A5068146420- Polyomavirus and related diseases
- Cutaneous Melanoma Detection and Management
- Molecular Biology Techniques and Applications
- Bacteriophages and microbial interactions
- Heat shock proteins research
- Plant Virus Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Nonmelanoma Skin Cancer Studies
- Antenna Design and Analysis
- CAR-T cell therapy research
- Melanoma and MAPK Pathways
- Cancer and Skin Lesions
- Immunotherapy and Immune Responses
- Optical Coherence Tomography Applications
- Computational Drug Discovery Methods
- Ear and Head Tumors
- Hedgehog Signaling Pathway Studies
- Cancer Genomics and Diagnostics
- Full-Duplex Wireless Communications
- Skin Protection and Aging
- melanin and skin pigmentation
- Cancer Research and Treatments
- Cutaneous lymphoproliferative disorders research
- Dermatologic Treatments and Research
- Cell Image Analysis Techniques
Michigan Medicine
2016-2024
Biomed Research Institute
2023
University of Michigan
2014-2023
A. Alfred Taubman Health Care Center
2020-2022
Michigan Center for Translational Pathology
2016-2021
Michigan United
2021
Over the past few years, NCCN Guidelines for Melanoma: Cutaneous have been expanded to include pathways treatment of microscopic satellitosis (added in v2.2020), and following Principles sections: Molecular Testing v2.2019), Systemic Therapy Considerations Brain Metastases Management v3.2020). The v1.2021 update included additional modifications these sections notable revisions of: Pathology, Surgical Margins Wide Excision Primary Melanoma, Sentinel Lymph Node Biopsy, Completion/Therapeutic...
Melanoma is among the most aggressive cancers, and its rate of incidence continues to grow. Early detection melanoma has been hampered due lack promising markers for testing. Recent advances in liquid biopsy have proposed noninvasive alternatives cancer diagnosis monitoring. Circulating tumor cells (CTCs) cancer-exosomes are gaining influence as biomarkers because their cancer-associated molecular signatures. However, technologies that offer dual-isolation CTCs exosomes using a single sample...
Melanoma arising in chronically photodamaged skin, especially on the head and neck, is often characterized by poorly defined clinical margins unpredictable occult extension. Staged excision techniques have been described to treat these challenging melanomas.To investigate local recurrence rates margin clearance end points using staged with comprehensive hematoxylin-eosin-stained permanent section control.In this observational cohort study performed from October 8, 1997, December 31, 2006, a...
The NCCN Guidelines for Uveal Melanoma include recommendations staging, treatment, and follow-up of patients diagnosed with uveal melanoma the choroid or ciliary body. In addition, because distinguishing between benign nevi is in some cases difficult, these guidelines also contain workup suspicious pigmented lesions, to clarify tests needed distinguish those who should have further treatment versus uncertain diagnosis low risk be followed later reevaluated. These Insights describe newly...
Abstract ETS transcription factors are commonly deregulated in cancer by chromosomal translocation, overexpression or post-translational modification to induce gene expression programs essential tumorigenicity. Targeted destruction of these proteins may have therapeutic impact. Here we report that Ets-1 is regulated the deubiquitinating enzyme, Usp9x, and has major impact on tumorigenic program metastatic melanoma. deubiquitination blocks its proteasomal enhances tumorigenicity, which could...
Metastasis of cutaneous squamous cell carcinoma (SCC) to the nodal basin is associated with a poor prognosis. The role sentinel lymph node biopsy (SLNB) for regional staging in patients diagnosed SCC unclear.To evaluate single institution's experience use SLNB on head and neck.A retrospective review 53 who were neck, at high risk metastasis based National Comprehensive Cancer Network (NCCN) factors, treated wide local excision (WLE) from December 1, 2010, through January 30, 2015, academic...
Abstract Background Basal cell carcinoma (BCC) is a common skin cancer often curable by excision; however, for patients with BCC around the eye, excision places visual organs and function at risk. In this article, we test hypothesis that use of hedgehog inhibitor vismodegib will improve vision-related outcomes in orbital extensive periocular (opBCC). Materials Methods open-label, nonrandomized phase IV trial, enrolled globe- lacrimal drainage system–threatening opBCC. To assess context...
The protection of telomeres 1 protein (POT1) is a critical component the shelterin complex, multiple-protein machine that regulates telomere length and protects ends. Germline variants in POT1 have been linked to familial melanoma, somatic mutations are associated with range cancers including cutaneous T-cell lymphoma (CTCL).
Purpose: Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine tumor of the skin. polyomavirus (MCPyV) plays an oncogenic role in majority MCCs. Detection MCPyV MCCs has diagnostic utility and prognostic potential. We investigated whether RNAscope, RNA situ hybridization (ISH) assay for detection transcripts tissues, useful detection.Experimental Design: applied RNAscope probe targeting T antigen on tissue microarrays (TMA) whole-tissue sections encompassing 87 from 75 patients,...
The publication of MSLT-II shifted recommendations for management sentinel lymph node biopsy positive (SLNB+) melanoma to favor active surveillance. We examined trends in immediate completion dissection (CLND) following MSLT-II.Using a prospective database at high-volume center, we identified cohort consecutive SLNB+ patients from July 2016 April 2019. Patient and disease characteristics were analyzed with multivariate logistic regression examine factors associated CLND.Two hundred...
Abstract Background The primary purpose of this study was to describe the parotid recurrence rates after superficial and total parotidectomy. Methods A retrospective cohort performed on patients with cutaneous melanoma metastatic gland who underwent parotidectomy from 1998 through 2014. Primary outcome bed recurrence. Secondary outcomes were facial nerve function postoperatively at last follow‐up. Results One hundred twenty‐nine included in study. Thirty‐four (26%) a 95 Twelve (13%)...
Current literature may overestimate the risk of nodal metastasis from thin melanoma due to reporting data only lesions treated with SLNB. Our objective was define natural history melanoma, assessing likelihood disease, in order guide selection for SLNB.Retrospective review. The primary outcome rate disease. Clinicopathologic factors were evaluated find associations disease.Five hundred and twelve lesions, follow up available 488 (median: 48 months). Lesions WLE/SLNB compared WLE alone more...
Despite being the leading cause of cancer deaths, metastasis remains a poorly understood process. To identify novel regulators in melanoma, we performed large-scale RNA sequencing screen 48 samples from patient-derived xenograft (PDX) subcutaneous melanomas and their associated metastases. In comparison with primary tumors, expression glycolytic genes was frequently decreased metastases, whereas some tricarboxylic acid (TCA) cycle increased Consistent these transcriptional changes, melanoma...
// Harish Potu 1 , Malathi Kandarpa Luke F. Peterson Alison Durham 2 Nicholas J. Donato 3 * and Moshe Talpaz Department of Internal Medicine/Division Hematology/Oncology, University Michigan, School Medicine Comprehensive Cancer Center, Ann Arbor, MI 48109, USA Dermatology, Michigan Medicine, Center for Scientific Review, National Institutes Health, Bethesda, MD 20892, These authors jointly supervised this work Correspondence to: Talpaz, email: mtalpaz@med.umich.edu Keywords: melanoma;...
The diagnosis and management of pediatric melanomas is challenging given the presence both histologically aggressive Spitz tumors undetermined biological significance (S-UBS) in this age group. Study objectives were to examine: factors leading diagnostic delays, therapy side effects patient outcomes these groups.A retrospective case review was performed using University Michigan's oncology database over a 13-year timespan. Patients referred our clinic for consideration interferon due stage...