A5078192152- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Nuclear Receptors and Signaling
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Obesity, Physical Activity, Diet
- Apelin-related biomedical research
- Manufacturing Process and Optimization
- Pharmacology and Obesity Treatment
- Vitamin D Research Studies
- Animal Diversity and Health Studies
- HIV-related health complications and treatments
- Alzheimer's disease research and treatments
- Cholesterol and Lipid Metabolism
- Biochemical effects in animals
- Macrophage Migration Inhibitory Factor
- Genetics, Aging, and Longevity in Model Organisms
- Spaceflight effects on biology
Texas Tech University
2019-2025
Harvard University
2024
Iran University of Medical Sciences
2018-2022
Tehran University of Medical Sciences
2006
Shiraz University
2005
Alzheimer's disease (AD) alters neurocognitive and emotional function causes dysregulation of multiple homeostatic processes. The leading AD framework pins amyloid beta plaques tau tangles as primary drivers dysfunction. However, many additional variables, including diet, stress, sex, age, pain tolerance, interact in ways that are not fully understood to impact the onset progression pathophysiology. We asked: (1) does high-fat compared low-fat exacerbate pathophysiology behavioral decline?...
Abstract Metastasis is the primary cause of breast cancer-related mortality, and understanding intricate relationship between tumor microenvironment, lipid metabolism, metastasis crucial for preventing cancer progression. Previous work from our group demonstrated that high exogenous levels oleic acid, a monounsaturated fatty acid (MUFA), in lymph node environment protects melanoma cells ferroptosis. Ferroptosis an iron-dependent form cell death induced by accumulation peroxides, which are...
Objective. To determine the relationship between serum vitamin A and E apolipoprotein levels in type 2 diabetic patients.Setting. Shariati Hospital, Tehran, Iran.Subjects methods. One hundred seventeen eligible patients who attended Endocrine Research Metabolism Center 2002 2004 were enrolled study. Blood samples collected after a 12 - 14-hour overnight fast for measurement of total cholesterol, triglyceride, high-density lipoprotein (HDL), low-density (LDL), (apo) A1 apoB, vitamins E....
Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by presence of amyloid plaques. Exact etiology treatment and early diagnosis still unknown not possible. Obesity an important risk factor disorders. Eicosapentaenoic acid (EPA), long-chain omega-3 polyunsaturated fatty exerts anti-inflammatory effects, but how EPA affects AD unknown. This study aims to determine whether supplementation improves overall metabolic status in transgenic APPswePS1E9 mouse model. Mice were...
Alzheimer's disease (AD) is the leading cause of dementia and characterized by accumulation amyloid-beta (Aβ) phosphorylated tau tangles. Obesity a complex disease, associated with inflammation, metabolic dysfunctions, risk factor for AD. Marine eicosapentaenoic acid (EPA), exerts beneficial effects on obesity inflammation in rodents. Our objective to determine diet-induced obese amyloidogenic mice, whether EPA reduces Aβ levels if so, through which transcriptional mechanisms. Male female...
Abstract Background Alzheimer’s disease (AD) is a progressive brain characterised by cerebral aggregation of amyloid beta (Aβ) plaques. Obesity chronic complex excessive fat accumulation, that associated with systemic and adipose tissue inflammation, may increase the risk for AD. Eicosapentaenoic acid (EPA) found in fish oil, an omega‐3 polyunsaturated fatty anti‐obesity anti‐inflammatory properties. In this study, we propose EPA supplementation will protect against AD‐associated metabolic...
Abstract Background Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder characterized by amyloid‐beta (Aβ) plaques, which may be exacerbated obesity. We previously reported anti‐obesity and anti‐inflammatory effects of eicosapentaenoic acid (EPA), in diet‐induced obese mice. Therefore, the objective this research to determine whether EPA also protects against AD‐associated Aβ deposition. Method Male female AD mouse model APPswePS1E9 transgenic (TG) non‐TG wild type...
Background: The prevalence of overweight and obesity is increasing among women. Since diet quality life are two indicators healthy lifestyle, we conducted this study to examine the relationship between these obese Methods: This was carried out a sample 111 women, aged 35-60 years in west Tehran, Iran. Dietary data were collected using 168-item food frequency questionnaire Nutrient-Rich Food index (NRF9.3) algorithms used estimate nutrient density. measured 26-item WHOQOL-BREF questionnaire....
Alzheimer's disease (AD) is a degenerative brain characterized by atypical development of amyloid-beta (Aβ) plaques. We previously showed that eicosapentaenoic acid (EPA), found in fish oil exerted anti-obesity and anti-inflammatory effects diet-induced obese (DIO) mice. Here we hypothesize EPA will reduce both adiposity neuroinflammation an amyloidogenic DIO mouse model. Two-month-old male female APPswePS1E9 transgenic (TG) non-TG littermates were randomly assigned to low fat (LF; 10% kcal...
Abstract Background Alzheimer’s disease (AD) is characterized by amyloid‐beta (Aβ) plaque deposition and may be exacerbated aging‐induced neuroinflammation obesity. We hypothesized that compared to high fat (HF) diets, FO with anti‐inflammatory anti‐obesity properties, would reduce metabolic cognitive dysfunctions in an AD amyloidogenic mouse model of Method Two‐month‐old, both sexes, APPswePS1E9 transgenic (TG) non‐TG littermates were randomly assigned fed low (LF), HF, or HF supplemented...