A5009981504- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Reproductive tract infections research
- Antibiotic Use and Resistance
- Global Maternal and Child Health
- Hepatitis Viruses Studies and Epidemiology
- Urinary Tract Infections Management
- HIV/AIDS drug development and treatment
- Cervical Cancer and HPV Research
- Viral gastroenteritis research and epidemiology
- HIV, Drug Use, Sexual Risk
- Healthcare Systems and Practices
- Liver Disease and Transplantation
- Salmonella and Campylobacter epidemiology
- Neonatal and Maternal Infections
- Pharmaceutical and Antibiotic Environmental Impacts
- SARS-CoV-2 and COVID-19 Research
- Child Nutrition and Water Access
- Vaccine Coverage and Hesitancy
- Pneumonia and Respiratory Infections
- Pelvic floor disorders treatments
- COVID-19 and healthcare impacts
- Microbial infections and disease research
Université Paris-Saclay
2017-2024
Centre de recherche en Epidémiologie et Santé des Populations
2020-2024
Université de Versailles Saint-Quentin-en-Yvelines
2015-2024
Inserm
2015-2024
Hôpital Raymond-Poincaré
2018-2024
Assistance Publique – Hôpitaux de Paris
2018-2024
Santé Publique France
1998-2024
Bicêtre Hospital
2021-2023
Institut Pasteur
2011-2021
Université Paris Cité
2018
Summary. Worldwide, the hepatitis B virus (HBV) and C (HCV) cause, respectively, 600 000 350 deaths each year. Viral is leading cause of cirrhosis liver cancer, which in turn ranks as third cancer death worldwide. Within WHO European region, approximately 14 million people are chronically infected with HBV, nine HCV. Lack reliable epidemiological data on HBV HCV one biggest hurdles to advancing policy. Risk groups such migrants injecting drug users (IDU) tend be under‐represented existing...
To monitor the prevalence of hepatitis B and C a cross-sectional survey was conducted in 2004 among French metropolitan residents. A complex sampling design used to enroll 14,416 adult participants aged 18-80 years. Data collected included demographic social characteristics risk factors. Sera were tested for anti-HCV, HCV-RNA, anti-HBc HBsAg. analyzed with SUDAAN software provide weighted estimates resident population. The overall anti-HCV 0.84% (95% CI: 0.65-1.10). Among positive...
Antibiotic misuse in lower- and middle-income countries (LMICs) contributes to the development of antibiotic resistance that can disseminate globally. Strategies specific LMICs seek reduce by humans, but simultaneously improve access, have been proposed. However, most approaches date not considered growing impact animal environmental reservoirs resistance, which threaten exacerbate crisis LMICs. In particular, current strategies do prioritize impacts increased use for terrestrial food-animal...
Antibiotic resistance is a global public health issue, particularly in low- and middle-income countries (LMICs), where antibiotics required to treat resistant infections are not affordable. LMICs also bear disproportionately high burden of bacterial diseases, among children, jeopardizes progress made these areas. Although outpatient antibiotic use major driver resistance, data on inappropriate prescribing scarce at the community level, majority occurs. Here, we aimed characterize young...
Background: Klebsiella pneumoniae (hereafter, Kp) is a major public health threat responsible for high levels of multidrug resistant (MDR) human infections. Besides, Kp also causes severe infections in the community, especially Asia and Africa. Although most are caused by endogenous intestinal carriage, little known about prevalence microbiological characteristics asymptomatic attached risk factors including environmental sources exposure.Methods: Here, 911 pregnant women from communities...
Salmonella enterica is a leading cause of human gastroenteritis. S. strains that produce ESBLs (ESBL-Salm) remain rare in Europe and North America, but less known about their prevalence among animal-derived foods countries with weaker food safety practices unregulated veterinary antibiotic use. To examine the characteristics ESBL-Salm from retail meats Phnom Penh, Cambodia. We tested fish, pork chicken two markets for ESBL- carbapenemase-producing September–December 2016, using cefotaxime-...
To ensure the success of COVID-19 vaccination, public authorities need to have support entire population and build vaccine confidence. Identifying understanding determinants acceptance is essential for conducting strategy. The aim was estimate hesitancy among healthcare students in France investigate associated factors.A web-based cross-sectional study conducted a large French University greater Paris area, 4927 from different training courses such as medicine studies, midwifery...
To document hepatitis C virus (HCV) intrafamilial transmission and assess its relative importance in comparison to other current modes of the country with largest HCV epidemic world. was defined as among relatives living same household.Case-control study. Cases were adult patients acute diagnosed two 'fever hospitals' Cairo. Controls A hospitals, family members cases. All consenting household cases provided blood for serological RNA testing. Homology viral sequences (NS5b region) within...
The spread of extended-spectrum-β-lactamase-producing Enterobacteriaceae (ESBL-PE) in low-income countries, where the burden neonatal sepsis is high, may have a serious impact on mortality rates. Given potential for mother-to-child transmission multiresistant bacteria, this study investigated ESBL-PE rectal colonization among pregnant women at delivery community Madagascar and estimated prevalence 18.5% (95% confidence interval, 14.5% to 22.6%). One strain Klebsiella pneumoniae isolated was...
In low and middle income countries (LMICs), where the burden of neonatal sepsis is highest, spread extended spectrum beta-lactamase-producing enterobacteriaceae (ESBL-PE) in community, potentially contributing to mortality, a public health concern. Data regarding acquisition ESBL-PE during period are scarce. The routes transmission not well defined particularly possible key role played by pregnant women. This study aimed understand community Madagascar. was conducted urban semi-rural areas....
Introduction : La vaccination parmi les professionnels de la santé, y compris ceux en formation, se révèle cruciale pour protection des populations, notamment face aux risques infectieux émergents. Les étudiants santé constituent une population potentiellement exposée virus, avec le potentiel transmettre, tout jouant un rôle majeur tant que futurs prescripteurs. Malgré leur importance, il existe peu d’études sur l’hésitation vaccinale au sein cette population. But l’étude L’objectif revue...
Objective: To identify the routes of transmission during an outbreak infection with hepatitis C virus (HCV) genotype 2a/2c in a hemodialysis unit. Design: A matched case-control study was conducted to risk factors for HCV seroconversion. Direct observation and staff interviews were assess control practices. Molecular methods used comparison infecting isolates from case-patients patients infected before admission Setting: unit treating average 90 patients. Patients: case-patient defined as...
Our objective was to estimate the prevalence of HCV and HBV co-infection among HIV-infected adults in France describe epidemiological characteristics co-infected patients their clinical management. A one-day national cross-sectional survey conducted 2004. random proportional probability sample design used, based on number AIDS cases reported since 1999 by hospital wards. Weighted estimations were computed. (out/in-patients) included after consent. Data collected demographic criteria, HIV,...
To assess the impact of French national hepatitis C prevention programme initiated in 1999, we analysed trends virus (HCV) prevalence, testing and characteristics HCV-infected patient at first referral from 1994 to 2006. We used four data sources: Two population-based sero-prevalence surveys carried out 2004; two surveillance networks, one based on public private laboratories throughout France other hepatology reference centres, which aim monitor, respectively, anti-HCV screening...
Summary In E gypt, as elsewhere, liver biopsy ( LB ) remains the gold standard to assess fibrosis in chronic hepatitis C CHC and is required decide whether a treatment should be proposed. Many of its disadvantages have led develop noninvasive methods replace . These new evaluated where circulating virus genotype 4 G 4), increased body mass index co‐infection with schistosomiasis may interfere assessment. gyptian ‐infected patients underwent , an elastometry measurement F ibroscan © ), serum...
We characterized the composition and structure of vaginal microbiota in a cohort 149 women with genital Chlamydia trachomatis infection at baseline who were followed quarterly for 9 months after antibiotic treatment. At time diagnosis, was dominated by Lactobacillus iners or diverse array bacterial vaginosis-associated bacteria including Gardnerella vaginalis. Interestingly, L. iners-dominated communities most common azithromycin treatment (1 g monodose), consistent observed relative...
To determine risk factors for the occurrence of sporadic Salmonella typhimurium infections among children in France, we conducted a matched case-control study. Cases were identified between 15 June and 30 September 1996. We interviewed 101 pairs case patients control subjects, age place residence. The illness was greater who ate undercooked ground beef than those did not (odds ratio [OR], 5.0; 95% confidence interval [CI], 1.9–13.1). Case more likely subjects to have taken antibiotics during...
Objectives The HEPAIG study was conducted to better understand Hepatitis C virus (HCV) transmission among human immuno-deficiency (HIV)-infected men who have sex with (MSM) and assess incidence of HCV infection this population in France. Methods Results Acute defined by anti-HCV or ribonucleic acid (RNA) positivity within one year documented negativity notified HIV-infected MSM followed up HIV/AIDS clinics from a nationwide sampling frame. HIV characteristics, potential exposures sexual...
Acute hepatitis C continues to be a concern in men who have sex with (MSM), and its optimal management has yet established. In this study, the clinical, biological, therapeutic data of 53 human immunodeficiency virus (HIV)-infected MSM included multicenter prospective study on acute 2006-2007 were retrospectively collected analyzed. The mean (HCV) viral load at diagnosis was 5.8 ± 1.1 log(10) IU/mL (genotype 4, n = 28; genotype 1, 14, 3, 7). cumulative rates spontaneous HCV clearance 11.0%...