Liesbeth Reneman
A5016425494- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Attention Deficit Hyperactivity Disorder
- Forensic Toxicology and Drug Analysis
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Psychedelics and Drug Studies
- Cannabis and Cannabinoid Research
- Glioma Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Treatment of Major Depression
- Mental Health Research Topics
- Brain Metastases and Treatment
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Schizophrenia research and treatment
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Pituitary Gland Disorders and Treatments
- Health, Environment, Cognitive Aging
- Gastrointestinal motility and disorders
Amsterdam University Medical Centers
2019-2025
University of Amsterdam
2016-2025
Amsterdam Neuroscience
2003-2025
Amsterdam UMC Location University of Amsterdam
2014-2024
Radboud University Medical Center
2016-2024
Radboud University Nijmegen
2016-2024
Emma Kinderziekenhuis
2017-2022
Delft University of Technology
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2019
Sunovion (United States)
2019
Objective: Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonreplications are frequent. The authors sought to identify cortical characteristics related ADHD using large-scale studies. Methods: Cortical thickness surface area (based on the Desikan–Killiany atlas) were compared between case subjects (N=2,246) control (N=1,934) for children, adolescents, separately ENIGMA-ADHD, a...
Chemotherapy is associated with cognitive impairment in a subgroup of breast cancer survivors, but the neural circuitry underlying this side effect largely unknown. Moreover, long-term has not been studied well. In present study, functional magnetic resonance imaging (fMRI) and neuropsychological testing were performed survivors almost 10 years after high-dose adjuvant chemotherapy (chemo group, n = 19) for whom had indicated (control 15). BOLD activation performance measured during an...
Abstract The neural substrate underlying cognitive impairments after chemotherapy is largely unknown. Here, we investigated very late (>9 years) effects of adjuvant high‐dose on brain white and gray matter in primary breast cancer survivors ( n = 17) with multimodal magnetic resonance imaging (MRI). A group who did not receive was scanned for comparison 15). Neuropsychological tests demonstrated the group. Diffusion tensor (DTI) tract‐based spatial statistics showed that associated focal...
Abstract Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in adult MDD patients, whether this process clinical characteristics a large multicenter international dataset. performed mega-analysis by pooling measures derived from T1-weighted MRI scans 19 samples worldwide. Healthy was estimated predicting chronological age (18–75 years) 7 subcortical volumes, 34 cortical thickness...
Response to antidepressant treatment in major depressive disorder varies substantially between individuals, which lengthens the process of finding effective treatment. The authors sought determine whether a multimodal machine learning approach could predict early sertraline response patients with disorder. They assessed predictive contribution MR neuroimaging and clinical assessments at baseline after 1 week
<h3>Background</h3> Although the popular drug 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") has been shown to damage brain serotonin (5-HT) neurons in animals, fate and functional consequences of 5-HT after MDMA injury are not known humans. We investigated long-term effects use on cortical humans memory function, because implicated function. <h3>Methods</h3> Twenty-two recent users, 16 ex-MDMA users who had stopped using for more than 1 year, 13 control subjects. The was studied by...
Abstract Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between and structure using structural MRI ( n = 6420) genetic data 3907) from ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical subcortical abnormalities in both mass-univariate multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found...
An increasing body of literature indicates that chemotherapy (ChT) for breast cancer (BC) is associated with adverse effects on the brain. Recent research suggests cognitive and brain function in patients BC may already be compromised before start chemotherapy. This first study combining neuropsychological testing, patient-reported outcomes, multimodal magnetic resonance imaging (MRI) to examine pretreatment cognition various aspects structure a large sample. Thirty-two scheduled receive ChT...
Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of acquisition quantification. In community-wide effort towards robust reproducible clinical ASL image processing, we developed the software package ExploreASL, allowing standardized analyses across centers scanners. The procedures used in ExploreASL capitalize published processing advancements address challenges multi-center datasets...
Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings been contradictory and based on small samples. Here, we performed the largest ever analysis left-right ADHD, using 39 datasets ENIGMA consortium.
Abstract Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, diagnostic predictive power of existing algorithms has been limited by small sample sizes, lack representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with largest multi-site size date (N = 5365) provide a generalizable ML classification benchmark major depressive disorder (MDD) using shallow...
The selective serotonin reuptake inhibitor (SSRI) Prozac® (fluoxetine) is the only registered antidepressant to treat depression in children and adolescents. Yet, while safety of SSRIs has been well established adults, exerts neurotrophic actions developing brain thereby may have harmful effects Here we treated adolescent adult rats chronically with fluoxetine (12 mg/kg) at postnatal day (PND) 25 46 from PND 67 88, respectively, tested animals 7-14 days after last injection when...
Objectives: The objective of this study was to assess whether HIV-infected patients on long-term successful combination antiretroviral therapy (cART) have more extensive white matter hyperintensities (WMH) presumed vascular origin compared with uninfected controls and these intensities are associated cognitive impairment. Furthermore, we explored potential determinants increased WMH load suppressed HIV infection. Design: A cross-sectional comparison in an observational cohort. Methods:...
Abstract While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date not been wholly consistent. Moreover, most compared brain morphology across those dependent different substances of abuse identify substance‐specific and substance‐general effects. By pooling large multinational datasets from 33 sites, this study examined surface 1628 nondependent controls 2277 individuals alcohol,...