A5053100564- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Vascular Tumors and Angiosarcomas
- Sarcoma Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Nonmelanoma Skin Cancer Studies
- Ocular Oncology and Treatments
- Cutaneous lymphoproliferative disorders research
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Gastrointestinal disorders and treatments
- CAR-T cell therapy research
- Brain Metastases and Treatment
- Oral Health Pathology and Treatment
- Cancer therapeutics and mechanisms
- Tumors and Oncological Cases
- Urologic and reproductive health conditions
- Soft tissue tumor case studies
- Chemotherapy-related skin toxicity
- Vascular Malformations and Hemangiomas
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Nail Diseases and Treatments
University of Michigan
2019-2025
Michigan Medicine
2019-2024
U-M Rogel Cancer Center
2023
Michigan Center for Translational Pathology
2021-2022
Brigham and Women's Hospital
2016
Harvard University
2016
University of Pennsylvania
2011-2014
Inserm
2012
Sorbonne Université
2012
Neuroblastoma sensitivity to crizotinib depends on the ATP-binding affinity of ALK variants, suggesting that higher doses may overcome resistance.
Preferentially expressed antigen in melanoma (PRAME) is an immunohistochemical biomarker that diffusely most cutaneous melanomas and negative benign nevi. Histologically challenging dermal melanocytic neoplasms, such as cellular blue nevi (CBN) deep penetrating (DPN), soft tissue tumors with differentiation, clear cell sarcoma perivascular epithelioid tumor, may resemble primary or metastatic melanoma. PRAME immunohistochemistry (IHC) was applied to archived formalin-fixed, paraffin-embedded...
Abstract Background Basal cell carcinoma (BCC) is a common skin cancer often curable by excision; however, for patients with BCC around the eye, excision places visual organs and function at risk. In this article, we test hypothesis that use of hedgehog inhibitor vismodegib will improve vision-related outcomes in orbital extensive periocular (opBCC). Materials Methods open-label, nonrandomized phase IV trial, enrolled globe- lacrimal drainage system–threatening opBCC. To assess context...
Diagnosis of spindle cell/sarcomatoid melanoma may be challenging due to frequent loss expression melanocytic marker(s) and histomorphologic resemblance various mesenchymal tumours, particularly malignant peripheral nerve sheath tumour (MPNST). Overexpression PReferentially expressed Antigen in MElanoma (PRAME) supports a diagnosis when evaluating tumours. PRAME MPNST other cutaneous sarcomatoid neoplasms, however, has not been well characterised. We aimed determine the utility immunostain...
ABSTRACT Liposarcoma (LPS) is the most prevalent soft tissue sarcoma. The common biological subtypes are well-differentiated (WDLPS), a low-grade disease that can evolve to high-grade dedifferentiated LPS (DDLPS), with increased rates of recurrence and metastasis low response chemotherapy targeted therapies. Preclinical testing immunotherapeutics for has been held back by lack an immunocompetent mouse model. Here, we present spontaneous model, ACPP, deletion Trp53 Pten in adipocytes mimic...
Aims BAP1‐inactivated melanocytic tumours (BIMTs) occur sporadically and in association with a familial tumour predisposition syndrome involving germline mutations the BRCA1‐associated protein‐1 ( BAP1 ) gene. Here we report clinical features, histopathologic findings, chromosomal copy number data of 19 melanocytomas (BIMs) compare their features to those five melanomas. Methods We retrospectively searched Department Pathology archives EMERSE (Electronic Medical Record Search Engine) for...
PReferentially expressed Antigen in MElanoma (PRAME) is a cancer-testis antigen upregulated multitude of human neoplasms, while minimally normal adult tissues except germ cells.1 The PRAME immunostain has gained interest recent years, particularly the realm diagnostically challenging melanocytic lesions. Large cohorts have shown diffuse expression 80%–83% all melanomas; on other hand, benign nevi showed little to absent expression.2-6 Unlike most types melanoma, however, only minority...
Abstract Background Porocarcinomas are rare aggressive carcinomas that harbor tumor suppressor mutations and must be distinguished from benign entities such as poromas. Methods To determine whether altered expression of these genes was diagnostically informative, we examined p53, Rb, p16 staining patterns in 15 poromas 16 porocarcinomas. Results Poromas consistently displayed diffuse strong Rb all but one case focal loss (1/15, 7%), no evidence aberrancy p53 or p16. 9/16 (56%) cases,...
Context.— Conjunctival melanocytic lesions consist of a variety neoplastic and nonneoplastic conditions. These include benign processes such as primary intraepithelial hypermelanosis hyperplasia, secondary forms nevi, proliferations with malignant potential, melanoma. Objective.— To provide concise yet comprehensive resource regarding the histopathologic diagnosis conjunctival lesions. We aim to detail clarify numerous classification schemes that exist for junctional conjunctiva (known...
Hypertrophic lichen planus (HLP) is a variant of that can be difficult to diagnose based on histopathologic features alone. Thus, patient clinical history and clinicopathologic correlation are essential considerations make the correct diagnosis.
5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker detectable through immunohistochemistry (IHC) that has been shown to distinguish benign nevi from melanoma with high sensitivity and specificity. The purpose of the study was explore its diagnostic utility in a subset histologically challenging, heavily pigmented cutaneous melanocytic neoplasms.5-hmC IHC performed on 54 tumors. Semi-quantitative analysis immunoreactivity correlated clinical, pathologic follow-up data.Benign neoplasms (4...
Iododerma is a rare halogenoderma that develops after exposure to iodine-containing compounds. Three cases of iododerma in patients who had recent intravenous iodinated contrast media and confirmed elevated urine iodine levels are presented. These serve illustrate lesions can be heterogeneous, progress rapidly, frequently have hemorrhagic component, all which cause clinical concern for disseminated infection, neutrophilic dermatosis, or vasculitis. In addition, skin biopsies demonstrated...
Conjunctival melanocytic proliferations are diagnostically challenging, often complicated by small specimen size, and separated into 3 broad categories. The first group includes benign nevi primary acquired melanosis (PAM) without atypia. second junctional with a risk of progression to invasive melanoma (PAM atypia). last category is conjunctival melanoma, which 65% tumors arise in the setting PAM Preferentially expressed antigen (PRAME) immunohistochemistry has been widely adopted...
COVID-19 infection and vaccination may be associated with a wide variety of cutaneous immune manifestations. Here, we describe two patients who presented monoclonal T-cell infiltrates that showed cytologic immunophenotypic features concerning for lymphoma shortly following vaccination. In one case, the eruption completely resolved. The second patient initial resolution, but her disease recurred progressed breakthrough SARS-CoV-2 infection. These cases suggest stimulation exposure to...
Abstract Objectives Oral autoimmune bullous disorders show clinical overlap with diseases such as lichen planus and others that may cause desquamative gingivitis. As direct immunofluorescence is expensive, we sought to determine if routine histology alone would be sufficient distinguish between oral mimics. Methods We searched the records for patients a suspected disorder who underwent biopsies concurrent histologic evaluation had at least one follow‐up visit. Cases were separated into high...
Primary cutaneous T-cell lymphoma (CTCL) comprises a heterogeneous group of neoplasms with variable clinical behavior. Immunophenotypic switch (IS) is phenomenon that occurs during progression and defined by an alteration in the immunophenotypic expression tumor retention its genotypic signature. This has been well-recognized hematopoietic neoplasms; however, it rarely reported CTCL implications are not well understood. We present clinical, histopathologic, immunophenotypic, genetic findings...