJSP 2018(11):1456] show that diffuse tumor cell nuclear reactivity for Preferentially expressed Antigen in Melanoma (PRAME) is a feature of melanoma and benign atypical melanocytic tumors are PRAME negative or only focal positivity PRAME. We report our observations staining 253 tumors. Tumors were classified by hematoxylin eosin sections. The neoplastic melanocytes each case was categorized as absent, focally present, diffusely present. results compared...
Miedema J, Marron J S, Niethammer M, Borland D, Woosley Coposky Wei Reisner H & Thomas N E (2012) Histopathology 61, 436–444 Image and statistical analysis of melanocytic histology Aims: We applied digital image techniques to study selected types lesions. Methods results: used advanced compare lesions as follows: (i) melanoma nevi, (ii) subtypes (iii) severely dysplastic nevi other (iv) nevi. were successful in differentiating from [receiver operating characteristic area (ROC) 0.95]...
Abstract The multiplexed immunofluorescence (mIF) platform enables biomarker discovery through the simultaneous detection of multiple markers on a single tissue slide, offering detailed insights into intratumor heterogeneity and tumor-immune microenvironment at spatially resolved cell resolution. However, current mIF image analyses are labor-intensive, requiring specialized pathology expertise which limits their scalability clinical application. To address this challenge, we developed...
Abstract We recently saw the case of an 8‐year‐old boy with histologic findings spiradenocarcinoma. Malignant adnexal tumors in children are exceedingly rare, and cases spiradenocarcinoma absent literature. report metastatic A biopsy 2 years before his presentation at our institution was interpreted as a benign lesion, but when lesion regrew, repeat performed that demonstrated ominous findings, prompting reexcision. This reexcision area significant necrosis, many mitoses, cellular...
Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse characterized by morbilliform eruption, fever, lymphadenopathy, multiorgan involvement. Alopecia universalis variant of alopecia areata complete loss hair on the entire body. Herein, we report case that presented after DRESS.
To the Editor: Recent years have seen increased interest in programmed cell death protein 1 (PD-1)/PD-1 to its ligand (PD-L1) pathway. This pathway, when activated, suppresses immune system while inhibition promotes upregulation, a feature which forms mechanismal basis for several new drugs used treatment of melanoma and other types malignancy. We at our institution 3 cases Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) context PD-1 inhibitor therapy. Using lichen planus as...
Cutaneous lupus erythematosus (CLE) and lichen planus (LP) are considered skin disease processes with distinct pathogenic mechanisms, clinical features, histologic findings, courses. However, there exists a rare disorder termed CLE/LP overlap syndrome that has been inconsistently reported in the literature due to absence of clear diagnostic criteria, most reports involving cases coexisting or overlapping features CLE LP.1-3 In this article, we report 2 syndrome, propose criterion for briefly...
Sadeghi, Nakisa B. MD, MPH; Ziemer, Carolyn M. Wu, Sam MD; Miedema, Jayson R. Blasiak, Rachel C. MPH Author Information
Sadeghi, Nakisa B. MD, MPH; Ziemer, Carolyn M. Wu, Sam MD; Miedema, Jayson R. Blasiak, Rachel C. MPH Author Information
Melanoma with lymphatic invasion has been associated increased risk of metastasis, but the mechanisms and clinical implications are poorly understood. Although current reports have documented angiotropic spread melanoma suggest to increase likelihood our knowledge, lymphangitic metastatic resembling cutaneous carcinomatosis or presenting facial hyperpigmentation not described. In this case report, we describe extensive intralymphatic melanoma, melanomatosis, producing macular skin...
Cutaneous sarcomatoid squamous cell carcinoma is well-described with histology resembling pleomorphic undifferentiated sarcoma featuring collagenous or myxoid stroma without elements of keratinizing carcinoma. This report presents 2 cases dedifferentiated (SCC) composed sheets malignant mononuclear cells osteoclast-like multinucleated giant cells, extravasated blood, and hemosiderin cutaneous tumor (cGCT). In the first case, an exophytic facial mass a 96-year-old woman removed by shave...