Chanaka Kahathuduwa

ORCID: 0000-0003-2049-4901
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About
Contact & Profiles
Research Areas
  • Eating Disorders and Behaviors
  • Functional Brain Connectivity Studies
  • Obesity, Physical Activity, Diet
  • Autism Spectrum Disorder Research
  • Diet and metabolism studies
  • Fatty Acid Research and Health
  • Child Nutrition and Feeding Issues
  • Biochemical Analysis and Sensing Techniques
  • Nutritional Studies and Diet
  • Genetics and Neurodevelopmental Disorders
  • Stroke Rehabilitation and Recovery
  • Advanced Neuroimaging Techniques and Applications
  • Olfactory and Sensory Function Studies
  • Sensory Analysis and Statistical Methods
  • COVID-19 and healthcare impacts
  • Acute Ischemic Stroke Management
  • Attention Deficit Hyperactivity Disorder
  • Adipose Tissue and Metabolism
  • Tea Polyphenols and Effects
  • Mind wandering and attention
  • Adipokines, Inflammation, and Metabolic Diseases
  • Otolaryngology and Infectious Diseases
  • COVID-19 Clinical Research Studies
  • Heart Rate Variability and Autonomic Control
  • Neurological disorders and treatments

Texas Tech University Health Sciences Center
2019-2025

Texas Tech University
2016-2025

Covenant Medical Center
2024

Integrative Health Technologies (United States)
2021

University of Peradeniya
2015-2020

Sleep is closely related to physical and mental health problems as well problem behaviors among adolescents young adults. Thus, better understand sleep seems paramount, including how best measure it. The Pittsburgh Quality Index (PSQI) one of the most widely used measures. Some recent psychometric evidence (i.e., inconsistent dimensionality across studies) has called into question application this clinically developed measure. current study sought rigorously test measure, by comparing a it...

10.1037/pas0001027 article EN Psychological Assessment 2021-05-20

Objective: l-theanine is a constituent of tea which claimed to enhance cognitive functions. We aimed determine whether theanine and theanine–caffeine combination have acute positive effects on neurophysiological measures attention, compared caffeine (a control) placebo in healthy individuals.

10.1080/1028415x.2016.1144845 article EN Nutritional Neuroscience 2016-02-12

Objective: A pre/post pilot study was designed to investigate neurobiological mechanisms and plasma metabolites in an 8-week Tai-Chi (TC) group intervention subjects with knee osteoarthritis. Methods: Twelve postmenopausal women underwent exercise for 8 weeks (60 min/session, three times/week). Outcomes were measured before after Tai Chi including pain intensity (VAS), Brief Pain Inventory (BPI), Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), (amino acids lipids), as...

10.3389/fmed.2021.775344 article EN cc-by Frontiers in Medicine 2022-01-03

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and behavioral changes. It poses significant global health challenge. AD associated with the accumulation of amyloid-β (Aβ) plaques neurofibrillary tangles (NFTs) in brain, along chronic inflammation, dysfunctional neurons, synapse loss. While prevalence continues to rise, current FDA-approved drugs offer only limited effectiveness. Emerging evidence suggests that...

10.3390/nu17071203 article EN Nutrients 2025-03-29

Calorie restriction via total meal replacement (TMR) results in greater reduction of food cravings compared to reduced-calorie typical diet (TD). Direct evidence the impact these interventions on human brain fMRI food-cue reactivity (fMRI-FCR) and functional connectivity is absent. We examined effects a 3-week 1120 kcal/d TMR intervention as an iso-caloric TD using fMRI-FCR paradigm. Thirty-two male female subjects with obesity (19–60 years; 30–39.9 kg/m2) participated randomized two-group...

10.1016/j.appet.2017.09.025 article EN cc-by-nc-nd Appetite 2017-09-25

Abstract We examined the acute effects of l -theanine, caffeine and their combination on sustained attention, inhibitory control overall cognition in boys with attention deficit hyperactivity disorder (ADHD). -Theanine (2.5 mg/kg), (2.0 a placebo were administered randomized four-way repeated-measures crossover washout, to five (8–15 years) ADHD. Functional magnetic resonance imaging (fMRI) was performed during Go/NoGo task Stop-signal ~ 1 h post-dose. NIH Cognition Toolbox 2 Treatment vs....

10.1038/s41598-020-70037-7 article EN cc-by Scientific Reports 2020-08-04

Tai Chi (TC) controls pain through mind-body exercise and appears to alter inflammatory mediators. TC actions on lipid biomarkers associated with inflammation brain neural networks in women knee osteoarthritic were investigated.A single-center, pre- post-TC group (baseline 8 wk) pilot study postmenopausal was performed. 12 eligible participated exercise. The primary outcome liquid chromatography tandem mass spectrometry determination of circulating endocannabinoids (eCB) oxylipins (OxL)....

10.3389/fmed.2023.1210170 article EN cc-by Frontiers in Medicine 2023-08-16

Luminal breast cancers are the most common genomic subtype of where A have a better prognosis than B. Exposure to sex steroids and inflammatory status due obesity key contributors tumor development. In this study, 1928 patients with cancer 1610 B were compared based on body mass index (BMI), age, race, menopausal status, expressed receptors (i.e., estrogen (ER), progesterone (PR), human epidermal growth factor receptor 2 (HER2)). Patients tumors had significantly higher mean BMI (Δ = 0.69...

10.3390/biomedicines10112931 article EN cc-by Biomedicines 2022-11-15

Obesity is a major risk factor for breast cancer (BC). Obesity-related metabolic alterations such as inflammation and overactivation of the adipose renin–angiotensin system (RAS) may contribute to progression BC. Clinically used antihypertensive drugs angiotensin-converting enzyme inhibitors (ACE-I) dietary bioactive components eicosapentaenoic acid (EPA) are known their anti-inflammatory RAS blocking properties. However, whether EPA enhances protective effects ACE-I in lessening adipocyte...

10.3390/cancers12010220 article EN Cancers 2020-01-16
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